Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil

Detalhes bibliográficos
Autor(a) principal: Benavides, Julio A. [UNESP]
Data de Publicação: 2022
Outros Autores: Raghavan, Ram K., Boere, Vanner, Rocha, Silene, Wada, Marcelo Y., Vargas, Alexander, Voietta, Fernanda, E Silva, Ita de Oliveira, Leal, Silvana, de Castro, Alene, Arruda, Maria de Fatima, Peterson, A. Townsend, Megid, Jane [UNESP], Carrieri, Maria Luiza, Kotait, Ivanete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1371/journal.pntd.0010254
http://hdl.handle.net/11449/230662
Resumo: Rabies transmitted by wildlife is now the main source of human rabies in the Americas. The common marmoset, Callithrix jacchus, is considered a reservoir of rabies causing sporadic and unpredictable human deaths in Brazil, but the extent of the spillover risk to humans remains unknown. In this study, we described the spatiotemporal dynamics of rabies affect-ing C. jacchus reported to Brazil’s Ministry of Health passive surveillance system between 2008 and 2020, and combined ecological niche modelling with C. jacchus occurrence data to predict its suitable habitat. Our results show that 67 outbreaks (91 cases) of rabies affect-ing C. jacchus were reported by 41 municipalities between January 2008 and October 2020, with a mean of 5 outbreaks/year [range: 1–14]. The maximum number of outbreaks and municipalities reporting cases occurred in 2018, coinciding with higher surveillance of primate deaths due to Yellow Fever. A mean of 3 [1–9] new municipalities reported outbreaks yearly, suggesting potential spatial expansions of the C. jacchus variant in northeastern Brazil and emerging rabies spillover from vampire bat Desmodus rotundus to C. jacchus in the north and south. Outbreaks were concentrated in the states of Ceará (72%) and Pernam-buco (16%) up to 2012, but are now reported in Piauí since 2013, in Bahia since 2017 (D. rotundus’ antigenic variant, AgV3) and in Rio de Janeiro since 2019 (AgV3). Besides confirming suitable habitat for this primate in the northeast and the east coast of Brazil, our Maximum Entropy model also predicted suitable habitat on the north and the west states of the country but predicted low habitat suitability among inland municipalities of the Caatinga biome reporting rabies. Our findings revealed new areas reporting rabies infecting C. jac-chus, highlighting the need to implement strategies limiting spillover to humans and to better understand the drivers of C. jacchus rabies dynamics.
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spelling Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in BrazilRabies transmitted by wildlife is now the main source of human rabies in the Americas. The common marmoset, Callithrix jacchus, is considered a reservoir of rabies causing sporadic and unpredictable human deaths in Brazil, but the extent of the spillover risk to humans remains unknown. In this study, we described the spatiotemporal dynamics of rabies affect-ing C. jacchus reported to Brazil’s Ministry of Health passive surveillance system between 2008 and 2020, and combined ecological niche modelling with C. jacchus occurrence data to predict its suitable habitat. Our results show that 67 outbreaks (91 cases) of rabies affect-ing C. jacchus were reported by 41 municipalities between January 2008 and October 2020, with a mean of 5 outbreaks/year [range: 1–14]. The maximum number of outbreaks and municipalities reporting cases occurred in 2018, coinciding with higher surveillance of primate deaths due to Yellow Fever. A mean of 3 [1–9] new municipalities reported outbreaks yearly, suggesting potential spatial expansions of the C. jacchus variant in northeastern Brazil and emerging rabies spillover from vampire bat Desmodus rotundus to C. jacchus in the north and south. Outbreaks were concentrated in the states of Ceará (72%) and Pernam-buco (16%) up to 2012, but are now reported in Piauí since 2013, in Bahia since 2017 (D. rotundus’ antigenic variant, AgV3) and in Rio de Janeiro since 2019 (AgV3). Besides confirming suitable habitat for this primate in the northeast and the east coast of Brazil, our Maximum Entropy model also predicted suitable habitat on the north and the west states of the country but predicted low habitat suitability among inland municipalities of the Caatinga biome reporting rabies. Our findings revealed new areas reporting rabies infecting C. jac-chus, highlighting the need to implement strategies limiting spillover to humans and to better understand the drivers of C. jacchus rabies dynamics.Doctorado en Medicina de la Conservación y Centro de Investigación para la Sustentabilidad Facultad de Ciencias de la Vida Universidad Andres Bello, República 440MIVEGEC IRD CNRS Université de MontpellierDepartamento Higiene Veterinária e Saúde Pública Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Júlio de Mesquita FilhoDepartment of Veterinary Pathobiology College of Veterinary Medicine University of MissouriDepartment of Public Health School of Health Professions University of MissouriInstitute of Humanities Arts and Sciences Federal University of Southern Bahia-UFSBSecretaria de Vigilância em Saúde (SVS) Ministério da SaúdeSecretaria de saúde de PernambucoPrograma Estadual de Vigilância de Epizootia Secretaria de saúde de Rio Grande do NorteSetor de Psicobiologia Departamento de Fisiología Universidade Federal do Río Grande do NorteBiodiversity Institute University of KansasInstituto ButantanRetired Researcher Instituto BiológicoDepartamento Higiene Veterinária e Saúde Pública Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Júlio de Mesquita FilhoUniversidad Andres BelloUniversité de MontpellierUniversidade Estadual Paulista (UNESP)University of MissouriUniversidade Federal de Sergipe (UFS)Ministério da SaúdeSecretaria de saúde de PernambucoSecretaria de saúde de Rio Grande do NorteSetor de PsicobiologiaUniversity of KansasInstituto ButantanInstituto BiológicoBenavides, Julio A. [UNESP]Raghavan, Ram K.Boere, VannerRocha, SileneWada, Marcelo Y.Vargas, AlexanderVoietta, FernandaE Silva, Ita de OliveiraLeal, Silvanade Castro, AleneArruda, Maria de FatimaPeterson, A. TownsendMegid, Jane [UNESP]Carrieri, Maria LuizaKotait, Ivanete2022-04-29T08:41:25Z2022-04-29T08:41:25Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pntd.0010254PLoS Neglected Tropical Diseases, v. 16, n. 3, 2022.1935-27351935-2727http://hdl.handle.net/11449/23066210.1371/journal.pntd.00102542-s2.0-85127408615Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/openAccess2022-04-29T08:41:25Zoai:repositorio.unesp.br:11449/230662Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:25.532210Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
title Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
spellingShingle Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
Benavides, Julio A. [UNESP]
title_short Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
title_full Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
title_fullStr Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
title_full_unstemmed Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
title_sort Spatio-temporal dynamics of rabies and habitat suitability of the common marmoset Callithrix jacchus in Brazil
author Benavides, Julio A. [UNESP]
author_facet Benavides, Julio A. [UNESP]
Raghavan, Ram K.
