Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pntd.0010254 http://hdl.handle.net/11449/230662 |
Resumo: | Rabies transmitted by wildlife is now the main source of human rabies in the Americas. The common marmoset, Callithrix jacchus, is considered a reservoir of rabies causing sporadic and unpredictable human deaths in Brazil, but the extent of the spillover risk to humans remains unknown. In this study, we described the spatiotemporal dynamics of rabies affect-ing C. jacchus reported to Brazil’s Ministry of Health passive surveillance system between 2008 and 2020, and combined ecological niche modelling with C. jacchus occurrence data to predict its suitable habitat. Our results show that 67 outbreaks (91 cases) of rabies affect-ing C. jacchus were reported by 41 municipalities between January 2008 and October 2020, with a mean of 5 outbreaks/year [range: 1–14]. The maximum number of outbreaks and municipalities reporting cases occurred in 2018, coinciding with higher surveillance of primate deaths due to Yellow Fever. A mean of 3 [1–9] new municipalities reported outbreaks yearly, suggesting potential spatial expansions of the C. jacchus variant in northeastern Brazil and emerging rabies spillover from vampire bat Desmodus rotundus to C. jacchus in the north and south. Outbreaks were concentrated in the states of Ceará (72%) and Pernam-buco (16%) up to 2012, but are now reported in Piauí since 2013, in Bahia since 2017 (D. rotundus’ antigenic variant, AgV3) and in Rio de Janeiro since 2019 (AgV3). Besides confirming suitable habitat for this primate in the northeast and the east coast of Brazil, our Maximum Entropy model also predicted suitable habitat on the north and the west states of the country but predicted low habitat suitability among inland municipalities of the Caatinga biome reporting rabies. Our findings revealed new areas reporting rabies infecting C. jac-chus, highlighting the need to implement strategies limiting spillover to humans and to better understand the drivers of C. jacchus rabies dynamics. |
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Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in BrazilRabies transmitted by wildlife is now the main source of human rabies in the Americas. The common marmoset, Callithrix jacchus, is considered a reservoir of rabies causing sporadic and unpredictable human deaths in Brazil, but the extent of the spillover risk to humans remains unknown. In this study, we described the spatiotemporal dynamics of rabies affect-ing C. jacchus reported to Brazil’s Ministry of Health passive surveillance system between 2008 and 2020, and combined ecological niche modelling with C. jacchus occurrence data to predict its suitable habitat. Our results show that 67 outbreaks (91 cases) of rabies affect-ing C. jacchus were reported by 41 municipalities between January 2008 and October 2020, with a mean of 5 outbreaks/year [range: 1–14]. The maximum number of outbreaks and municipalities reporting cases occurred in 2018, coinciding with higher surveillance of primate deaths due to Yellow Fever. A mean of 3 [1–9] new municipalities reported outbreaks yearly, suggesting potential spatial expansions of the C. jacchus variant in northeastern Brazil and emerging rabies spillover from vampire bat Desmodus rotundus to C. jacchus in the north and south. Outbreaks were concentrated in the states of Ceará (72%) and Pernam-buco (16%) up to 2012, but are now reported in Piauí since 2013, in Bahia since 2017 (D. rotundus’ antigenic variant, AgV3) and in Rio de Janeiro since 2019 (AgV3). Besides confirming suitable habitat for this primate in the northeast and the east coast of Brazil, our Maximum Entropy model also predicted suitable habitat on the north and the west states of the country but predicted low habitat suitability among inland municipalities of the Caatinga biome reporting rabies. Our findings revealed new areas reporting rabies infecting C. jac-chus, highlighting the need to implement strategies limiting spillover to humans and to better understand the drivers of C. jacchus rabies dynamics.Doctorado en Medicina de la Conservación y Centro de Investigación para la Sustentabilidad Facultad de Ciencias de la Vida Universidad Andres Bello, República 440MIVEGEC IRD CNRS Université de MontpellierDepartamento Higiene Veterinária e Saúde Pública Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Júlio de Mesquita FilhoDepartment of Veterinary Pathobiology College of Veterinary Medicine University of MissouriDepartment of Public Health School of Health Professions University of MissouriInstitute of Humanities Arts and Sciences Federal University of Southern Bahia-UFSBSecretaria de Vigilância em Saúde (SVS) Ministério da SaúdeSecretaria de saúde de PernambucoPrograma Estadual de Vigilância de Epizootia Secretaria de saúde de Rio Grande do NorteSetor de Psicobiologia Departamento de Fisiología Universidade Federal do Río Grande do NorteBiodiversity Institute University of KansasInstituto ButantanRetired Researcher Instituto BiológicoDepartamento Higiene Veterinária e Saúde Pública Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Júlio de Mesquita FilhoUniversidad Andres BelloUniversité de MontpellierUniversidade Estadual Paulista (UNESP)University of MissouriUniversidade Federal de Sergipe (UFS)Ministério da SaúdeSecretaria de saúde de PernambucoSecretaria de saúde de Rio