Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings

Detalhes bibliográficos
Autor(a) principal: Tavares, Flavia
Data de Publicação: 2022
Outros Autores: Cobucci, Gustavo Carvalho, Anjos, Denner Santos dos [UNESP], Fonseca-Alves, Carlos Eduardo, Guimaraes, Thais Ferreira, Campos, Simone Neves de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.22456/1679-9216.116892
http://hdl.handle.net/11449/237735
Resumo: Background: Primary pituitary carcinoma is rarely reported in dogs and only few reports describe its malignancy. In veterinary literature, primary pituitary carcinomas correspond up to 2.4% to 3.4% of intracranial neoplasms found in dogs and information regarding its biological behavior is quite limited. In humans, primary pituitary carcinomas represent less than 1.0% of all tumors found in the pituitary gland. The proposed classification for pituitary carcinoma in humans and dogs determines that the tumor must have its origin in adenohypophyseal region and disseminated metastasis by cerebrospinal fluid or systemically to other organs must be observed. In dogs, a few reports have described primary pituitary carcinoma. The goal of this report was to describe clinical, tomographic, histopathological and immunohistochemistry features of a bitch with primary pituitary carcinoma with adjacent invasion. Case: A 7-year-old female spayed Golden Retriever dog was assessed by general practice due progressive weight loss. muscular atrophy, lethargy, blindness, head pressing, and hyporexia for 21 days. Computed tomography (CT) showed a cerebral parenchyma with expansive extra-axial base formation, originating from sella turcica topography, measuring about 2.0 cm dorsally, displacing the third ventricle, suggesting the diagnosis of pituitary neoplasia. The hormones thyroid-stimulating hormone (TSH) and total thyroxine (T4) as well as stimulation ACTH test were unremarkable. After 7 days, neurological clinical signs progressed and unfortunately the patient died ten days later after hospitalization. A necropsy exam revealed pituitary gland with increased dimensions (2.5 x 2.0 cm). Histopathological findings revealed tumor proliferation in pituitary gland. The neoplasm showed invasion to the nervous parenchyma and metastatic foci between the brain lobes. Immunohistochemistry was positive for keratin and neuron-specific enolase and negative for epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, estrogen receptor, CD34, chromogranin, somatostatin, and ACTH. The clinical, histopathological and immunohistochemistry findings supported the diagnosis of primary pituitary carcinoma. Discussion: There is lack information regarding pituitary carcinoma prevalence in dogs, and little is known about its pathological and clinical features. The patient showed a shorter survival time (30 days after the onset of clinical signs) for a non-hormonally functional tumor that presented with acute onset of neurological signs due to local effect of an expanding mass, also described in others pituitary carcinoma reports. It was observed a metastatic focus of pituitary neoplasia between cerebral hemispheres, leading us to conclude to be a pituitary carcinoma. Adjacent infiltration was noticed by the presence of neoplasm invasion to the synoptic nervous parenchyma and metastatic foci between the brain lobes as well as the presence of a non-delimited nodular area of neoplastic implantation between the cerebral hemispheres, and optic nerve compromised by neoplasm cells. The data reported here showed that a negative ACTH receptor in neoplasm with 10% Ki-67 proliferation index with no history of clinical signs of pituitary-dependent hyperadrenocorticism (PDH). Pituitary adenocarcinomas are thought to be more often non-secretors. CT findings reveled a pituitary mass of 2.5 cm in vertical height suggesting a pituitary macrotumor although there is lack of description for pituitary carcinomas in veterinary literature. The animal had a fast deterioration of his clinical condition and quickly came to death, suggesting poor biological behavior of the tumor.
