Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment

Detalhes bibliográficos
Autor(a) principal: Morise, B. T. [UNESP]
Data de Publicação: 2019
Outros Autores: Chagas, A. L.D. [UNESP], Barros, N. R. [UNESP], Miranda, M. C.R. [UNESP], Borges, F. A. [UNESP], Gemeinder, J. L.P. [UNESP], Silva, R. G. [UNESP], Paulino, C. G. [UNESP], Herculano, R. D. [UNESP], Norberto, A. M.Q.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/00914037.2018.1506984
http://hdl.handle.net/11449/186957
Resumo: Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.
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spelling Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatmentbiomaterialnatural rubber latexscopolamineSialorrheasustained releaseSialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)Faculty of Medicine São Paulo University (USP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)FAPESP: 2011/17411-8FAPESP: PADC 2018/01-ICNPq: Process 470261/2012-9FAPESP: Processes 2014/17526-8Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Morise, B. T. [UNESP]Chagas, A. L.D. [UNESP]Barros, N. R. [UNESP]Miranda, M. C.R. [UNESP]Borges, F. A. [UNESP]Gemeinder, J. L.P. [UNESP]Silva, R. G. [UNESP]Paulino, C. G. [UNESP]Herculano, R. D. [UNESP]Norberto, A. M.Q.2019-10-06T15:21:00Z2019-10-06T15:21:00Z2019-09-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article788-795http://dx.doi.org/10.1080/00914037.2018.1506984International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019.1563-535X0091-4037http://hdl.handle.net/11449/18695710.1080/00914037.2018.15069842-s2.0-85054878053Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Polymeric Materials and Polymeric Biomaterialsinfo:eu-repo/semantics/openAccess2021-10-23T02:05:27Zoai:repositorio.unesp.br:11449/186957Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:11:25.195406Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
title Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
spellingShingle Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
Morise, B. T. [UNESP]
biomaterial
natural rubber latex
scopolamine
Sialorrhea
sustained release
title_short Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
title_full Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
title_fullStr Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
title_full_unstemmed Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
title_sort Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
author Morise, B. T. [UNESP]
author_facet Morise, B. T. [UNESP]
Chagas, A. L.D. [UNESP]
Barros, N. R. [UNESP]
Miranda, M. C.R. [UNESP]
Borges, F. A. [UNESP]
Gemeinder, J. L.P. [UNESP]
Silva, R. G. [UNESP]
Paulino, C. G. [UNESP]
Herculano, R. D. [UNESP]
Norberto, A. M.Q.
author_role author
author2 Chagas, A. L.D. [UNESP]
Barros, N. R. [UNESP]
Miranda, M. C.R. [UNESP]
Borges, F. A. [UNESP]
Gemeinder, J. L.P. [UNESP]
Silva, R. G. [UNESP]
Paulino, C. G. [UNESP]
Herculano, R. D. [UNESP]
Norberto, A. M.Q.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Morise, B. T. [UNESP]
Chagas, A. L.D. [UNESP]
Barros, N. R. [UNESP]
Miranda, M. C.R. [UNESP]
Borges, F. A. [UNESP]
Gemeinder, J. L.P. [UNESP]
Silva, R. G. [UNESP]
Paulino, C. G. [UNESP]
Herculano, R. D. [UNESP]
Norberto, A. M.Q.
dc.subject.por.fl_str_mv biomaterial
natural rubber latex
scopolamine
Sialorrhea
sustained release
topic biomaterial
natural rubber latex
scopolamine
Sialorrhea
sustained release
description Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T15:21:00Z
2019-10-06T15:21:00Z
2019-09-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/00914037.2018.1506984
International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019.
1563-535X
0091-4037
http://hdl.handle.net/11449/186957
10.1080/00914037.2018.1506984
2-s2.0-85054878053
url http://dx.doi.org/10.1080/00914037.2018.1506984
http://hdl.handle.net/11449/186957
identifier_str_mv International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019.
1563-535X
0091-4037
10.1080/00914037.2018.1506984
2-s2.0-85054878053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Polymeric Materials and Polymeric Biomaterials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 788-795
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128330009935872