Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters

Detalhes bibliográficos
Autor(a) principal: Sinzato, Yuri Karen [UNESP]
Data de Publicação: 2012
Outros Autores: Volpato, Gustavo Tadeu [UNESP], Iessi, Isabela Lovizutto [UNESP], Bueno, Aline [UNESP], Calderon, Iracema de Mattos Paranhos [UNESP], Rudge, Marilza Vieira Cunha [UNESP], Damasceno, Débora Cristina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2012/108163
http://hdl.handle.net/11449/12272
Resumo: The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.
id UNSP_b6c948fffe9dd531349bd7351018af32
oai_identifier_str oai:repositorio.unesp.br:11449/12272
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal ParametersThe aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista Unesp, Dept Gynecol & Obstet, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Botucatu, SP, BrazilMato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, BR-78600000 Barra do Garcas, MG, BrazilUniv Estadual Paulista Unesp, Dept Gynecol & Obstet, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Botucatu, SP, BrazilFAPESP: 06/03768-3Hindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Universidade Federal de Mato Grosso (UFMT)Sinzato, Yuri Karen [UNESP]Volpato, Gustavo Tadeu [UNESP]Iessi, Isabela Lovizutto [UNESP]Bueno, Aline [UNESP]Calderon, Iracema de Mattos Paranhos [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Damasceno, Débora Cristina [UNESP]2014-05-20T13:35:39Z2014-05-20T13:35:39Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1155/2012/108163Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 7, 2012.1687-5214http://hdl.handle.net/11449/1227210.1155/2012/108163WOS:000305622600001WOS000305622600001.pdf067938762260474367586803888350780000-0002-9227-832XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental Diabetes Researchinfo:eu-repo/semantics/openAccess2024-08-16T14:07:23Zoai:repositorio.unesp.br:11449/12272Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
title Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
spellingShingle Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
Sinzato, Yuri Karen [UNESP]
title_short Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
title_full Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
title_fullStr Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
title_full_unstemmed Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
title_sort Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
author Sinzato, Yuri Karen [UNESP]
author_facet Sinzato, Yuri Karen [UNESP]
Volpato, Gustavo Tadeu [UNESP]
Iessi, Isabela Lovizutto [UNESP]
Bueno, Aline [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Damasceno, Débora Cristina [UNESP]
author_role author
author2 Volpato, Gustavo Tadeu [UNESP]
Iessi, Isabela Lovizutto [UNESP]
Bueno, Aline [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Damasceno, Débora Cristina [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso (UFMT)
dc.contributor.author.fl_str_mv Sinzato, Yuri Karen [UNESP]
Volpato, Gustavo Tadeu [UNESP]
Iessi, Isabela Lovizutto [UNESP]
Bueno, Aline [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Damasceno, Débora Cristina [UNESP]
description The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2014-05-20T13:35:39Z
2014-05-20T13:35:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2012/108163
Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 7, 2012.
1687-5214
http://hdl.handle.net/11449/12272
10.1155/2012/108163
WOS:000305622600001
WOS000305622600001.pdf
0679387622604743
6758680388835078
0000-0002-9227-832X
url http://dx.doi.org/10.1155/2012/108163
http://hdl.handle.net/11449/12272
identifier_str_mv Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 7, 2012.
1687-5214
10.1155/2012/108163
WOS:000305622600001
WOS000305622600001.pdf
0679387622604743
6758680388835078
0000-0002-9227-832X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Experimental Diabetes Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128166888210432