High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.14814/phy2.15635 http://hdl.handle.net/11449/245257 |
Resumo: | The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation. |
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High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesitydietsinflammationobesityoxidative stressratsThe study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation.Fundacao de Amparo a Pesquisa e Inovacao do Espirito SantoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Espirito Santo, Hlth Sci Ctr, Postgrad Program Nutr & Hlth, Vitoria, ES, BrazilUniv Fed Espirito Santo, Hlth Sci Ctr, Postgrad Program Physiol Sci, Vitoria, ES, BrazilUniv Fed Espirito Santo, Ctr Phys Educ & Sports, Postgrad Program Phys Educ, Vitoria, ES, BrazilSao Paulo State Univ, Med Sch, Botucatu, SP, BrazilUniv Vila Velha, Vila Velha, ES, BrazilUniv Fed Espirito Santo, Hlth Sci Ctr, Dept Morphol, Vitoria, ES, BrazilUniv Fed Espirito Santo, Ctr Phys Educ & Sports, Vitoria, ES, BrazilUniv Fed Espirito Santo, Ctr Phys Educ & Sports, BR-29075910 Vitoria, ES, BrazilSao Paulo State Univ, Med Sch, Botucatu, SP, BrazilFundacao de Amparo a Pesquisa e Inovacao do Espirito Santo: 545/2018CNPq: 402090/2016-0Wiley-BlackwellUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (UNESP)Univ Vila VelhaKobi, Jessika Butcovsky Botto SarterMatias, Amanda MartinsGasparini, Patricia Vasconcelos FontanaTorezani-Sales, SuellemMadureira, Amanda RangelSilva, Daniel Sesana daCorrea, Camila Renata [UNESP]Garcia, Jessica Leite [UNESP]Haese, DouglasNogueira, Breno ValentimAssis, Aricia Leone Evangelista Monteiro deLima-Leopoldo, Ana PaulaLeopoldo, Andre Soares2023-07-29T11:49:47Z2023-07-29T11:49:47Z2023-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13http://dx.doi.org/10.14814/phy2.15635Physiological Reports. Hoboken: Wiley, v. 11, n. 7, 13 p., 2023.2051-817Xhttp://hdl.handle.net/11449/24525710.14814/phy2.15635WOS:000968950400001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiological Reportsinfo:eu-repo/semantics/openAccess2023-07-29T11:49:47Zoai:repositorio.unesp.br:11449/245257Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:09:21.501830Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
title |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
spellingShingle |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity Kobi, Jessika Butcovsky Botto Sarter diets inflammation obesity oxidative stress rats |
title_short |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
title_full |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
title_fullStr |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
title_full_unstemmed |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
title_sort |
High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity |
author |
Kobi, Jessika Butcovsky Botto Sarter |
author_facet |
Kobi, Jessika Butcovsky Botto Sarter Matias, Amanda Martins Gasparini, Patricia Vasconcelos Fontana Torezani-Sales, Suellem Madureira, Amanda Rangel Silva, Daniel Sesana da Correa, Camila Renata [UNESP] Garcia, Jessica Leite [UNESP] Haese, Douglas Nogueira, Breno Valentim Assis, Aricia Leone Evangelista Monteiro de Lima-Leopoldo, Ana Paula Leopoldo, Andre Soares |
author_role |
author |
author2 |
Matias, Amanda Martins Gasparini, Patricia Vasconcelos Fontana Torezani-Sales, Suellem Madureira, Amanda Rangel Silva, Daniel Sesana da Correa, Camila Renata [UNESP] Garcia, Jessica Leite [UNESP] Haese, Douglas Nogueira, Breno Valentim Assis, Aricia Leone Evangelista Monteiro de Lima-Leopoldo, Ana Paula Leopoldo, Andre Soares |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Espírito Santo (UFES) Universidade Estadual Paulista (UNESP) Univ Vila Velha |
dc.contributor.author.fl_str_mv |
Kobi, Jessika Butcovsky Botto Sarter Matias, Amanda Martins Gasparini, Patricia Vasconcelos Fontana Torezani-Sales, Suellem Madureira, Amanda Rangel Silva, Daniel Sesana da Correa, Camila Renata [UNESP] Garcia, Jessica Leite [UNESP] Haese, Douglas Nogueira, Breno Valentim Assis, Aricia Leone Evangelista Monteiro de Lima-Leopoldo, Ana Paula Leopoldo, Andre Soares |
dc.subject.por.fl_str_mv |
diets inflammation obesity oxidative stress rats |
topic |
diets inflammation obesity oxidative stress rats |
description |
The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T11:49:47Z 2023-07-29T11:49:47Z 2023-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.14814/phy2.15635 Physiological Reports. Hoboken: Wiley, v. 11, n. 7, 13 p., 2023. 2051-817X http://hdl.handle.net/11449/245257 10.14814/phy2.15635 WOS:000968950400001 |
url |
http://dx.doi.org/10.14814/phy2.15635 http://hdl.handle.net/11449/245257 |
identifier_str_mv |
Physiological Reports. Hoboken: Wiley, v. 11, n. 7, 13 p., 2023. 2051-817X 10.14814/phy2.15635 WOS:000968950400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiological Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129026046296064 |