High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

Detalhes bibliográficos
Autor(a) principal: Kobi, Jessika Butcovsky Botto Sarter
Data de Publicação: 2023
Outros Autores: Matias, Amanda Martins, Gasparini, Patricia Vasconcelos Fontana, Torezani-Sales, Suellem, Madureira, Amanda Rangel, Silva, Daniel Sesana da, Correa, Camila Renata [UNESP], Garcia, Jessica Leite [UNESP], Haese, Douglas, Nogueira, Breno Valentim, Assis, Aricia Leone Evangelista Monteiro de, Lima-Leopoldo, Ana Paula, Leopoldo, Andre Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.14814/phy2.15635
http://hdl.handle.net/11449/245257
Resumo: The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation.
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spelling High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesitydietsinflammationobesityoxidative stressratsThe study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation.Fundacao de Amparo a Pesquisa e Inovacao do Espirito SantoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Espirito Santo, Hlth Sci Ctr, Postgrad Program Nutr & Hlth, Vitoria, ES, BrazilUniv Fed Espirito Santo, Hlth Sci Ctr, Postgrad Program Physiol Sci, Vitoria, ES, BrazilUniv Fed Espirito Santo, Ctr Phys Educ & Sports, Postgrad Program Phys Educ, Vitoria, ES, BrazilSao Paulo State Univ, Med Sch, Botucatu, SP, BrazilUniv Vila Velha, Vila Velha, ES, BrazilUniv Fed Espirito Santo, Hlth Sci Ctr, Dept Morphol, Vitoria, ES, BrazilUniv Fed Espirito Santo, Ctr Phys Educ & Sports, Vitoria, ES, BrazilUniv Fed Espirito Santo, Ctr Phys Educ & Sports, BR-29075910 Vitoria, ES, BrazilSao Paulo State Univ, Med Sch, Botucatu, SP, BrazilFundacao de Amparo a Pesquisa e Inovacao do Espirito Santo: 545/2018CNPq: 402090/2016-0Wiley-BlackwellUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (UNESP)Univ Vila VelhaKobi, Jessika Butcovsky Botto SarterMatias, Amanda MartinsGasparini, Patricia Vasconcelos FontanaTorezani-Sales, SuellemMadureira, Amanda RangelSilva, Daniel Sesana daCorrea, Camila Renata [UNESP]Garcia, Jessica Leite [UNESP]Haese, DouglasNogueira, Breno ValentimAssis, Aricia Leone Evangelista Monteiro deLima-Leopoldo, Ana PaulaLeopoldo, Andre Soares2023-07-29T11:49:47Z2023-07-29T11:49:47Z2023-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13http://dx.doi.org/10.14814/phy2.15635Physiological Reports. Hoboken: Wiley, v. 11, n. 7, 13 p., 2023.2051-817Xhttp://hdl.handle.net/11449/24525710.14814/phy2.15635WOS:000968950400001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiological Reportsinfo:eu-repo/semantics/openAccess2023-07-29T11:49:47Zoai:repositorio.unesp.br:11449/245257Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:09:21.501830Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
title High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
spellingShingle High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
Kobi, Jessika Butcovsky Botto Sarter
diets
inflammation
obesity
oxidative stress
rats
title_short High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
title_full High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
title_fullStr High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
title_full_unstemmed High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
title_sort High-fat, high-sucrose, and combined high-fat/high-sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
author Kobi, Jessika Butcovsky Botto Sarter
author_facet Kobi, Jessika Butcovsky Botto Sarter
Matias, Amanda Martins
Gasparini, Patricia Vasconcelos Fontana
Torezani-Sales, Suellem
Madureira, Amanda Rangel
Silva, Daniel Sesana da
Correa, Camila Renata [UNESP]
Garcia, Jessica Leite [UNESP]
Haese, Douglas
Nogueira, Breno Valentim
Assis, Aricia Leone Evangelista Monteiro de
Lima-Leopoldo, Ana Paula
Leopoldo, Andre Soares
author_role author
author2 Matias, Amanda Martins
Gasparini, Patricia Vasconcelos Fontana
Torezani-Sales, Suellem
Madureira, Amanda Rangel
Silva, Daniel Sesana da
Correa, Camila Renata [UNESP]
Garcia, Jessica Leite [UNESP]
Haese, Douglas
Nogueira, Breno Valentim
Assis, Aricia Leone Evangelista Monteiro de
Lima-Leopoldo, Ana Paula
Leopoldo, Andre Soares
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Espírito Santo (UFES)
Universidade Estadual Paulista (UNESP)
Univ Vila Velha
dc.contributor.author.fl_str_mv Kobi, Jessika Butcovsky Botto Sarter
Matias, Amanda Martins
Gasparini, Patricia Vasconcelos Fontana
Torezani-Sales, Suellem
Madureira, Amanda Rangel
Silva, Daniel Sesana da
Correa, Camila Renata [UNESP]
Garcia, Jessica Leite [UNESP]
Haese, Douglas
Nogueira, Breno Valentim
Assis, Aricia Leone Evangelista Monteiro de
Lima-Leopoldo, Ana Paula
Leopoldo, Andre Soares
dc.subject.por.fl_str_mv diets
inflammation
obesity
oxidative stress
rats
topic diets
inflammation
obesity
oxidative stress
rats
description The study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T11:49:47Z
2023-07-29T11:49:47Z
2023-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.14814/phy2.15635
Physiological Reports. Hoboken: Wiley, v. 11, n. 7, 13 p., 2023.
2051-817X
http://hdl.handle.net/11449/245257
10.14814/phy2.15635
WOS:000968950400001
url http://dx.doi.org/10.14814/phy2.15635
http://hdl.handle.net/11449/245257
identifier_str_mv Physiological Reports. Hoboken: Wiley, v. 11, n. 7, 13 p., 2023.
2051-817X
10.14814/phy2.15635
WOS:000968950400001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Physiological Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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