Estudo da influência das variáveis no recobrimento de nanopartículas magnéticas de ferrita com quitosana

• Autor(a) principal: Mello, Patricia Oliveira [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/145423; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2016-09-20/000869918.pdf
• topic: Nanopartículas; Ferrita (Materiais magneticos); Quitosana; Câncer - Tratamento

Cancer is the result of a series of genetic changes that occur randomly, with no genetically identical cases. A variety of types of cancer stems from the different cell types, combined with vast possibility of mutations that trigger other diseases, making a cure for cancer a major challenge. These facts lead to the adoption of a wide diversity in the therapeutic measures and / or clinical procedures for its diagnosis and treatment. The use of magnetic nanoparticles is an interesting alternative to diagnose such diseases. These structures serve as contrast agents for Magnetic Resonance Imaging (MRI) or alternate current biosusceptometry (BAC). It is also possible to use them as agents of therapy, carting anticancer drugs and / or generating heat (hyperthermia). Since it is formed by magnetic material, the nanoparticles can be manipulated by an external magnetic field gradient, leading to many applications involving the transportation and / or target specific cell immobilization. In short, the magnetic nanoparticles can be used as markers for diagnosis and carrier agents for hyperthermia cancer therapy. In this work the surface of magnetic material, ferrite of manganese and zinc, was coated with chitosan by the method of reverse micelle in order to promote the selective incorporation of nanocomposites by cancer cells. Variations in parameters of the synthesis process of these nanocomposites were performed, namely, the ratio of ferrite / chitosan, Oil Volume, Total Water Volume and Percent of Acetic Acid, and these samples were compared to a standard, to analyze possible way to optimize these structures. The condition that presented the best results was that named standard. The primary cell tests with cancer cells proved the absorption of nanoparticles by cells...