Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity

Detalhes bibliográficos
Autor(a) principal: Gonçalves-Ribeiro, Joana
Data de Publicação: 2019
Outros Autores: Pina, Carolina Campos, Sebastião, Ana M, Vaz, Sandra H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52590
Resumo: Copyright © 2019 Gonçalves-Ribeiro, Pina, Sebastião and Vaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicityNMDARAstrocytesGlutamate transportersSynaptic plasticityTripartite synapseCopyright © 2019 Gonçalves-Ribeiro, Pina, Sebastião and Vaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate uptake; nevertheless, neurons can also express these transporters, albeit in smaller concentrations. When not regulated, glutamate uptake can lead to neuronal death. Indeed, the majority of the studies regarding glutamate transporters have focused on excitotoxicity and the subsequent neuronal loss. However, later studies have found that glutamate uptake is not a static process, evincing a possible correlation between this phenomenon and the efficiency of synaptic transmission and plasticity. In this review, we will focus on the role of the increase in glutamate uptake that occurs during long-term potentiation (LTP) in the hippocampus, as well as on the impairment of long-term depression (LTD) under the same conditions. The mechanism underpinning the modulatory effect of glutamate transporters over synaptic plasticity still remains unascertained; yet, it appears to have a more prominent effect over the N-methyl-D-aspartate receptor (NMDAR), despite changes in other glutamate receptors may also occur.This work was supported by UID/BIM/50005/2019 [project finnanced by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado] and PTDC/BTM-SAL/32147/2017 (FCT). JG-R was in receipt of an FCT fellowship (iMM/BI/96-2018).FrontiersRepositório da Universidade de LisboaGonçalves-Ribeiro, JoanaPina, Carolina CamposSebastião, Ana MVaz, Sandra H.2022-04-28T16:29:23Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52590engFront Cell Neurosci. 2019 Aug 6;13:35710.3389/fncel.2019.003571662-5102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:53Zoai:repositorio.ul.pt:10451/52590Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:40.033458Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
title Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
spellingShingle Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
Gonçalves-Ribeiro, Joana
NMDAR
Astrocytes
Glutamate transporters
Synaptic plasticity
Tripartite synapse
title_short Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
title_full Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
title_fullStr Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
title_full_unstemmed Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
title_sort Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity
author Gonçalves-Ribeiro, Joana
author_facet Gonçalves-Ribeiro, Joana
Pina, Carolina Campos
Sebastião, Ana M
Vaz, Sandra H.
author_role author
author2 Pina, Carolina Campos
Sebastião, Ana M
Vaz, Sandra H.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gonçalves-Ribeiro, Joana
Pina, Carolina Campos
Sebastião, Ana M
Vaz, Sandra H.
dc.subject.por.fl_str_mv NMDAR
Astrocytes
Glutamate transporters
Synaptic plasticity
Tripartite synapse
topic NMDAR
Astrocytes
Glutamate transporters
Synaptic plasticity
Tripartite synapse
description Copyright © 2019 Gonçalves-Ribeiro, Pina, Sebastião and Vaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-04-28T16:29:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52590
url http://hdl.handle.net/10451/52590
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Cell Neurosci. 2019 Aug 6;13:357
10.3389/fncel.2019.00357
1662-5102
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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