Boere, Vanner
Rocha, Silene
Wada, Marcelo Y.
Vargas, Alexander
Voietta, Fernanda
E Silva, Ita de Oliveira
Leal, Silvana
de Castro, Alene
Arruda, Maria de Fatima
Peterson, A. Townsend
Megid, Jane [UNESP]
Carrieri, Maria Luiza
Kotait, Ivanete
author_role author
author2 Raghavan, Ram K.
Boere, Vanner
Rocha, Silene
Wada, Marcelo Y.
Vargas, Alexander
Voietta, Fernanda
E Silva, Ita de Oliveira
Leal, Silvana
de Castro, Alene
Arruda, Maria de Fatima
Peterson, A. Townsend
Megid, Jane [UNESP]
Carrieri, Maria Luiza
Kotait, Ivanete
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Andres Bello
Université de Montpellier
Universidade Estadual Paulista (UNESP)
University of Missouri
Universidade Federal de Sergipe (UFS)
Ministério da Saúde
Secretaria de saúde de Pernambuco
Secretaria de saúde de Rio Grande do Norte
Setor de Psicobiologia
University of Kansas
Instituto Butantan
Instituto Biológico
dc.contributor.author.fl_str_mv Benavides, Julio A. [UNESP]
Raghavan, Ram K.
Boere, Vanner
Rocha, Silene
Wada, Marcelo Y.
Vargas, Alexander
Voietta, Fernanda
E Silva, Ita de Oliveira
Leal, Silvana
de Castro, Alene
Arruda, Maria de Fatima
Peterson, A. Townsend
Megid, Jane [UNESP]
Carrieri, Maria Luiza
Kotait, Ivanete
description Rabies transmitted by wildlife is now the main source of human rabies in the Americas. The common marmoset, Callithrix jacchus, is considered a reservoir of rabies causing sporadic and unpredictable human deaths in Brazil, but the extent of the spillover risk to humans remains unknown. In this study, we described the spatiotemporal dynamics of rabies affect-ing C. jacchus reported to Brazil’s Ministry of Health passive surveillance system between 2008 and 2020, and combined ecological niche modelling with C. jacchus occurrence data to predict its suitable habitat. Our results show that 67 outbreaks (91 cases) of rabies affect-ing C. jacchus were reported by 41 municipalities between January 2008 and October 2020, with a mean of 5 outbreaks/year [range: 1–14]. The maximum number of outbreaks and municipalities reporting cases occurred in 2018, coinciding with higher surveillance of primate deaths due to Yellow Fever. A mean of 3 [1–9] new municipalities reported outbreaks yearly, suggesting potential spatial expansions of the C. jacchus variant in northeastern Brazil and emerging rabies spillover from vampire bat Desmodus rotundus to C. jacchus in the north and south. Outbreaks were concentrated in the states of Ceará (72%) and Pernam-buco (16%) up to 2012, but are now reported in Piauí since 2013, in Bahia since 2017 (D. rotundus’ antigenic variant, AgV3) and in Rio de Janeiro since 2019 (AgV3). Besides confirming suitable habitat for this primate in the northeast and the east coast of Brazil, our Maximum Entropy model also predicted suitable habitat on the north and the west states of the country but predicted low habitat suitability among inland municipalities of the Caatinga biome reporting rabies. Our findings revealed new areas reporting rabies infecting C. jac-chus, highlighting the need to implement strategies limiting spillover to humans and to better understand the drivers of C. jacchus rabies dynamics.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:41:25Z
2022-04-29T08:41:25Z
2022-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1371/journal.pntd.0010254
PLoS Neglected Tropical Diseases, v. 16, n. 3, 2022.
1935-2735
1935-2727
http://hdl.handle.net/11449/230662
10.1371/journal.pntd.0010254
2-s2.0-85127408615
url http://dx.doi.org/10.1371/journal.pntd.0010254
http://hdl.handle.net/11449/230662
identifier_str_mv PLoS Neglected Tropical Diseases, v. 16, n. 3, 2022.
1935-2735
1935-2727
10.1371/journal.pntd.0010254
2-s2.0-85127408615
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS Neglected Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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