Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-023-32070-0 http://hdl.handle.net/11449/248580 |
Resumo: | Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood–brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients’ outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality). We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn’t develop delirium (p: 0.69). Levels S100B on admission did not predict delirium in acutely ill elderly patients. Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct). |
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Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort studyDelirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood–brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients’ outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality). We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn’t develop delirium (p: 0.69). Levels S100B on admission did not predict delirium in acutely ill elderly patients. Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct).Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Disciplina de Emergências Clínicas Faculdade de Medicina Universidade de São PauloHospital Universitário Departamento de Medicina Universidade Federal de SergipeHospital de Cínicas de Porto Alegre Universidade Federal do Rio Grande do SulDisciplina de Nefrologia Faculdade de Medicina de Botucatu Universidade Estadual de São PauloDepartamento de Nutrição Faculdade de Saúde Pública Universidade de São PauloFaculdade Israelita de Ciências da Saúde Albert Einstein Hospital Israelita Albert EinsteinCurso de Medicina Faculdade de Odontologia de Bauru Universidade de São Paulo, 9, Dr. Octávio Pinheiro Brisolla, SPDisciplina de Nefrologia Faculdade de Medicina de Botucatu Universidade Estadual de São PauloFAPESP: 2016/14.566-4Universidade de São Paulo (USP)Universidade Federal de Sergipe (UFS)Universidade Federal do Rio Grande do SulUniversidade Estadual Paulista (UNESP)Hospital Israelita Albert Einsteinde Alencar, Júlio César GarciaGarcez, Flávia BarretoPinto, Agnes Araujo SardinhaSilva, Lucas Oliveira Junqueira eSoler, Lucas de Moraes [UNESP]Fernandez, Shirley Steffany MuñozVan Vaisberg, VictorGomez Gomez, Luz MarinaRibeiro, Sandra Maria LimaAvelino-Silva, Thiago JunqueiraSouza, Heraldo Possolo2023-07-29T13:47:57Z2023-07-29T13:47:57Z2023-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-023-32070-0Scientific Reports, v. 13, n. 1, 2023.2045-2322http://hdl.handle.net/11449/24858010.1038/s41598-023-32070-02-s2.0-85150975504Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2023-07-29T13:47:57Zoai:repositorio.unesp.br:11449/248580Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:47:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
title |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
spellingShingle |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study de Alencar, Júlio César Garcia |
title_short |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
title_full |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
title_fullStr |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
title_full_unstemmed |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
title_sort |
Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
author |
de Alencar, Júlio César Garcia |
author_facet |
de Alencar, Júlio César Garcia Garcez, Flávia Barreto Pinto, Agnes Araujo Sardinha Silva, Lucas Oliveira Junqueira e Soler, Lucas de Moraes [UNESP] Fernandez, Shirley Steffany Muñoz Van Vaisberg, Victor Gomez Gomez, Luz Marina Ribeiro, Sandra Maria Lima Avelino-Silva, Thiago Junqueira Souza, Heraldo Possolo |
author_role |
author |
author2 |
Garcez, Flávia Barreto Pinto, Agnes Araujo Sardinha Silva, Lucas Oliveira Junqueira e Soler, Lucas de Moraes [UNESP] Fernandez, Shirley Steffany Muñoz Van Vaisberg, Victor Gomez Gomez, Luz Marina Ribeiro, Sandra Maria Lima Avelino-Silva, Thiago Junqueira Souza, Heraldo Possolo |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de Sergipe (UFS) Universidade Federal do Rio Grande do Sul Universidade Estadual Paulista (UNESP) Hospital Israelita Albert Einstein |
dc.contributor.author.fl_str_mv |
de Alencar, Júlio César Garcia Garcez, Flávia Barreto Pinto, Agnes Araujo Sardinha Silva, Lucas Oliveira Junqueira e Soler, Lucas de Moraes [UNESP] Fernandez, Shirley Steffany Muñoz Van Vaisberg, Victor Gomez Gomez, Luz Marina Ribeiro, Sandra Maria Lima Avelino-Silva, Thiago Junqueira Souza, Heraldo Possolo |
description |
Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood–brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients’ outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality). We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn’t develop delirium (p: 0.69). Levels S100B on admission did not predict delirium in acutely ill elderly patients. Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct). |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:47:57Z 2023-07-29T13:47:57Z 2023-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-023-32070-0 Scientific Reports, v. 13, n. 1, 2023. 2045-2322 http://hdl.handle.net/11449/248580 10.1038/s41598-023-32070-0 2-s2.0-85150975504 |
url |
http://dx.doi.org/10.1038/s41598-023-32070-0 http://hdl.handle.net/11449/248580 |
identifier_str_mv |
Scientific Reports, v. 13, n. 1, 2023. 2045-2322 10.1038/s41598-023-32070-0 2-s2.0-85150975504 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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