Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10924-017-1127-x http://hdl.handle.net/11449/179265 |
Resumo: | Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery. |
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Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis TreatmentAnti-inflammatoryBiomaterialKetoprofenNatural rubber latexTransdermal drug delivery systemKetoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenueInstitute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú RoadSchool of Sciences Humanities and Languages São Paulo State University (UNESP), 2100 Dom Antônio AvenueFaculty of Medicine São Paulo University (USP), 3900 Bandeirantes AvenueUFTM – ICBN, 330 Manoel Mendes Square, Biochemistry SectionDepartment of physics School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenuePharmaceutical Science Center Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetSchool of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenueInstitute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú RoadSchool of Sciences Humanities and Languages São Paulo State University (UNESP), 2100 Dom Antônio AvenueDepartment of physics School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube AvenuePharmaceutical Science Center Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetFAPESP: 2014/17526-8CAPES: 470261/2012-9Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)UFTM – ICBNFloriano, Juliana Ferreira [UNESP]de Barros, Natan Roberto [UNESP]Cinman, José Luiz Ferreira [UNESP]da Silva, Rosangela Gonçalves [UNESP]Loffredo, Augusto Villela [UNESP]Borges, Felipe Azevedo [UNESP]Norberto, Ana Maria QueirosChagas, Ana Laura DestroGarms, Bruna Cambraia [UNESP]de Oliveira Graeff, Carlos Frederico [UNESP]Herculano, Rondinelli Donizetti [UNESP]2018-12-11T17:34:26Z2018-12-11T17:34:26Z2018-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2281-2289application/pdfhttp://dx.doi.org/10.1007/s10924-017-1127-xJournal of Polymers and the Environment, v. 26, n. 6, p. 2281-2289, 2018.1566-2543http://hdl.handle.net/11449/17926510.1007/s10924-017-1127-x2-s2.0-850308442142-s2.0-85030844214.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Polymers and the Environment0,562info:eu-repo/semantics/openAccess2024-06-13T17:38:42Zoai:repositorio.unesp.br:11449/179265Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:18:24.950809Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
title |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
spellingShingle |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment Floriano, Juliana Ferreira [UNESP] Anti-inflammatory Biomaterial Ketoprofen Natural rubber latex Transdermal drug delivery system |
title_short |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
title_full |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
title_fullStr |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
title_full_unstemmed |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
title_sort |
Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment |
author |
Floriano, Juliana Ferreira [UNESP] |
author_facet |
Floriano, Juliana Ferreira [UNESP] de Barros, Natan Roberto [UNESP] Cinman, José Luiz Ferreira [UNESP] da Silva, Rosangela Gonçalves [UNESP] Loffredo, Augusto Villela [UNESP] Borges, Felipe Azevedo [UNESP] Norberto, Ana Maria Queiros Chagas, Ana Laura Destro Garms, Bruna Cambraia [UNESP] de Oliveira Graeff, Carlos Frederico [UNESP] Herculano, Rondinelli Donizetti [UNESP] |
author_role |
author |
author2 |
de Barros, Natan Roberto [UNESP] Cinman, José Luiz Ferreira [UNESP] da Silva, Rosangela Gonçalves [UNESP] Loffredo, Augusto Villela [UNESP] Borges, Felipe Azevedo [UNESP] Norberto, Ana Maria Queiros Chagas, Ana Laura Destro Garms, Bruna Cambraia [UNESP] de Oliveira Graeff, Carlos Frederico [UNESP] Herculano, Rondinelli Donizetti [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) UFTM – ICBN |
dc.contributor.author.fl_str_mv |
Floriano, Juliana Ferreira [UNESP] de Barros, Natan Roberto [UNESP] Cinman, José Luiz Ferreira [UNESP] da Silva, Rosangela Gonçalves [UNESP] Loffredo, Augusto Villela [UNESP] Borges, Felipe Azevedo [UNESP] Norberto, Ana Maria Queiros Chagas, Ana Laura Destro Garms, Bruna Cambraia [UNESP] de Oliveira Graeff, Carlos Frederico [UNESP] Herculano, Rondinelli Donizetti [UNESP] |
dc.subject.por.fl_str_mv |
Anti-inflammatory Biomaterial Ketoprofen Natural rubber latex Transdermal drug delivery system |
topic |
Anti-inflammatory Biomaterial Ketoprofen Natural rubber latex Transdermal drug delivery system |
description |
Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:34:26Z 2018-12-11T17:34:26Z 2018-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10924-017-1127-x Journal of Polymers and the Environment, v. 26, n. 6, p. 2281-2289, 2018. 1566-2543 http://hdl.handle.net/11449/179265 10.1007/s10924-017-1127-x 2-s2.0-85030844214 2-s2.0-85030844214.pdf |
url |
http://dx.doi.org/10.1007/s10924-017-1127-x http://hdl.handle.net/11449/179265 |
identifier_str_mv |
Journal of Polymers and the Environment, v. 26, n. 6, p. 2281-2289, 2018. 1566-2543 10.1007/s10924-017-1127-x 2-s2.0-85030844214 2-s2.0-85030844214.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Polymers and the Environment 0,562 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2281-2289 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129307153793024 |