Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes

Detalhes bibliográficos
Autor(a) principal: Vieira, Evanice Menezes Marçal [UNESP]
Data de Publicação: 2008
Outros Autores: Ueno, Camila Satie Ferreira [UNESP], Valva, Vivian Neves [UNESP], Goulart, Maria das Graças Vilela [UNESP], Nogueira, Terezinha de Oliveira [UNESP], Gomes, Mônica Fernandes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1806-83242008000200015
http://hdl.handle.net/11449/70520
Resumo: This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.
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spelling Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetesAlloxanBone regenerationDiabetes complicationsDiabetes mellitusalloxanbiomaterialpolitefanalysis of varianceanimalbone regenerationchemically induced disorderdisease modeldrug effectexperimental diabetes mellituspancreaspathophysiologyphysiologyrabbitrandomizationskullwound healingAnalysis of VarianceAnimalsBiocompatible MaterialsBone RegenerationDiabetes Mellitus, ExperimentalDisease Models, AnimalPancreasParietal BonePolytetrafluoroethyleneRabbitsRandom AllocationSkullWound HealingThis research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.Oral Biopathology Program School of Dentistry of São Jose dos Campos São Paulo State University (UNESP), São PauloSpecial Health Care Needs Association (ASPE) Bioscience Center for Special Health Care Needs (CEBAPE/UNESP) São Paulo State University (UNESP), São Paulo, SP, Av. Eng. Francisco José Lango, 777, São José dos Campos, SP 12245-000Oral Biopathology Program School of Dentistry of São Jose dos Campos São Paulo State University (UNESP), São PauloSpecial Health Care Needs Association (ASPE) Bioscience Center for Special Health Care Needs (CEBAPE/UNESP) São Paulo State University (UNESP), São Paulo, SPUniversidade Estadual Paulista (Unesp)Vieira, Evanice Menezes Marçal [UNESP]Ueno, Camila Satie Ferreira [UNESP]Valva, Vivian Neves [UNESP]Goulart, Maria das Graças Vilela [UNESP]Nogueira, Terezinha de Oliveira [UNESP]Gomes, Mônica Fernandes [UNESP]2014-05-27T11:23:38Z2014-05-27T11:23:38Z2008-08-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article184-191application/pdfhttp://dx.doi.org/10.1590/S1806-83242008000200015Brazilian Oral Research, v. 22, n. 2, p. 184-191, 2008.1806-83241807-3107http://hdl.handle.net/11449/7052010.1590/S1806-83242008000200015S1806-832420080002000152-s2.0-482491381492-s2.0-48249138149.pdf1274225455678400Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Research1.223info:eu-repo/semantics/openAccess2024-01-25T06:34:42Zoai:repositorio.unesp.br:11449/70520Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:58:09.186031Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
title Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
spellingShingle Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
Vieira, Evanice Menezes Marçal [UNESP]
Alloxan
Bone regeneration
Diabetes complications
Diabetes mellitus
alloxan
biomaterial
politef
analysis of variance
animal
bone regeneration
chemically induced disorder
disease model
drug effect
experimental diabetes mellitus
pancreas
pathophysiology
physiology
rabbit
randomization
skull
wound healing
Analysis of Variance
Animals
Biocompatible Materials
Bone Regeneration
Diabetes Mellitus, Experimental
Disease Models, Animal
Pancreas
Parietal Bone
Polytetrafluoroethylene
Rabbits
Random Allocation
Skull
Wound Healing
title_short Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
title_full Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
title_fullStr Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
title_full_unstemmed Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
title_sort Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
author Vieira, Evanice Menezes Marçal [UNESP]
author_facet Vieira, Evanice Menezes Marçal [UNESP]
Ueno, Camila Satie Ferreira [UNESP]
Valva, Vivian Neves [UNESP]
Goulart, Maria das Graças Vilela [UNESP]
Nogueira, Terezinha de Oliveira [UNESP]
Gomes, Mônica Fernandes [UNESP]
author_role author
author2 Ueno, Camila Satie Ferreira [UNESP]
Valva, Vivian Neves [UNESP]
Goulart, Maria das Graças Vilela [UNESP]
Nogueira, Terezinha de Oliveira [UNESP]
Gomes, Mônica Fernandes [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Vieira, Evanice Menezes Marçal [UNESP]
Ueno, Camila Satie Ferreira [UNESP]
Valva, Vivian Neves [UNESP]
Goulart, Maria das Graças Vilela [UNESP]
Nogueira, Terezinha de Oliveira [UNESP]
Gomes, Mônica Fernandes [UNESP]
dc.subject.por.fl_str_mv Alloxan
Bone regeneration
Diabetes complications
Diabetes mellitus
alloxan
biomaterial
politef
analysis of variance
animal
bone regeneration
chemically induced disorder
disease model
drug effect
experimental diabetes mellitus
pancreas
pathophysiology
physiology
rabbit
randomization
skull
wound healing
Analysis of Variance
Animals
Biocompatible Materials
Bone Regeneration
Diabetes Mellitus, Experimental
Disease Models, Animal
Pancreas
Parietal Bone
Polytetrafluoroethylene
Rabbits
Random Allocation
Skull
Wound Healing
topic Alloxan
Bone regeneration
Diabetes complications
Diabetes mellitus
alloxan
biomaterial
politef
analysis of variance
animal
bone regeneration
chemically induced disorder
disease model
drug effect
experimental diabetes mellitus
pancreas
pathophysiology
physiology
rabbit
randomization
skull
wound healing
Analysis of Variance
Animals
Biocompatible Materials
Bone Regeneration
Diabetes Mellitus, Experimental
Disease Models, Animal
Pancreas
Parietal Bone
Polytetrafluoroethylene
Rabbits
Random Allocation
Skull
Wound Healing
description This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.
publishDate 2008
dc.date.none.fl_str_mv 2008-08-04
2014-05-27T11:23:38Z
2014-05-27T11:23:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1806-83242008000200015
Brazilian Oral Research, v. 22, n. 2, p. 184-191, 2008.
1806-8324
1807-3107
http://hdl.handle.net/11449/70520
10.1590/S1806-83242008000200015
S1806-83242008000200015
2-s2.0-48249138149
2-s2.0-48249138149.pdf
1274225455678400
url http://dx.doi.org/10.1590/S1806-83242008000200015
http://hdl.handle.net/11449/70520
identifier_str_mv Brazilian Oral Research, v. 22, n. 2, p. 184-191, 2008.
1806-8324
1807-3107
10.1590/S1806-83242008000200015
S1806-83242008000200015
2-s2.0-48249138149
2-s2.0-48249138149.pdf
1274225455678400
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Oral Research
1.223
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 184-191
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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