New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.carbpol.2021.118436 http://hdl.handle.net/11449/233269 |
Resumo: | Polyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs. |
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New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfateChitosanChitosan oligosaccharideDextran sulfateMolecular weightNanoparticlesPolyelectrolyte complexationPolyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual PaulistaFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)Nanomedicine and Nanotoxicology Group (GNANO) University of São Paulo (USP)Department of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2019/10761-5Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Carvalho, Suzana Gonçalves [UNESP]dos Santos, Aline Martins [UNESP]Silvestre, Amanda Letícia Polli [UNESP]Meneguin, Andréia Bagliotti [UNESP]Ferreira, Leonardo Miziara BarbozaChorilli, Marlus [UNESP]Gremião, Maria Palmira Daflon [UNESP]2022-05-01T06:02:34Z2022-05-01T06:02:34Z2021-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.carbpol.2021.118436Carbohydrate Polymers, v. 271.0144-8617http://hdl.handle.net/11449/23326910.1016/j.carbpol.2021.1184362-s2.0-85110276829Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymersinfo:eu-repo/semantics/openAccess2024-06-24T13:44:51Zoai:repositorio.unesp.br:11449/233269Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:45:49.888500Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
title |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
spellingShingle |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate Carvalho, Suzana Gonçalves [UNESP] Chitosan Chitosan oligosaccharide Dextran sulfate Molecular weight Nanoparticles Polyelectrolyte complexation |
title_short |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
title_full |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
title_fullStr |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
title_full_unstemmed |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
title_sort |
New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate |
author |
Carvalho, Suzana Gonçalves [UNESP] |
author_facet |
Carvalho, Suzana Gonçalves [UNESP] dos Santos, Aline Martins [UNESP] Silvestre, Amanda Letícia Polli [UNESP] Meneguin, Andréia Bagliotti [UNESP] Ferreira, Leonardo Miziara Barboza Chorilli, Marlus [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author_role |
author |
author2 |
dos Santos, Aline Martins [UNESP] Silvestre, Amanda Letícia Polli [UNESP] Meneguin, Andréia Bagliotti [UNESP] Ferreira, Leonardo Miziara Barboza Chorilli, Marlus [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Carvalho, Suzana Gonçalves [UNESP] dos Santos, Aline Martins [UNESP] Silvestre, Amanda Letícia Polli [UNESP] Meneguin, Andréia Bagliotti [UNESP] Ferreira, Leonardo Miziara Barboza Chorilli, Marlus [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
dc.subject.por.fl_str_mv |
Chitosan Chitosan oligosaccharide Dextran sulfate Molecular weight Nanoparticles Polyelectrolyte complexation |
topic |
Chitosan Chitosan oligosaccharide Dextran sulfate Molecular weight Nanoparticles Polyelectrolyte complexation |
description |
Polyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-01 2022-05-01T06:02:34Z 2022-05-01T06:02:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.carbpol.2021.118436 Carbohydrate Polymers, v. 271. 0144-8617 http://hdl.handle.net/11449/233269 10.1016/j.carbpol.2021.118436 2-s2.0-85110276829 |
url |
http://dx.doi.org/10.1016/j.carbpol.2021.118436 http://hdl.handle.net/11449/233269 |
identifier_str_mv |
Carbohydrate Polymers, v. 271. 0144-8617 10.1016/j.carbpol.2021.118436 2-s2.0-85110276829 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carbohydrate Polymers |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128273184456704 |