Recent advances in brain physiology and cognitive processing

Detalhes bibliográficos
Autor(a) principal: Pereira Junior, Alfredo [UNESP]
Data de Publicação: 2011
Outros Autores: Pereira, Maria Alice Ornellas [UNESP], Furlan, Fábio Augusto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4103/0973-1229.77434
http://hdl.handle.net/11449/72268
Resumo: The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. © MSM 2011.
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spelling Recent advances in brain physiology and cognitive processingAstrocyteCalcium WavesGlutamateInformation ProcessingTripartite SynapseThe discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. © MSM 2011.Department of Philosophy of Science Campus Rubião Jr. State University of São Paulo (UNESP), 18618-000, Botucatu-SPDepartment of Psychiatric Nursing Faculty of Medicine State University of São Paulo (UNESP), Botucatu-SPDepartment of Physiology Faculty of Medicine and Nursing University of Marília, Marília-SPDepartment of Philosophy of Science Campus Rubião Jr. State University of São Paulo (UNESP), 18618-000, Botucatu-SPDepartment of Psychiatric Nursing Faculty of Medicine State University of São Paulo (UNESP), Botucatu-SPUniversidade Estadual Paulista (Unesp)Universidade de Marília (UNIMAR)Pereira Junior, Alfredo [UNESP]Pereira, Maria Alice Ornellas [UNESP]Furlan, Fábio Augusto2014-05-27T11:25:27Z2014-05-27T11:25:27Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article183-192application/pdfhttp://dx.doi.org/10.4103/0973-1229.77434Mens Sana Monographs, v. 9, n. 1, p. 183-192, 2011.0973-12291998-4014http://hdl.handle.net/11449/7226810.4103/0973-1229.774342-s2.0-799551155292-s2.0-79955115529.pdf0000-0002-5960-041XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMens Sana Monographs0,1100,110info:eu-repo/semantics/openAccess2024-08-15T18:47:15Zoai:repositorio.unesp.br:11449/72268Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T18:47:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Recent advances in brain physiology and cognitive processing
title Recent advances in brain physiology and cognitive processing
spellingShingle Recent advances in brain physiology and cognitive processing
Pereira Junior, Alfredo [UNESP]
Astrocyte
Calcium Waves
Glutamate
Information Processing
Tripartite Synapse
title_short Recent advances in brain physiology and cognitive processing
title_full Recent advances in brain physiology and cognitive processing
title_fullStr Recent advances in brain physiology and cognitive processing
title_full_unstemmed Recent advances in brain physiology and cognitive processing
title_sort Recent advances in brain physiology and cognitive processing
author Pereira Junior, Alfredo [UNESP]
author_facet Pereira Junior, Alfredo [UNESP]
Pereira, Maria Alice Ornellas [UNESP]
Furlan, Fábio Augusto
author_role author
author2 Pereira, Maria Alice Ornellas [UNESP]
Furlan, Fábio Augusto
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de Marília (UNIMAR)
dc.contributor.author.fl_str_mv Pereira Junior, Alfredo [UNESP]
Pereira, Maria Alice Ornellas [UNESP]
Furlan, Fábio Augusto
dc.subject.por.fl_str_mv Astrocyte
Calcium Waves
Glutamate
Information Processing
Tripartite Synapse
topic Astrocyte
Calcium Waves
Glutamate
Information Processing
Tripartite Synapse
description The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. © MSM 2011.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2014-05-27T11:25:27Z
2014-05-27T11:25:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4103/0973-1229.77434
Mens Sana Monographs, v. 9, n. 1, p. 183-192, 2011.
0973-1229
1998-4014
http://hdl.handle.net/11449/72268
10.4103/0973-1229.77434
2-s2.0-79955115529
2-s2.0-79955115529.pdf
0000-0002-5960-041X
url http://dx.doi.org/10.4103/0973-1229.77434
http://hdl.handle.net/11449/72268
identifier_str_mv Mens Sana Monographs, v. 9, n. 1, p. 183-192, 2011.
0973-1229
1998-4014
10.4103/0973-1229.77434
2-s2.0-79955115529
2-s2.0-79955115529.pdf
0000-0002-5960-041X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mens Sana Monographs
0,110
0,110
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 183-192
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128178200248320

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