Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.1186/s12950-018-0184-9 |
Texto Completo: | http://dx.doi.org/10.1186/s12950-018-0184-9 http://hdl.handle.net/11449/170972 |
Resumo: | Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis. The aim of the present study was to investigate whether a statin or diacerein can improve insulin signaling, disease tolerance and survival in sepsis by inhibiting inflammatory pathways. Methods: We investigated the effect of these drugs on survival, tissue insulin signaling and inflammatory pathways in the liver and muscle of rats with sepsis induced by cecal ligation and puncture (CLP). Results: The results showed that administration of medications, with anti-inflammatory ability, to septic animals increased survival and improved disease tolerance and insulin resistance in the liver and muscle. The treatment also attenuated ER stress, NF-κB, JNK activation and restored glucose-6-phosphatase (G6Pase) levels in the liver. Conclusions: Our results indicate that atorvastatin and diacerein treatment can modulate inflammatory pathways and, in parallel, attenuate insulin resistance in sepsis. Since these two drugs have safety profiles and minimal side effects, we suggest that these drugs may be alternative therapies for the prevention or therapies for the treatment of insulin resistance in sepsis, which could potentially reduce mortality in patients with sepsis. |
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Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsisDiacereinInsulin resistanceSepsisStatinBackground: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis. The aim of the present study was to investigate whether a statin or diacerein can improve insulin signaling, disease tolerance and survival in sepsis by inhibiting inflammatory pathways. Methods: We investigated the effect of these drugs on survival, tissue insulin signaling and inflammatory pathways in the liver and muscle of rats with sepsis induced by cecal ligation and puncture (CLP). Results: The results showed that administration of medications, with anti-inflammatory ability, to septic animals increased survival and improved disease tolerance and insulin resistance in the liver and muscle. The treatment also attenuated ER stress, NF-κB, JNK activation and restored glucose-6-phosphatase (G6Pase) levels in the liver. Conclusions: Our results indicate that atorvastatin and diacerein treatment can modulate inflammatory pathways and, in parallel, attenuate insulin resistance in sepsis. Since these two drugs have safety profiles and minimal side effects, we suggest that these drugs may be alternative therapies for the prevention or therapies for the treatment of insulin resistance in sepsis, which could potentially reduce mortality in patients with sepsis.Department of Internal Medicine State University of CampinasDepartment of Biology Science Federal University of PernambucoDepartment of Physical Education São Paulo State University (UNESP) Bioscience InstituteDepartamento de Clínica Médica FCM-UNICAMP Cidade Universitária Zeferino VazDepartment of Physical Education São Paulo State University (UNESP) Bioscience InstituteUniversidade Estadual de Campinas (UNICAMP)Universidade Federal de Pernambuco (UFPE)Universidade Estadual Paulista (Unesp)Da Silva, K. L.C.Camacho, A. P.Mittestainer, F. C.Carvalho, B. M.Santos, A.Guadagnini, D.Oliveira, A. G. [UNESP]Saad, M. J.A.2018-12-11T16:53:11Z2018-12-11T16:53:11Z2018-05-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/s12950-018-0184-9Journal of Inflammation (United Kingdom), v. 15, n. 1, 2018.1476-9255http://hdl.handle.net/11449/17097210.1186/s12950-018-0184-92-s2.0-850466636302-s2.0-85046663630.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Inflammation (United Kingdom)1,101info:eu-repo/semantics/openAccess2023-10-23T06:08:07Zoai:repositorio.unesp.br:11449/170972Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:44:25.197234Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
spellingShingle |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis Da Silva, K. L.C. Diacerein Insulin resistance Sepsis Statin Da Silva, K. L.C. Diacerein Insulin resistance Sepsis Statin |
title_short |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_full |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_fullStr |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_full_unstemmed |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
title_sort |
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis |
author |
Da Silva, K. L.C. |
author_facet |
Da Silva, K. L.C. Da Silva, K. L.C. Camacho, A. P. Mittestainer, F. C. Carvalho, B. M. Santos, A. Guadagnini, D. Oliveira, A. G. [UNESP] Saad, M. J.A. Camacho, A. P. Mittestainer, F. C. Carvalho, B. M. Santos, A. Guadagnini, D. Oliveira, A. G. [UNESP] Saad, M. J.A. |
author_role |
author |
author2 |
Camacho, A. P. Mittestainer, F. C. Carvalho, B. M. Santos, A. Guadagnini, D. Oliveira, A. G. [UNESP] Saad, M. J.A. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Federal de Pernambuco (UFPE) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Da Silva, K. L.C. Camacho, A. P. Mittestainer, F. C. Carvalho, B. M. Santos, A. Guadagnini, D. Oliveira, A. G. [UNESP] Saad, M. J.A. |
dc.subject.por.fl_str_mv |
Diacerein Insulin resistance Sepsis Statin |
topic |
Diacerein Insulin resistance Sepsis Statin |
description |
Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Statins and diacerein have pleiotropic effects, such as the blockage of inflammatory signaling pathways, suggesting that these drugs may be an attractive therapeutic or prophylactic strategy against sepsis. The aim of the present study was to investigate whether a statin or diacerein can improve insulin signaling, disease tolerance and survival in sepsis by inhibiting inflammatory pathways. Methods: We investigated the effect of these drugs on survival, tissue insulin signaling and inflammatory pathways in the liver and muscle of rats with sepsis induced by cecal ligation and puncture (CLP). Results: The results showed that administration of medications, with anti-inflammatory ability, to septic animals increased survival and improved disease tolerance and insulin resistance in the liver and muscle. The treatment also attenuated ER stress, NF-κB, JNK activation and restored glucose-6-phosphatase (G6Pase) levels in the liver. Conclusions: Our results indicate that atorvastatin and diacerein treatment can modulate inflammatory pathways and, in parallel, attenuate insulin resistance in sepsis. Since these two drugs have safety profiles and minimal side effects, we suggest that these drugs may be alternative therapies for the prevention or therapies for the treatment of insulin resistance in sepsis, which could potentially reduce mortality in patients with sepsis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:53:11Z 2018-12-11T16:53:11Z 2018-05-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s12950-018-0184-9 Journal of Inflammation (United Kingdom), v. 15, n. 1, 2018. 1476-9255 http://hdl.handle.net/11449/170972 10.1186/s12950-018-0184-9 2-s2.0-85046663630 2-s2.0-85046663630.pdf |
url |
http://dx.doi.org/10.1186/s12950-018-0184-9 http://hdl.handle.net/11449/170972 |
identifier_str_mv |
Journal of Inflammation (United Kingdom), v. 15, n. 1, 2018. 1476-9255 10.1186/s12950-018-0184-9 2-s2.0-85046663630 2-s2.0-85046663630.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Inflammation (United Kingdom) 1,101 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1822182491646066688 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12950-018-0184-9 |