Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sjournals.com/index.php/SJVA/article/view/1070 http://hdl.handle.net/11449/140552 |
Resumo: | Study rationale: Heparin is routinely administered postoperatively in abdominal surgery to prevent the formation of adhesions; however, there is no consensus in the literature indicating the effectiveness of such use. Objectives: This study sought to assess peritoneal fibrinolytic activity post-enterotomy of the small colon in equines treated with heparin. Methods: In the present study, 10 adult equines were divided into 2 groups of 5 animals each: the control group (CG) and treated group (TG). Both groups underwent laparotomy and enterotomy of the small colon through the right paralumbar fossa in quadrupedal position. In addition, the animals received combinations of flunixin meglumine, gentamicin and penicillin. The TG also received subcutaneous heparin (150 IU/kg, bwt q. 12 hours, 5 days). The animals were evaluated for the peritoneal concentrations of tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and D-dimer at the following time-points: prior to enterotomy (M0); 12 hours after (M1); 1 day after (M2); 2 days after (M3); 4 days after (M4); 6 days after (M5); 10 days after (M6) and 14 days after enterotomy (M7). Results: A significant difference in tPA level was observed between the groups when all time-points were combined, with a median value of 2.59 IU/mL for the CG and 2.03 IU/mL for the TG. Although no significant difference was observed when the groups were compared at different time-points, smaller tPA and D-dimer values were observed for the TG during heparin treatment. Conclusions: In addition to the finding that the TG showed a lower tPA concentration and reduced D-dimer formation, it was concluded that heparin treatment decreased the formation of fibrin clots and peritoneal fibrinolytic activity.Relevance: Because elevated D-dimer levels are directly related to a poor prognosis and high mortality rate, this study reinforced the relevance of the use of heparin in hypercoagulable states and following abdominal surgery. |
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Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparinTissue plasminogen activatorHorseD-dimerFibrinolysisHeparin plasminogen activator inhibitorStudy rationale: Heparin is routinely administered postoperatively in abdominal surgery to prevent the formation of adhesions; however, there is no consensus in the literature indicating the effectiveness of such use. Objectives: This study sought to assess peritoneal fibrinolytic activity post-enterotomy of the small colon in equines treated with heparin. Methods: In the present study, 10 adult equines were divided into 2 groups of 5 animals each: the control group (CG) and treated group (TG). Both groups underwent laparotomy and enterotomy of the small colon through the right paralumbar fossa in quadrupedal position. In addition, the animals received combinations of flunixin meglumine, gentamicin and penicillin. The TG also received subcutaneous heparin (150 IU/kg, bwt q. 12 hours, 5 days). The animals were evaluated for the peritoneal concentrations of tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and D-dimer at the following time-points: prior to enterotomy (M0); 12 hours after (M1); 1 day after (M2); 2 days after (M3); 4 days after (M4); 6 days after (M5); 10 days after (M6) and 14 days after enterotomy (M7). Results: A significant difference in tPA level was observed between the groups when all time-points were combined, with a median value of 2.59 IU/mL for the CG and 2.03 IU/mL for the TG. Although no significant difference was observed when the groups were compared at different time-points, smaller tPA and D-dimer values were observed for the TG during heparin treatment. Conclusions: In addition to the finding that the TG showed a lower tPA concentration and reduced D-dimer formation, it was concluded that heparin treatment decreased the formation of fibrin clots and peritoneal fibrinolytic activity.Relevance: Because elevated D-dimer levels are directly related to a poor prognosis and high mortality rate, this study reinforced the relevance of the use of heparin in hypercoagulable states and following abdominal surgery.