Stress-induced subsensitivity to catecholamines depends on the estrous cycle
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1139/y96-050 http://hdl.handle.net/11449/224019 |
Resumo: | In this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stresser agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stresser agent and is strongly influenced by the estrous cycle. |
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Stress-induced subsensitivity to catecholamines depends on the estrous cycleAdrenalineDiestrusEstrusFemale ratsFoot-shock stressNoradrenalineSwimming stressIn this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stresser agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stresser agent and is strongly influenced by the estrous cycle.Depto. de Fisiol. e Biofísica Instituto de Biologia Universidade Estadual de Campinas, Campinas, São PauloDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São PauloBiological Sciences Graduate Program Institute of Biology Universidade Estadual de Campinas, Campinas, São PauloDepto. de Fisiol. e Biofísica Instituto de Biologia UNICAMP, 13081-970, Campinas, São PauloDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São PauloUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Marcondes, F. K.Vanderlei, L. C.M. [UNESP]Lanza, L. L.B.Spadari-Bratfisch, R. C.2022-04-28T19:54:20Z2022-04-28T19:54:20Z1996-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article663-669http://dx.doi.org/10.1139/y96-050Canadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 663-669, 1996.0008-4212http://hdl.handle.net/11449/22401910.1139/y96-0502-s2.0-0029821291Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCanadian Journal of Physiology and Pharmacologyinfo:eu-repo/semantics/openAccess2024-06-18T18:44:02Zoai:repositorio.unesp.br:11449/224019Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:24:34.184106Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
title |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
spellingShingle |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle Marcondes, F. K. Adrenaline Diestrus Estrus Female rats Foot-shock stress Noradrenaline Swimming stress |
title_short |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
title_full |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
title_fullStr |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
title_full_unstemmed |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
title_sort |
Stress-induced subsensitivity to catecholamines depends on the estrous cycle |
author |
Marcondes, F. K. |
author_facet |
Marcondes, F. K. Vanderlei, L. C.M. [UNESP] Lanza, L. L.B. Spadari-Bratfisch, R. C. |
author_role |
author |
author2 |
Vanderlei, L. C.M. [UNESP] Lanza, L. L.B. Spadari-Bratfisch, R. C. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Marcondes, F. K. Vanderlei, L. C.M. [UNESP] Lanza, L. L.B. Spadari-Bratfisch, R. C. |
dc.subject.por.fl_str_mv |
Adrenaline Diestrus Estrus Female rats Foot-shock stress Noradrenaline Swimming stress |
topic |
Adrenaline Diestrus Estrus Female rats Foot-shock stress Noradrenaline Swimming stress |
description |
In this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stresser agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stresser agent and is strongly influenced by the estrous cycle. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-01-01 2022-04-28T19:54:20Z 2022-04-28T19:54:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1139/y96-050 Canadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 663-669, 1996. 0008-4212 http://hdl.handle.net/11449/224019 10.1139/y96-050 2-s2.0-0029821291 |
url |
http://dx.doi.org/10.1139/y96-050 http://hdl.handle.net/11449/224019 |
identifier_str_mv |
Canadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 663-669, 1996. 0008-4212 10.1139/y96-050 2-s2.0-0029821291 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Canadian Journal of Physiology and Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
663-669 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128928832815104 |