DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

• Autor(a) principal: Assencio Almeida Barbosa, Adriana Sierra
• Data de Publicação: 2015
• Outros Autores: Cardoso de Oliveira, Larissa Ragozo [UNESP], Tavares, Francilene Capel [UNESP], Goncalves de Lima, Carlos Roberto [UNESP], Diorio, Suzana Madeira, Calvi, Sueli Aparecida [UNESP], Vilani-Moreno, Fatima Regina, Marques Pereira, Paulo Camara [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.jvat.org/content/21/1/10; http://hdl.handle.net/11449/128323
• topic: Jorge Lobo'disease; Lacazia loboi; Malnutrition; Mice; Genotoxicity; Comet assay

Background: Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods: DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results: The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.