Klebsiella-induced infections in domestic species: a case-series study in 697 animals (1997–2019)

• Autor(a) principal: Ribeiro, Márcio Garcia [UNESP]
• Data de Publicação: 2022
• Outros Autores: de Morais, Amanda Bonalume Cordeiro [UNESP], Alves, Ana Carolina [UNESP], Bolaños, Carmen Alicia Daza, de Paula, Carolina Lechinski [UNESP], Portilho, Fábio Vinicius Ramos [UNESP], de Nardi Júnior, Geraldo, Lara, Gustavo Henrique Batista [UNESP], de Souza Araújo Martins, Lorrayne [UNESP], Moraes, Lucieny Sierra [UNESP], Risseti, Rafaela Mastrangelo [UNESP], Guerra, Simony Trevizan [UNESP], Bello, Thaís Spessotto [UNESP], Siqueira, Amanda Keller [UNESP], Bertolini, Amanda Bezerra [UNESP], Rodrigues, Carolina Aparecida [UNESP], Paschoal, Natália Rodrigues [UNESP], de Almeida, Beatriz Oliveira [UNESP], Listoni, Fernando José Paganini [UNESP], Sánchez, Luísa Fernanda García [UNESP], Paes, Antonio Carlos [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1007/s42770-021-00667-0
• Texto Completo: http://dx.doi.org/10.1007/s42770-021-00667-0; http://hdl.handle.net/11449/233995
• topic: Clinical and epidemiological aspects; Companion animals; Klebsiella pneumoniae; Livestock; Multidrug-resistant bacteria

Klebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997–2019). The isolates were obtained from different clinical disorders from dogs (n = 393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n = 22), sheep (n = 5), goats (n = 2), and buffalo (n = 1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 = 12.2%), reproductive (85/697 = 12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 = 16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 = 74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62 = 40.3%), and trimethoprim/sulfamethoxazole (100/252 = 39.7), and multidrug resistance to ≥ 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and ~ 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern.