Stress-induced subsensitivity to catecholamines depends on the estrous cycle

Detalhes bibliográficos
Autor(a) principal: Marcondes, F. K.
Data de Publicação: 1996
Outros Autores: Vanderlei, L. C.M. [UNESP], Lanza, L. L.B., Spadari-Bratfisch, R. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1139/y96-050
http://hdl.handle.net/11449/224019
Resumo: In this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stresser agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stresser agent and is strongly influenced by the estrous cycle.
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spelling Stress-induced subsensitivity to catecholamines depends on the estrous cycleAdrenalineDiestrusEstrusFemale ratsFoot-shock stressNoradrenalineSwimming stressIn this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stresser agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stresser agent and is strongly influenced by the estrous cycle.Depto. de Fisiol. e Biofísica Instituto de Biologia Universidade Estadual de Campinas, Campinas, São PauloDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São PauloBiological Sciences Graduate Program Institute of Biology Universidade Estadual de Campinas, Campinas, São PauloDepto. de Fisiol. e Biofísica Instituto de Biologia UNICAMP, 13081-970, Campinas, São PauloDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São PauloUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Marcondes, F. K.Vanderlei, L. C.M. [UNESP]Lanza, L. L.B.Spadari-Bratfisch, R. C.2022-04-28T19:54:20Z2022-04-28T19:54:20Z1996-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article663-669http://dx.doi.org/10.1139/y96-050Canadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 663-669, 1996.0008-4212http://hdl.handle.net/11449/22401910.1139/y96-0502-s2.0-0029821291Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCanadian Journal of Physiology and Pharmacologyinfo:eu-repo/semantics/openAccess2024-06-18T18:44:02Zoai:repositorio.unesp.br:11449/224019Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-18T18:44:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Stress-induced subsensitivity to catecholamines depends on the estrous cycle
title Stress-induced subsensitivity to catecholamines depends on the estrous cycle
spellingShingle Stress-induced subsensitivity to catecholamines depends on the estrous cycle
Marcondes, F. K.
Adrenaline
Diestrus
Estrus
Female rats
Foot-shock stress
Noradrenaline
Swimming stress
title_short Stress-induced subsensitivity to catecholamines depends on the estrous cycle
title_full Stress-induced subsensitivity to catecholamines depends on the estrous cycle
title_fullStr Stress-induced subsensitivity to catecholamines depends on the estrous cycle
title_full_unstemmed Stress-induced subsensitivity to catecholamines depends on the estrous cycle
title_sort Stress-induced subsensitivity to catecholamines depends on the estrous cycle
author Marcondes, F. K.
author_facet Marcondes, F. K.
Vanderlei, L. C.M. [UNESP]
Lanza, L. L.B.
Spadari-Bratfisch, R. C.
author_role author
author2 Vanderlei, L. C.M. [UNESP]
Lanza, L. L.B.
Spadari-Bratfisch, R. C.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Marcondes, F. K.
Vanderlei, L. C.M. [UNESP]
Lanza, L. L.B.
Spadari-Bratfisch, R. C.
dc.subject.por.fl_str_mv Adrenaline
Diestrus
Estrus
Female rats
Foot-shock stress
Noradrenaline
Swimming stress
topic Adrenaline
Diestrus
Estrus
Female rats
Foot-shock stress
Noradrenaline
Swimming stress
description In this article we compare how sensitivity to the chronotropic effect of noradrenaline and adrenaline of right atria isolated from female rats is modified after repeated swimming or foot-shock stress, under the influence of the estrous cycle. Right atria from stressed female rats sacrificed at diestrus were subsensitive to both catecholamines, irrespective of the stresser agent. However, although subsensitivity to noradrenaline was of similar intensity, subsensitivity to adrenaline was more pronounced in right atria from foot shock stressed rats as opposed to swimming-stressed rats. Identical stress protocols did not induce any alteration in atrial sensitivity to catecholamines when the stressed female rats were sacrificed at estrus. We conclude that the stress reaction concerning the mediation of cardiac chronotropism by catecholamines is related to the severity of the stresser agent and is strongly influenced by the estrous cycle.
publishDate 1996
dc.date.none.fl_str_mv 1996-01-01
2022-04-28T19:54:20Z
2022-04-28T19:54:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1139/y96-050
Canadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 663-669, 1996.
0008-4212
http://hdl.handle.net/11449/224019
10.1139/y96-050
2-s2.0-0029821291
url http://dx.doi.org/10.1139/y96-050
http://hdl.handle.net/11449/224019
identifier_str_mv Canadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 663-669, 1996.
0008-4212
10.1139/y96-050
2-s2.0-0029821291
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Canadian Journal of Physiology and Pharmacology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 663-669
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1803045368614617088

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