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spelling Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry FindingsAdrenocorticotropic hormoneCase reportDogPituitary tumorsBackground: Primary pituitary carcinoma is rarely reported in dogs and only few reports describe its malignancy. In veterinary literature, primary pituitary carcinomas correspond up to 2.4% to 3.4% of intracranial neoplasms found in dogs and information regarding its biological behavior is quite limited. In humans, primary pituitary carcinomas represent less than 1.0% of all tumors found in the pituitary gland. The proposed classification for pituitary carcinoma in humans and dogs determines that the tumor must have its origin in adenohypophyseal region and disseminated metastasis by cerebrospinal fluid or systemically to other organs must be observed. In dogs, a few reports have described primary pituitary carcinoma. The goal of this report was to describe clinical, tomographic, histopathological and immunohistochemistry features of a bitch with primary pituitary carcinoma with adjacent invasion. Case: A 7-year-old female spayed Golden Retriever dog was assessed by general practice due progressive weight loss. muscular atrophy, lethargy, blindness, head pressing, and hyporexia for 21 days. Computed tomography (CT) showed a cerebral parenchyma with expansive extra-axial base formation, originating from sella turcica topography, measuring about 2.0 cm dorsally, displacing the third ventricle, suggesting the diagnosis of pituitary neoplasia. The hormones thyroid-stimulating hormone (TSH) and total thyroxine (T4) as well as stimulation ACTH test were unremarkable. After 7 days, neurological clinical signs progressed and unfortunately the patient died ten days later after hospitalization. A necropsy exam revealed pituitary gland with increased dimensions (2.5 x 2.0 cm). Histopathological findings revealed tumor proliferation in pituitary gland. The neoplasm showed invasion to the nervous parenchyma and metastatic foci between the brain lobes. Immunohistochemistry was positive for keratin and neuron-specific enolase and negative for epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, estrogen receptor, CD34, chromogranin, somatostatin, and ACTH. The clinical, histopathological and immunohistochemistry findings supported the diagnosis of primary pituitary carcinoma. Discussion: There is lack information regarding pituitary carcinoma prevalence in dogs, and little is known about its pathological and clinical features. The patient showed a shorter survival time (30 days after the onset of clinical signs) for a non-hormonally functional tumor that presented with acute onset of neurological signs due to local effect of an expanding mass, also described in others pituitary carcinoma reports. It was observed a metastatic focus of pituitary neoplasia between cerebral hemispheres, leading us to conclude to be a pituitary carcinoma. Adjacent infiltration was noticed by the presence of neoplasm invasion to the synoptic nervous parenchyma and metastatic foci between the brain lobes as well as the presence of a non-delimited nodular area of neoplastic implantation between the cerebral hemispheres, and optic nerve compromised by neoplasm cells. The data reported here showed that a negative ACTH receptor in neoplasm with 10% Ki-67 proliferation index with no history of clinical signs of pituitary-dependent hyperadrenocorticism (PDH). Pituitary adenocarcinomas are thought to be more often non-secretors. CT findings reveled a pituitary mass of 2.5 cm in vertical height suggesting a pituitary macrotumor although there is lack of description for pituitary carcinomas in veterinary literature. The animal had a fast deterioration of his clinical condition and quickly came to death, suggesting poor biological behavior of the tumor.Lavras Fed Univ UFLA, Dept Vet Radiol, Lavras, MG, BrazilSao Paulo State Univ, UNESP, Dept Vet Clin & Surg, Jaboticabal, SP, BrazilPaulista Univ UNIP, Inst Hlth Sci, Bauru, SP, BrazilSao Paulo State Univ, UNESP, Dept Vet Clin & Surg, Jaboticabal, SP, BrazilUniv Fed Rio Grande Do SulUniversidade Federal de Lavras (UFLA)Universidade Estadual Paulista (UNESP)Paulista Univ UNIPTavares, FlaviaCobucci, Gustavo CarvalhoAnjos, Denner Santos dos [UNESP]Fonseca-Alves, Carlos EduardoGuimaraes, Thais FerreiraCampos, Simone Neves de2022-11-30T13:43:21Z2022-11-30T13:43:21Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6http://dx.doi.org/10.22456/1679-9216.116892Acta Scientiae Veterinariae. Porto Alegre Rs: Univ Fed Rio Grande Do Sul, v. 50, 6 p., 2022.1678-0345http://hdl.handle.net/11449/23773510.22456/1679-9216.116892WOS:000796549700026Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Scientiae Veterinariaeinfo:eu-repo/semantics/openAccess2024-06-06T14:10:48Zoai:repositorio.unesp.br:11449/237735Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:47:28.656928Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
title Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
spellingShingle Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
Tavares, Flavia
Adrenocorticotropic hormone
Case report
Dog
Pituitary tumors
title_short Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
title_full Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
title_fullStr Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
title_full_unstemmed Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
