Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1806-83242008000200015 http://hdl.handle.net/11449/70520 |
Resumo: | This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis. |
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Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetesAlloxanBone regenerationDiabetes complicationsDiabetes mellitusalloxanbiomaterialpolitefanalysis of varianceanimalbone regenerationchemically induced disorderdisease modeldrug effectexperimental diabetes mellituspancreaspathophysiologyphysiologyrabbitrandomizationskullwound healingAnalysis of VarianceAnimalsBiocompatible MaterialsBone RegenerationDiabetes Mellitus, ExperimentalDisease Models, AnimalPancreasParietal BonePolytetrafluoroethyleneRabbitsRandom AllocationSkullWound HealingThis research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.Oral Biopathology Program School of Dentistry of São Jose dos Campos São Paulo State University (UNESP), São PauloSpecial Health Care Needs Association (ASPE) Bioscience Center for Special Health Care Needs (CEBAPE/UNESP) São Paulo State University (UNESP), São Paulo, SP, Av. Eng. Francisco José Lango, 777, São José dos Campos, SP 12245-000Oral Biopathology Program School of Dentistry of São Jose dos Campos São Paulo State University (UNESP), São PauloSpecial Health Care Needs Association (ASPE) Bioscience Center for Special Health Care Needs (CEBAPE/UNESP) São Paulo State University (UNESP), São Paulo, SPUniversidade Estadual Paulista (Unesp)Vieira, Evanice Menezes Marçal [UNESP]Ueno, Camila Satie Ferreira [UNESP]Valva, Vivian Neves [UNESP]Goulart, Maria das Graças Vilela [UNESP]Nogueira, Terezinha de Oliveira [UNESP]Gomes, Mônica Fernandes [UNESP]2014-05-27T11:23:38Z2014-05-27T11:23:38Z2008-08-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article184-191application/pdfhttp://dx.doi.org/10.1590/S1806-83242008000200015Brazilian Oral Research, v. 22, n. 2, p. 184-191, 2008.1806-83241807-3107http://hdl.handle.net/11449/7052010.1590/S1806-83242008000200015S1806-832420080002000152-s2.0-482491381492-s2.0-48249138149.pdf1274225455678400Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Research1.223info:eu-repo/semantics/openAccess2024-01-25T06:34:42Zoai:repositorio.unesp.br:11449/70520Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:58:09.186031Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
title |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
spellingShingle |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes Vieira, Evanice Menezes Marçal [UNESP] Alloxan Bone regeneration Diabetes complications Diabetes mellitus alloxan biomaterial politef analysis of variance animal bone regeneration chemically induced disorder disease model drug effect experimental diabetes mellitus pancreas pathophysiology physiology rabbit randomization skull wound healing Analysis of Variance Animals Biocompatible Materials Bone Regeneration Diabetes Mellitus, Experimental Disease Models, Animal Pancreas Parietal Bone Polytetrafluoroethylene Rabbits Random Allocation Skull Wound Healing |
title_short |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
title_full |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
title_fullStr |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
title_full_unstemmed |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
title_sort |
Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes |
author |
Vieira, Evanice Menezes Marçal [UNESP] |
author_facet |
Vieira, Evanice Menezes Marçal [UNESP] Ueno, Camila Satie Ferreira [UNESP] Valva, Vivian Neves [UNESP] Goulart, Maria das Graças Vilela [UNESP] Nogueira, Terezinha de Oliveira [UNESP] Gomes, Mônica Fernandes [UNESP] |
author_role |
author |
author2 |
Ueno, Camila Satie Ferreira [UNESP] Valva, Vivian Neves [UNESP] Goulart, Maria das Graças Vilela [UNESP] Nogueira, Terezinha de Oliveira [UNESP] Gomes, Mônica Fernandes [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Vieira, Evanice Menezes Marçal [UNESP] Ueno, Camila Satie Ferreira [UNESP] Valva, Vivian Neves [UNESP] Goulart, Maria das Graças Vilela [UNESP] Nogueira, Terezinha de Oliveira [UNESP] Gomes, Mônica Fernandes [UNESP] |
dc.subject.por.fl_str_mv |
Alloxan Bone regeneration Diabetes complications Diabetes mellitus alloxan biomaterial politef analysis of variance animal bone regeneration chemically induced disorder disease model drug effect experimental diabetes mellitus pancreas pathophysiology physiology rabbit randomization skull wound healing Analysis of Variance Animals Biocompatible Materials Bone Regeneration Diabetes Mellitus, Experimental Disease Models, Animal Pancreas Parietal Bone Polytetrafluoroethylene Rabbits Random Allocation Skull Wound Healing |
topic |
Alloxan Bone regeneration Diabetes complications Diabetes mellitus alloxan biomaterial politef analysis of variance animal bone regeneration chemically induced disorder disease model drug effect experimental diabetes mellitus pancreas pathophysiology physiology rabbit randomization skull wound healing Analysis of Variance Animals Biocompatible Materials Bone Regeneration Diabetes Mellitus, Experimental Disease Models, Animal Pancreas Parietal Bone Polytetrafluoroethylene Rabbits Random Allocation Skull Wound Healing |
description |
This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-04 2014-05-27T11:23:38Z 2014-05-27T11:23:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1806-83242008000200015 Brazilian Oral Research, v. 22, n. 2, p. 184-191, 2008. 1806-8324 1807-3107 http://hdl.handle.net/11449/70520 10.1590/S1806-83242008000200015 S1806-83242008000200015 2-s2.0-48249138149 2-s2.0-48249138149.pdf 1274225455678400 |
url |
http://dx.doi.org/10.1590/S1806-83242008000200015 http://hdl.handle.net/11449/70520 |
identifier_str_mv |
Brazilian Oral Research, v. 22, n. 2, p. 184-191, 2008. 1806-8324 1807-3107 10.1590/S1806-83242008000200015 S1806-83242008000200015 2-s2.0-48249138149 2-s2.0-48249138149.pdf 1274225455678400 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Oral Research 1.223 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
184-191 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129567946178560 |