Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/00914037.2018.1506984 http://hdl.handle.net/11449/186957 |
Resumo: | Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea. |
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Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatmentbiomaterialnatural rubber latexscopolamineSialorrheasustained releaseSialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)Faculty of Medicine São Paulo University (USP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)FAPESP: 2011/17411-8FAPESP: PADC 2018/01-ICNPq: Process 470261/2012-9FAPESP: Processes 2014/17526-8Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Morise, B. T. [UNESP]Chagas, A. L.D. [UNESP]Barros, N. R. [UNESP]Miranda, M. C.R. [UNESP]Borges, F. A. [UNESP]Gemeinder, J. L.P. [UNESP]Silva, R. G. [UNESP]Paulino, C. G. [UNESP]Herculano, R. D. [UNESP]Norberto, A. M.Q.2019-10-06T15:21:00Z2019-10-06T15:21:00Z2019-09-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article788-795http://dx.doi.org/10.1080/00914037.2018.1506984International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019.1563-535X0091-4037http://hdl.handle.net/11449/18695710.1080/00914037.2018.15069842-s2.0-85054878053Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Polymeric Materials and Polymeric Biomaterialsinfo:eu-repo/semantics/openAccess2021-10-23T02:05:27Zoai:repositorio.unesp.br:11449/186957Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:11:25.195406Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
title |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
spellingShingle |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment Morise, B. T. [UNESP] biomaterial natural rubber latex scopolamine Sialorrhea sustained release |
title_short |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
title_full |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
title_fullStr |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
title_full_unstemmed |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
title_sort |
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment |
author |
Morise, B. T. [UNESP] |
author_facet |
Morise, B. T. [UNESP] Chagas, A. L.D. [UNESP] Barros, N. R. [UNESP] Miranda, M. C.R. [UNESP] Borges, F. A. [UNESP] Gemeinder, J. L.P. [UNESP] Silva, R. G. [UNESP] Paulino, C. G. [UNESP] Herculano, R. D. [UNESP] Norberto, A. M.Q. |
author_role |
author |
author2 |
Chagas, A. L.D. [UNESP] Barros, N. R. [UNESP] Miranda, M. C.R. [UNESP] Borges, F. A. [UNESP] Gemeinder, J. L.P. [UNESP] Silva, R. G. [UNESP] Paulino, C. G. [UNESP] Herculano, R. D. [UNESP] Norberto, A. M.Q. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Morise, B. T. [UNESP] Chagas, A. L.D. [UNESP] Barros, N. R. [UNESP] Miranda, M. C.R. [UNESP] Borges, F. A. [UNESP] Gemeinder, J. L.P. [UNESP] Silva, R. G. [UNESP] Paulino, C. G. [UNESP] Herculano, R. D. [UNESP] Norberto, A. M.Q. |
dc.subject.por.fl_str_mv |
biomaterial natural rubber latex scopolamine Sialorrhea sustained release |
topic |
biomaterial natural rubber latex scopolamine Sialorrhea sustained release |
description |
Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:21:00Z 2019-10-06T15:21:00Z 2019-09-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/00914037.2018.1506984 International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019. 1563-535X 0091-4037 http://hdl.handle.net/11449/186957 10.1080/00914037.2018.1506984 2-s2.0-85054878053 |
url |
http://dx.doi.org/10.1080/00914037.2018.1506984 http://hdl.handle.net/11449/186957 |
identifier_str_mv |
International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019. 1563-535X 0091-4037 10.1080/00914037.2018.1506984 2-s2.0-85054878053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Polymeric Materials and Polymeric Biomaterials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
788-795 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128330009935872 |