title_sort Pituitary Carcinoma in a Bitch: Clinical, Tomographic, Histopathological and Immunohistochemistry Findings
author Tavares, Flavia
author_facet Tavares, Flavia
Cobucci, Gustavo Carvalho
Anjos, Denner Santos dos [UNESP]
Fonseca-Alves, Carlos Eduardo
Guimaraes, Thais Ferreira
Campos, Simone Neves de
author_role author
author2 Cobucci, Gustavo Carvalho
Anjos, Denner Santos dos [UNESP]
Fonseca-Alves, Carlos Eduardo
Guimaraes, Thais Ferreira
Campos, Simone Neves de
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Lavras (UFLA)
Universidade Estadual Paulista (UNESP)
Paulista Univ UNIP
dc.contributor.author.fl_str_mv Tavares, Flavia
Cobucci, Gustavo Carvalho
Anjos, Denner Santos dos [UNESP]
Fonseca-Alves, Carlos Eduardo
Guimaraes, Thais Ferreira
Campos, Simone Neves de
dc.subject.por.fl_str_mv Adrenocorticotropic hormone
Case report
Dog
Pituitary tumors
topic Adrenocorticotropic hormone
Case report
Dog
Pituitary tumors
description Background: Primary pituitary carcinoma is rarely reported in dogs and only few reports describe its malignancy. In veterinary literature, primary pituitary carcinomas correspond up to 2.4% to 3.4% of intracranial neoplasms found in dogs and information regarding its biological behavior is quite limited. In humans, primary pituitary carcinomas represent less than 1.0% of all tumors found in the pituitary gland. The proposed classification for pituitary carcinoma in humans and dogs determines that the tumor must have its origin in adenohypophyseal region and disseminated metastasis by cerebrospinal fluid or systemically to other organs must be observed. In dogs, a few reports have described primary pituitary carcinoma. The goal of this report was to describe clinical, tomographic, histopathological and immunohistochemistry features of a bitch with primary pituitary carcinoma with adjacent invasion. Case: A 7-year-old female spayed Golden Retriever dog was assessed by general practice due progressive weight loss. muscular atrophy, lethargy, blindness, head pressing, and hyporexia for 21 days. Computed tomography (CT) showed a cerebral parenchyma with expansive extra-axial base formation, originating from sella turcica topography, measuring about 2.0 cm dorsally, displacing the third ventricle, suggesting the diagnosis of pituitary neoplasia. The hormones thyroid-stimulating hormone (TSH) and total thyroxine (T4) as well as stimulation ACTH test were unremarkable. After 7 days, neurological clinical signs progressed and unfortunately the patient died ten days later after hospitalization. A necropsy exam revealed pituitary gland with increased dimensions (2.5 x 2.0 cm). Histopathological findings revealed tumor proliferation in pituitary gland. The neoplasm showed invasion to the nervous parenchyma and metastatic foci between the brain lobes. Immunohistochemistry was positive for keratin and neuron-specific enolase and negative for epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, estrogen receptor, CD34, chromogranin, somatostatin, and ACTH. The clinical, histopathological and immunohistochemistry findings supported the diagnosis of primary pituitary carcinoma. Discussion: There is lack information regarding pituitary carcinoma prevalence in dogs, and little is known about its pathological and clinical features. The patient showed a shorter survival time (30 days after the onset of clinical signs) for a non-hormonally functional tumor that presented with acute onset of neurological signs due to local effect of an expanding mass, also described in others pituitary carcinoma reports. It was observed a metastatic focus of pituitary neoplasia between cerebral hemispheres, leading us to conclude to be a pituitary carcinoma. Adjacent infiltration was noticed by the presence of neoplasm invasion to the synoptic nervous parenchyma and metastatic foci between the brain lobes as well as the presence of a non-delimited nodular area of neoplastic implantation between the cerebral hemispheres, and optic nerve compromised by neoplasm cells. The data reported here showed that a negative ACTH receptor in neoplasm with 10% Ki-67 proliferation index with no history of clinical signs of pituitary-dependent hyperadrenocorticism (PDH). Pituitary adenocarcinomas are thought to be more often non-secretors. CT findings reveled a pituitary mass of 2.5 cm in vertical height suggesting a pituitary macrotumor although there is lack of description for pituitary carcinomas in veterinary literature. The animal had a fast deterioration of his clinical condition and quickly came to death, suggesting poor biological behavior of the tumor.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-30T13:43:21Z
2022-11-30T13:43:21Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.22456/1679-9216.116892
Acta Scientiae Veterinariae. Porto Alegre Rs: Univ Fed Rio Grande Do Sul, v. 50, 6 p., 2022.
1678-0345
http://hdl.handle.net/11449/237735
10.22456/1679-9216.116892
WOS:000796549700026
url http://dx.doi.org/10.22456/1679-9216.116892
http://hdl.handle.net/11449/237735
identifier_str_mv Acta Scientiae Veterinariae. Porto Alegre Rs: Univ Fed Rio Grande Do Sul, v. 50, 6 p., 2022.
1678-0345
10.22456/1679-9216.116892
WOS:000796549700026
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Univ Fed Rio Grande Do Sul
publisher.none.fl_str_mv Univ Fed Rio Grande Do Sul
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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