Nitric oxide release using natural rubber latex as matrix

Detalhes bibliográficos
Autor(a) principal: Herculano, Rondinelli Donizetti [UNESP]
Data de Publicação: 2011
Outros Autores: Tzu, Lee Chen, Silva, Cecilia Pereira, Brunello, Carlos Alberto, Queiroz, Álvaro Antônio Alencar de, Kinoshita, Angela, Graeff, Carlos Frederico de Oliveira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
DOI: 10.1590/S1516-14392011005000055
Texto Completo: http://dx.doi.org/10.1590/S1516-14392011005000055
http://hdl.handle.net/11449/6526
Resumo: Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.
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spelling Nitric oxide release using natural rubber latex as matrixnitric oxidelatex membranebiomaterialsdrug delivery systemNitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UNESP Faculdade de Ciências e Letras de Assis Departamento de Ciências BiológicasUniversidade Sagrado CoraçãoUSP Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Departamento de Física e MatemáticaUniversidade Federal de Itajubá Departamento de Física e QuímicaUNESP Faculdade de Ciências Departamento de FísicaUNESP Faculdade de Ciências e Letras de Assis Departamento de Ciências BiológicasUNESP Faculdade de Ciências Departamento de FísicaABM, ABC, ABPolUniversidade Estadual Paulista (Unesp)Universidade Sagrado CoraçãoUniversidade de São Paulo (USP)Universidade Federal de Itajubá (UNIFEI)Herculano, Rondinelli Donizetti [UNESP]Tzu, Lee ChenSilva, Cecilia PereiraBrunello, Carlos AlbertoQueiroz, Álvaro Antônio Alencar deKinoshita, AngelaGraeff, Carlos Frederico de Oliveira [UNESP]2014-05-20T13:22:18Z2014-05-20T13:22:18Z2011-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article355-359application/pdfhttp://dx.doi.org/10.1590/S1516-14392011005000055Materials Research. ABM, ABC, ABPol, v. 14, n. 3, p. 355-359, 2011.1516-1439http://hdl.handle.net/11449/652610.1590/S1516-14392011005000055S1516-14392011000300012WOS:000296277000012S1516-14392011000300012.pdf0000-0003-0162-8273SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Research1.1030,398info:eu-repo/semantics/openAccess2024-06-13T17:38:31Zoai:repositorio.unesp.br:11449/6526Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:29:48.989577Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Nitric oxide release using natural rubber latex as matrix
title Nitric oxide release using natural rubber latex as matrix
spellingShingle Nitric oxide release using natural rubber latex as matrix
Nitric oxide release using natural rubber latex as matrix
Herculano, Rondinelli Donizetti [UNESP]
nitric oxide
latex membrane
biomaterials
drug delivery system
Herculano, Rondinelli Donizetti [UNESP]
nitric oxide
latex membrane
biomaterials
drug delivery system
title_short Nitric oxide release using natural rubber latex as matrix
title_full Nitric oxide release using natural rubber latex as matrix
title_fullStr Nitric oxide release using natural rubber latex as matrix
Nitric oxide release using natural rubber latex as matrix
title_full_unstemmed Nitric oxide release using natural rubber latex as matrix
Nitric oxide release using natural rubber latex as matrix
title_sort Nitric oxide release using natural rubber latex as matrix
author Herculano, Rondinelli Donizetti [UNESP]
author_facet Herculano, Rondinelli Donizetti [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
Tzu, Lee Chen
Silva, Cecilia Pereira
Brunello, Carlos Alberto
Queiroz, Álvaro Antônio Alencar de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
Tzu, Lee Chen
Silva, Cecilia Pereira
Brunello, Carlos Alberto
Queiroz, Álvaro Antônio Alencar de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
author_role author
author2 Tzu, Lee Chen
Silva, Cecilia Pereira
Brunello, Carlos Alberto
Queiroz, Álvaro Antônio Alencar de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Sagrado Coração
Universidade de São Paulo (USP)
Universidade Federal de Itajubá (UNIFEI)
dc.contributor.author.fl_str_mv Herculano, Rondinelli Donizetti [UNESP]
Tzu, Lee Chen
Silva, Cecilia Pereira
Brunello, Carlos Alberto
Queiroz, Álvaro Antônio Alencar de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
dc.subject.por.fl_str_mv nitric oxide
latex membrane
biomaterials
drug delivery system
topic nitric oxide
latex membrane
biomaterials
drug delivery system
description Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
2014-05-20T13:22:18Z
2014-05-20T13:22:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-14392011005000055
Materials Research. ABM, ABC, ABPol, v. 14, n. 3, p. 355-359, 2011.
1516-1439
http://hdl.handle.net/11449/6526
10.1590/S1516-14392011005000055
S1516-14392011000300012
WOS:000296277000012
S1516-14392011000300012.pdf
0000-0003-0162-8273
url http://dx.doi.org/10.1590/S1516-14392011005000055
http://hdl.handle.net/11449/6526
identifier_str_mv Materials Research. ABM, ABC, ABPol, v. 14, n. 3, p. 355-359, 2011.
1516-1439
10.1590/S1516-14392011005000055
S1516-14392011000300012
WOS:000296277000012
S1516-14392011000300012.pdf
0000-0003-0162-8273
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials Research
1.103
0,398
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 355-359
application/pdf
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1822182327781949440
dc.identifier.doi.none.fl_str_mv 10.1590/S1516-14392011005000055

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