Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment

Detalhes bibliográficos
Autor(a) principal: Floriano, Juliana Ferreira [UNESP]
Data de Publicação: 2018
Outros Autores: de Barros, Natan Roberto [UNESP], Cinman, José Luiz Ferreira [UNESP], da Silva, Rosangela Gonçalves [UNESP], Loffredo, Augusto Villela [UNESP], Borges, Felipe Azevedo [UNESP], Norberto, Ana Maria Queiros, Chagas, Ana Laura Destro, Garms, Bruna Cambraia [UNESP], de Oliveira Graeff, Carlos Frederico [UNESP], Herculano, Rondinelli Donizetti [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10924-017-1127-x
http://hdl.handle.net/11449/179265
Resumo: Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery.
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spelling Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis TreatmentAnti-inflammatoryBiomaterialKetoprofenNatural rubber latexTransdermal drug delivery systemKetoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenueInstitute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú RoadSchool of Sciences Humanities and Languages São Paulo State University (UNESP), 2100 Dom Antônio AvenueFaculty of Medicine São Paulo University (USP), 3900 Bandeirantes AvenueUFTM – ICBN, 330 Manoel Mendes Square, Biochemistry SectionDepartment of physics School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenuePharmaceutical Science Center Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetSchool of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenueInstitute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú RoadSchool of Sciences Humanities and Languages São Paulo State University (UNESP), 2100 Dom Antônio AvenueDepartment of physics School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenuePharmaceutical Science Center Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetFAPESP: 2014/17526-8CAPES: 470261/2012-9Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)UFTM – ICBNFloriano, Juliana Ferreira [UNESP]de Barros, Natan Roberto [UNESP]Cinman, José Luiz Ferreira [UNESP]da Silva, Rosangela Gonçalves [UNESP]Loffredo, Augusto Villela [UNESP]Borges, Felipe Azevedo [UNESP]Norberto, Ana Maria QueirosChagas, Ana Laura DestroGarms, Bruna Cambraia [UNESP]de Oliveira Graeff, Carlos Frederico [UNESP]Herculano, Rondinelli Donizetti [UNESP]2018-12-11T17:34:26Z2018-12-11T17:34:26Z2018-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2281-2289application/pdfhttp://dx.doi.org/10.1007/s10924-017-1127-xJournal of Polymers and the Environment, v. 26, n. 6, p. 2281-2289, 2018.1566-2543http://hdl.handle.net/11449/17926510.1007/s10924-017-1127-x2-s2.0-850308442142-s2.0-85030844214.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Polymers and the Environment0,562info:eu-repo/semantics/openAccess2024-06-13T17:38:42Zoai:repositorio.unesp.br:11449/179265Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:18:24.950809Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
title Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
spellingShingle Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
Floriano, Juliana Ferreira [UNESP]
Anti-inflammatory
Biomaterial
Ketoprofen
Natural rubber latex
Transdermal drug delivery system
title_short Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
title_full Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
title_fullStr Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
title_full_unstemmed Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
title_sort Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
author Floriano, Juliana Ferreira [UNESP]
author_facet Floriano, Juliana Ferreira [UNESP]
de Barros, Natan Roberto [UNESP]
Cinman, José Luiz Ferreira [UNESP]
da Silva, Rosangela Gonçalves [UNESP]
Loffredo, Augusto Villela [UNESP]
Borges, Felipe Azevedo [UNESP]
Norberto, Ana Maria Queiros
Chagas, Ana Laura Destro
Garms, Bruna Cambraia [UNESP]
de Oliveira Graeff, Carlos Frederico [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
author_role author
author2 de Barros, Natan Roberto [UNESP]
Cinman, José Luiz Ferreira [UNESP]
da Silva, Rosangela Gonçalves [UNESP]
Loffredo, Augusto Villela [UNESP]
Borges, Felipe Azevedo [UNESP]
Norberto, Ana Maria Queiros
Chagas, Ana Laura Destro
Garms, Bruna Cambraia [UNESP]
de Oliveira Graeff, Carlos Frederico [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
UFTM – ICBN
dc.contributor.author.fl_str_mv Floriano, Juliana Ferreira [UNESP]
de Barros, Natan Roberto [UNESP]
Cinman, José Luiz Ferreira [UNESP]
da Silva, Rosangela Gonçalves [UNESP]
Loffredo, Augusto Villela [UNESP]
Borges, Felipe Azevedo [UNESP]
Norberto, Ana Maria Queiros
Chagas, Ana Laura Destro
Garms, Bruna Cambraia [UNESP]
de Oliveira Graeff, Carlos Frederico [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
dc.subject.por.fl_str_mv Anti-inflammatory
Biomaterial
Ketoprofen
Natural rubber latex
Transdermal drug delivery system
topic Anti-inflammatory
Biomaterial
Ketoprofen
Natural rubber latex
Transdermal drug delivery system
description Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:34:26Z
2018-12-11T17:34:26Z
2018-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10924-017-1127-x
Journal of Polymers and the Environment, v. 26, n. 6, p. 2281-2289, 2018.
1566-2543
http://hdl.handle.net/11449/179265
10.1007/s10924-017-1127-x
2-s2.0-85030844214
2-s2.0-85030844214.pdf
url http://dx.doi.org/10.1007/s10924-017-1127-x
http://hdl.handle.net/11449/179265
identifier_str_mv Journal of Polymers and the Environment, v. 26, n. 6, p. 2281-2289, 2018.
1566-2543
10.1007/s10924-017-1127-x
2-s2.0-85030844214
2-s2.0-85030844214.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Polymers and the Environment
0,562
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2281-2289
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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