New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate

Detalhes bibliográficos
Autor(a) principal: Carvalho, Suzana Gonçalves [UNESP]
Data de Publicação: 2021
Outros Autores: dos Santos, Aline Martins [UNESP], Silvestre, Amanda Letícia Polli [UNESP], Meneguin, Andréia Bagliotti [UNESP], Ferreira, Leonardo Miziara Barboza, Chorilli, Marlus [UNESP], Gremião, Maria Palmira Daflon [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.carbpol.2021.118436
http://hdl.handle.net/11449/233269
Resumo: Polyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs.
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spelling New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfateChitosanChitosan oligosaccharideDextran sulfateMolecular weightNanoparticlesPolyelectrolyte complexationPolyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual PaulistaFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)Nanomedicine and Nanotoxicology Group (GNANO) University of São Paulo (USP)Department of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2019/10761-5Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Carvalho, Suzana Gonçalves [UNESP]dos Santos, Aline Martins [UNESP]Silvestre, Amanda Letícia Polli [UNESP]Meneguin, Andréia Bagliotti [UNESP]Ferreira, Leonardo Miziara BarbozaChorilli, Marlus [UNESP]Gremião, Maria Palmira Daflon [UNESP]2022-05-01T06:02:34Z2022-05-01T06:02:34Z2021-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.carbpol.2021.118436Carbohydrate Polymers, v. 271.0144-8617http://hdl.handle.net/11449/23326910.1016/j.carbpol.2021.1184362-s2.0-85110276829Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymersinfo:eu-repo/semantics/openAccess2024-06-24T13:44:51Zoai:repositorio.unesp.br:11449/233269Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:45:49.888500Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
title New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
spellingShingle New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
Carvalho, Suzana Gonçalves [UNESP]
Chitosan
Chitosan oligosaccharide
Dextran sulfate
Molecular weight
Nanoparticles
Polyelectrolyte complexation
title_short New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
title_full New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
title_fullStr New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
title_full_unstemmed New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
title_sort New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate
author Carvalho, Suzana Gonçalves [UNESP]
author_facet Carvalho, Suzana Gonçalves [UNESP]
dos Santos, Aline Martins [UNESP]
Silvestre, Amanda Letícia Polli [UNESP]
Meneguin, Andréia Bagliotti [UNESP]
Ferreira, Leonardo Miziara Barboza
Chorilli, Marlus [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
author_role author
author2 dos Santos, Aline Martins [UNESP]
Silvestre, Amanda Letícia Polli [UNESP]
Meneguin, Andréia Bagliotti [UNESP]
Ferreira, Leonardo Miziara Barboza
Chorilli, Marlus [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Carvalho, Suzana Gonçalves [UNESP]
dos Santos, Aline Martins [UNESP]
Silvestre, Amanda Letícia Polli [UNESP]
Meneguin, Andréia Bagliotti [UNESP]
Ferreira, Leonardo Miziara Barboza
Chorilli, Marlus [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
dc.subject.por.fl_str_mv Chitosan
Chitosan oligosaccharide
Dextran sulfate
Molecular weight
Nanoparticles
Polyelectrolyte complexation
topic Chitosan
Chitosan oligosaccharide
Dextran sulfate
Molecular weight
Nanoparticles
Polyelectrolyte complexation
description Polyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-01
2022-05-01T06:02:34Z
2022-05-01T06:02:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.carbpol.2021.118436
Carbohydrate Polymers, v. 271.
0144-8617
http://hdl.handle.net/11449/233269
10.1016/j.carbpol.2021.118436
2-s2.0-85110276829
url http://dx.doi.org/10.1016/j.carbpol.2021.118436
http://hdl.handle.net/11449/233269
identifier_str_mv Carbohydrate Polymers, v. 271.
0144-8617
10.1016/j.carbpol.2021.118436
2-s2.0-85110276829
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carbohydrate Polymers
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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