In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold

Detalhes bibliográficos
Autor(a) principal: Minarelli-Gaspar, A. M. [UNESP]
Data de Publicação: 2008
Outros Autores: Saska, S. [UNESP], Jimenez, J., da Cunha, L. R. [UNESP], Bolini, Paulo Domingos André [UNESP], Leal, C., Morejon-Alonso, L., Carrodeguas, R. G., Lopez-Bravo, A., Zavaglia, C. A. C.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scientific.net/KEM.361-363.1127
http://hdl.handle.net/11449/130424
Resumo: The biological behavior of a new bioactive material composed of calcium-deficient hydroxyapatite, octacalcium phosphate, and beta-tricalcium phosphate was investigated by in vitro indirect and direct cytotoxicity, cell adhesion and proliferation tests, and by in vivo subcutaneous and bone implantation in rats. The results of the in vitro studies showed that the material is biocompatible and no cytotoxic. Slightly poorer initial cell adhesion and lower cell proliferation than in control was observed, which were attributed to the reactivity and roughness of the material surface, In vivo results showed that the material is biodegradable and bioactive in bone tissue, but only biocompatible and partially biodegradable in soft tissue.
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spelling In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffoldβ-tricalcium phosphateCalcium deficient hydroxiapatiteIn vitroIn vivoOctacalcium phosphateBioactivityBoneCalcium phosphateCell proliferationCytotoxicityHydroxyapatiteBiomaterialsThe biological behavior of a new bioactive material composed of calcium-deficient hydroxyapatite, octacalcium phosphate, and beta-tricalcium phosphate was investigated by in vitro indirect and direct cytotoxicity, cell adhesion and proliferation tests, and by in vivo subcutaneous and bone implantation in rats. The results of the in vitro studies showed that the material is biocompatible and no cytotoxic. Slightly poorer initial cell adhesion and lower cell proliferation than in control was observed, which were attributed to the reactivity and roughness of the material surface, In vivo results showed that the material is biodegradable and bioactive in bone tissue, but only biocompatible and partially biodegradable in soft tissue.Depto. de Morfologia Fac. de Odontologia de Araraquara UNESP, Rua Humaitá, 1680, 14.801-903 Araraquara-SPUnidad de Investigación Clínica y Biopatología Experimental Hospital Provincial de Ávila, C/ Jesús del Gran Poder, 42, 05003 ÁvilaDepto. de Eng. de Materiais Fac. de Eng. Mecânica UNICAMP, R. Mendeleiev s/n, CP 6122, 13.083-970 Campinas-SPCentro de Biomateriales Universidad de La Habana, Ave. Universidad s/n e/ G y Ronda, 10400 La HabanaDepto. de Morfologia Fac. de Odontologia de Araraquara UNESP, Rua Humaitá, 1680, 14.801-903 Araraquara-SPTrans Tech Publications LtdUniversidade Estadual Paulista (Unesp)Hospital Provincial de ÁvilaUniversidade Estadual de Campinas (UNICAMP)Universidad de La HabanaMinarelli-Gaspar, A. M. [UNESP]Saska, S. [UNESP]Jimenez, J.da Cunha, L. R. [UNESP]Bolini, Paulo Domingos André [UNESP]Leal, C.Morejon-Alonso, L.Carrodeguas, R. G.Lopez-Bravo, A.Zavaglia, C. A. C.2014-05-20T13:46:49Z2014-05-20T13:46:49Z2008-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject1127-1130http://www.scientific.net/KEM.361-363.1127Key Engineering Materials, v. 361-363 II, p. 1127-1130.1013-9826http://hdl.handle.net/11449/13042410.4028/www.scientific.net/KEM.361-363.1127WOS:0002534802002782-s2.0-381491118691393640448238401Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengKey Engineering Materials0,180info:eu-repo/semantics/openAccess2024-09-27T15:15:20Zoai:repositorio.unesp.br:11449/130424Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T15:15:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
title In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
spellingShingle In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
Minarelli-Gaspar, A. M. [UNESP]
β-tricalcium phosphate
Calcium deficient hydroxiapatite
In vitro
In vivo
Octacalcium phosphate
Bioactivity
Bone
Calcium phosphate
Cell proliferation
Cytotoxicity
Hydroxyapatite
Biomaterials
title_short In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
title_full In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
title_fullStr In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
title_full_unstemmed In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
title_sort In vitro and in vivo biological behavior of CDHA/OCP/β-TCP scaffold
author Minarelli-Gaspar, A. M. [UNESP]
author_facet Minarelli-Gaspar, A. M. [UNESP]
Saska, S. [UNESP]
Jimenez, J.