Grande do NorteSetor de PsicobiologiaUniversity of KansasInstituto ButantanInstituto BiológicoBenavides, Julio A. [UNESP]Raghavan, Ram K.Boere, VannerRocha, SileneWada, Marcelo Y.Vargas, AlexanderVoietta, FernandaE Silva, Ita de OliveiraLeal, Silvanade Castro, AleneArruda, Maria de FatimaPeterson, A. TownsendMegid, Jane [UNESP]Carrieri, Maria LuizaKotait, Ivanete2022-04-29T08:41:25Z2022-04-29T08:41:25Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pntd.0010254PLoS Neglected Tropical Diseases, v. 16, n. 3, 2022.1935-27351935-2727http://hdl.handle.net/11449/23066210.1371/journal.pntd.00102542-s2.0-85127408615Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/openAccess2022-04-29T08:41:25Zoai:repositorio.unesp.br:11449/230662Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:25.532210Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
title |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
spellingShingle |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil Benavides, Julio A. [UNESP] |
title_short |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
title_full |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
title_fullStr |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
title_full_unstemmed |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
title_sort |
Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil |
author |
Benavides, Julio A. [UNESP] |
author_facet |
Benavides, Julio A. [UNESP] Raghavan, Ram K. Boere, Vanner Rocha, Silene Wada, Marcelo Y. Vargas, Alexander Voietta, Fernanda E Silva, Ita de Oliveira Leal, Silvana de Castro, Alene Arruda, Maria de Fatima Peterson, A. Townsend Megid, Jane [UNESP] Carrieri, Maria Luiza Kotait, Ivanete |
author_role |
author |
author2 |
Raghavan, Ram K. Boere, Vanner Rocha, Silene Wada, Marcelo Y. Vargas, Alexander Voietta, Fernanda E Silva, Ita de Oliveira Leal, Silvana de Castro, Alene Arruda, Maria de Fatima Peterson, A. Townsend Megid, Jane [UNESP] Carrieri, Maria Luiza Kotait, Ivanete |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidad Andres Bello Université de Montpellier Universidade Estadual Paulista (UNESP) University of Missouri Universidade Federal de Sergipe (UFS) Ministério da Saúde Secretaria de saúde de Pernambuco Secretaria de saúde de Rio Grande do Norte Setor de Psicobiologia University of Kansas Instituto Butantan Instituto Biológico |
dc.contributor.author.fl_str_mv |
Benavides, Julio A. [UNESP] Raghavan, Ram K. Boere, Vanner Rocha, Silene Wada, Marcelo Y. Vargas, Alexander Voietta, Fernanda E Silva, Ita de Oliveira Leal, Silvana de Castro, Alene Arruda, Maria de Fatima Peterson, A. Townsend Megid, Jane [UNESP] Carrieri, Maria Luiza Kotait, Ivanete |
description |
Rabies transmitted by wildlife is now the main source of human rabies in the Americas. The common marmoset, Callithrix jacchus, is considered a reservoir of rabies causing sporadic and unpredictable human deaths in Brazil, but the extent of the spillover risk to humans remains unknown. In this study, we described the spatiotemporal dynamics of rabies affect-ing C. jacchus reported to Brazil’s Ministry of Health passive surveillance system between 2008 and 2020, and combined ecological niche modelling with C. jacchus occurrence data to predict its suitable habitat. Our results show that 67 outbreaks (91 cases) of rabies affect-ing C. jacchus were reported by 41 municipalities between January 2008 and October 2020, with a mean of 5 outbreaks/year [range: 1–14]. The maximum number of outbreaks and municipalities reporting cases occurred in 2018, coinciding with higher surveillance of primate deaths due to Yellow Fever. A mean of 3 [1–9] new municipalities reported outbreaks yearly, suggesting potential spatial expansions of the C. jacchus variant in northeastern Brazil and emerging rabies spillover from vampire bat Desmodus rotundus to C. jacchus in the north and south. Outbreaks were concentrated in the states of Ceará (72%) and Pernam-buco (16%) up to 2012, but are now reported in Piauí since 2013, in Bahia since 2017 (D. rotundus’ antigenic variant, AgV3) and in Rio de Janeiro since 2019 (AgV3). Besides confirming suitable habitat for this primate in the northeast and the east coast of Brazil, our Maximum Entropy model also predicted suitable habitat on the north and the west states of the country but predicted low habitat suitability among inland municipalities of the Caatinga biome reporting rabies. Our findings revealed new areas reporting rabies infecting C. jac-chus, highlighting the need to implement strategies limiting spillover to humans and to better understand the drivers of C. jacchus rabies dynamics. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:41:25Z 2022-04-29T08:41:25Z 2022-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pntd.0010254 PLoS Neglected Tropical Diseases, v. 16, n. 3, 2022. 1935-2735 1935-2727 http://hdl.handle.net/11449/230662 10.1371/journal.pntd.0010254 2-s2.0-85127408615 |
url |
http://dx.doi.org/10.1371/journal.pntd.0010254 http://hdl.handle.net/11449/230662 |
identifier_str_mv |
PLoS Neglected Tropical Diseases, v. 16, n. 3, 2022. 1935-2735 1935-2727 10.1371/journal.pntd.0010254 2-s2.0-85127408615 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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PLoS Neglected Tropical Diseases |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808128895676841984 |