GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS

Detalhes bibliográficos
Autor(a) principal: Rainho, C. A.
Data de Publicação: 1995
Outros Autores: Casartelli, C., Barbierineto, J., Rogatto, Silvia Regina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.gmb.org.br/Revistas/V18/v18a071.pdf
http://hdl.handle.net/11449/34475
Resumo: After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors.
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spelling GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORSAfter in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors.UNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,DEPT GENET,SERV ACONSELHAMENTO GENET,BOTUCATU,SP,BRAZILUNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,DEPT GENET,SERV ACONSELHAMENTO GENET,BOTUCATU,SP,BRAZILSoc Brasil GeneticaUniversidade Estadual Paulista (Unesp)Rainho, C. A.Casartelli, C.Barbierineto, J.Rogatto, Silvia Regina [UNESP]2014-05-20T15:23:46Z2014-05-20T15:23:46Z1995-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article459-467application/pdfhttp://www.gmb.org.br/Revistas/V18/v18a071.pdfRevista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995.0100-8455http://hdl.handle.net/11449/34475WOS:A1995TA98500017WOSA1995TA98500017.pdf88148235451595040000-0002-0285-1162Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Genéticainfo:eu-repo/semantics/openAccess2023-12-03T06:11:30Zoai:repositorio.unesp.br:11449/34475Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-03T06:11:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
title GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
spellingShingle GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
Rainho, C. A.
title_short GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
title_full GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
title_fullStr GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
title_full_unstemmed GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
title_sort GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
author Rainho, C. A.
author_facet Rainho, C. A.
Casartelli, C.
Barbierineto, J.
Rogatto, Silvia Regina [UNESP]
author_role author
author2 Casartelli, C.
Barbierineto, J.
Rogatto, Silvia Regina [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rainho, C. A.
Casartelli, C.
Barbierineto, J.
Rogatto, Silvia Regina [UNESP]
description After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors.
publishDate 1995
dc.date.none.fl_str_mv 1995-09-01
2014-05-20T15:23:46Z
2014-05-20T15:23:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.gmb.org.br/Revistas/V18/v18a071.pdf
Revista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995.
0100-8455
http://hdl.handle.net/11449/34475
WOS:A1995TA98500017
WOSA1995TA98500017.pdf
8814823545159504
0000-0002-0285-1162
url http://www.gmb.org.br/Revistas/V18/v18a071.pdf
http://hdl.handle.net/11449/34475
identifier_str_mv Revista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995.
0100-8455
WOS:A1995TA98500017
WOSA1995TA98500017.pdf
8814823545159504
0000-0002-0285-1162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Genética
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 459-467
application/pdf
dc.publisher.none.fl_str_mv Soc Brasil Genetica
publisher.none.fl_str_mv Soc Brasil Genetica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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