da Cunha, L. R. [UNESP]
Bolini, Paulo Domingos André [UNESP]
Leal, C.
Morejon-Alonso, L.
Carrodeguas, R. G.
Lopez-Bravo, A.
Zavaglia, C. A. C.
author_role author
author2 Saska, S. [UNESP]
Jimenez, J.
da Cunha, L. R. [UNESP]
Bolini, Paulo Domingos André [UNESP]
Leal, C.
Morejon-Alonso, L.
Carrodeguas, R. G.
Lopez-Bravo, A.
Zavaglia, C. A. C.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Hospital Provincial de Ávila
Universidade Estadual de Campinas (UNICAMP)
Universidad de La Habana
dc.contributor.author.fl_str_mv Minarelli-Gaspar, A. M. [UNESP]
Saska, S. [UNESP]
Jimenez, J.
da Cunha, L. R. [UNESP]
Bolini, Paulo Domingos André [UNESP]
Leal, C.
Morejon-Alonso, L.
Carrodeguas, R. G.
Lopez-Bravo, A.
Zavaglia, C. A. C.
dc.subject.por.fl_str_mv β-tricalcium phosphate
Calcium deficient hydroxiapatite
In vitro
In vivo
Octacalcium phosphate
Bioactivity
Bone
Calcium phosphate
Cell proliferation
Cytotoxicity
Hydroxyapatite
Biomaterials
topic β-tricalcium phosphate
Calcium deficient hydroxiapatite
In vitro
In vivo
Octacalcium phosphate
Bioactivity
Bone
Calcium phosphate
Cell proliferation
Cytotoxicity
Hydroxyapatite
Biomaterials
description The biological behavior of a new bioactive material composed of calcium-deficient hydroxyapatite, octacalcium phosphate, and beta-tricalcium phosphate was investigated by in vitro indirect and direct cytotoxicity, cell adhesion and proliferation tests, and by in vivo subcutaneous and bone implantation in rats. The results of the in vitro studies showed that the material is biocompatible and no cytotoxic. Slightly poorer initial cell adhesion and lower cell proliferation than in control was observed, which were attributed to the reactivity and roughness of the material surface, In vivo results showed that the material is biodegradable and bioactive in bone tissue, but only biocompatible and partially biodegradable in soft tissue.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-22
2014-05-20T13:46:49Z
2014-05-20T13:46:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scientific.net/KEM.361-363.1127
Key Engineering Materials, v. 361-363 II, p. 1127-1130.
1013-9826
http://hdl.handle.net/11449/130424
10.4028/www.scientific.net/KEM.361-363.1127
WOS:000253480200278
2-s2.0-38149111869
1393640448238401
url http://www.scientific.net/KEM.361-363.1127
http://hdl.handle.net/11449/130424
identifier_str_mv Key Engineering Materials, v. 361-363 II, p. 1127-1130.
1013-9826
10.4028/www.scientific.net/KEM.361-363.1127
WOS:000253480200278
2-s2.0-38149111869
1393640448238401
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Key Engineering Materials
0,180
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1127-1130
dc.publisher.none.fl_str_mv Trans Tech Publications Ltd
publisher.none.fl_str_mv Trans Tech Publications Ltd
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1813546524004581376

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