GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.gmb.org.br/Revistas/V18/v18a071.pdf http://hdl.handle.net/11449/34475 |
Resumo: | After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors. |
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GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORSAfter in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors.UNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,DEPT GENET,SERV ACONSELHAMENTO GENET,BOTUCATU,SP,BRAZILUNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,DEPT GENET,SERV ACONSELHAMENTO GENET,BOTUCATU,SP,BRAZILSoc Brasil GeneticaUniversidade Estadual Paulista (Unesp)Rainho, C. A.Casartelli, C.Barbierineto, J.Rogatto, Silvia Regina [UNESP]2014-05-20T15:23:46Z2014-05-20T15:23:46Z1995-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article459-467application/pdfhttp://www.gmb.org.br/Revistas/V18/v18a071.pdfRevista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995.0100-8455http://hdl.handle.net/11449/34475WOS:A1995TA98500017WOSA1995TA98500017.pdf88148235451595040000-0002-0285-1162Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Genéticainfo:eu-repo/semantics/openAccess2023-12-03T06:11:30Zoai:repositorio.unesp.br:11449/34475Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:21:36.848449Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
title |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
spellingShingle |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS Rainho, C. A. |
title_short |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
title_full |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
title_fullStr |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
title_full_unstemmed |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
title_sort |
GENETIC INSTABILITY IN NERVE SHEATH CELL TUMORS |
author |
Rainho, C. A. |
author_facet |
Rainho, C. A. Casartelli, C. Barbierineto, J. Rogatto, Silvia Regina [UNESP] |
author_role |
author |
author2 |
Casartelli, C. Barbierineto, J. Rogatto, Silvia Regina [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Rainho, C. A. Casartelli, C. Barbierineto, J. Rogatto, Silvia Regina [UNESP] |
description |
After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangements were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-09-01 2014-05-20T15:23:46Z 2014-05-20T15:23:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.gmb.org.br/Revistas/V18/v18a071.pdf Revista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995. 0100-8455 http://hdl.handle.net/11449/34475 WOS:A1995TA98500017 WOSA1995TA98500017.pdf 8814823545159504 0000-0002-0285-1162 |
url |
http://www.gmb.org.br/Revistas/V18/v18a071.pdf http://hdl.handle.net/11449/34475 |
identifier_str_mv |
Revista Brasileira de Genetica. Ribeirao Pret: Soc Brasil Genetica, v. 18, n. 3, p. 459-467, 1995. 0100-8455 WOS:A1995TA98500017 WOSA1995TA98500017.pdf 8814823545159504 0000-0002-0285-1162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Genética |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
459-467 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasil Genetica |
publisher.none.fl_str_mv |
Soc Brasil Genetica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129058024718336 |