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP, BrasilFAPESP: 2011/23359-9Universidade Estadual Paulista (Unesp)Alonso, Juliana de Moura [UNESP]Takahira, Regina Kiomi [UNESP]Bachiega, Tatiana Fernanda [UNESP]Rodrigues, Karoline Alves [UNESP]Yamada, Ana Lúcia Miluzzi [UNESP]Alves, Ana Liz Garcia [UNESP]Watanabe, Marcos Jun [UNESP]Rodrigues, Celso Antônio [UNESP]Hussni, Carlos Alberto [UNESP]2016-07-07T12:34:23Z2016-07-07T12:34:23Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6-13application/pdfhttp://www.sjournals.com/index.php/SJVA/article/view/1070Scientific Journal of Veterinary Advances, v. 3, n. 1, p. 6-13, 2014.2322-1879http://hdl.handle.net/11449/140552ISSN2322-1879-2014-03-01-06-13.pdf466346357546942835178254101788137773733250141398602098493784980179893979513952530000-0003-3323-4199Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Journal of Veterinary Advancesinfo:eu-repo/semantics/openAccess2023-10-27T06:07:11Zoai:repositorio.unesp.br:11449/140552Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:06:08.803878Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
title |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
spellingShingle |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin Alonso, Juliana de Moura [UNESP] Tissue plasminogen activator Horse D-dimer Fibrinolysis Heparin plasminogen activator inhibitor |
title_short |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
title_full |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
title_fullStr |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
title_full_unstemmed |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
title_sort |
Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin |
author |
Alonso, Juliana de Moura [UNESP] |
author_facet |
Alonso, Juliana de Moura [UNESP] Takahira, Regina Kiomi [UNESP] Bachiega, Tatiana Fernanda [UNESP] Rodrigues, Karoline Alves [UNESP] Yamada, Ana Lúcia Miluzzi [UNESP] Alves, Ana Liz Garcia [UNESP] Watanabe, Marcos Jun [UNESP] Rodrigues, Celso Antônio [UNESP] Hussni, Carlos Alberto [UNESP] |
author_role |
author |
author2 |
Takahira, Regina Kiomi [UNESP] Bachiega, Tatiana Fernanda [UNESP] Rodrigues, Karoline Alves [UNESP] Yamada, Ana Lúcia Miluzzi [UNESP] Alves, Ana Liz Garcia [UNESP] Watanabe, Marcos Jun [UNESP] Rodrigues, Celso Antônio [UNESP] Hussni, Carlos Alberto [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alonso, Juliana de Moura [UNESP] Takahira, Regina Kiomi [UNESP] Bachiega, Tatiana Fernanda [UNESP] Rodrigues, Karoline Alves [UNESP] Yamada, Ana Lúcia Miluzzi [UNESP] Alves, Ana Liz Garcia [UNESP] Watanabe, Marcos Jun [UNESP] Rodrigues, Celso Antônio [UNESP] Hussni, Carlos Alberto [UNESP] |
dc.subject.por.fl_str_mv |
Tissue plasminogen activator Horse D-dimer Fibrinolysis Heparin plasminogen activator inhibitor |
topic |
Tissue plasminogen activator Horse D-dimer Fibrinolysis Heparin plasminogen activator inhibitor |
description |
Study rationale: Heparin is routinely administered postoperatively in abdominal surgery to prevent the formation of adhesions; however, there is no consensus in the literature indicating the effectiveness of such use. Objectives: This study sought to assess peritoneal fibrinolytic activity post-enterotomy of the small colon in equines treated with heparin. Methods: In the present study, 10 adult equines were divided into 2 groups of 5 animals each: the control group (CG) and treated group (TG). Both groups underwent laparotomy and enterotomy of the small colon through the right paralumbar fossa in quadrupedal position. In addition, the animals received combinations of flunixin meglumine, gentamicin and penicillin. The TG also received subcutaneous heparin (150 IU/kg, bwt q. 12 hours, 5 days). The animals were evaluated for the peritoneal concentrations of tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and D-dimer at the following time-points: prior to enterotomy (M0); 12 hours after (M1); 1 day after (M2); 2 days after (M3); 4 days after (M4); 6 days after (M5); 10 days after (M6) and 14 days after enterotomy (M7). Results: A significant difference in tPA level was observed between the groups when all time-points were combined, with a median value of 2.59 IU/mL for the CG and 2.03 IU/mL for the TG. Although no significant difference was observed when the groups were compared at different time-points, smaller tPA and D-dimer values were observed for the TG during heparin treatment. Conclusions: In addition to the finding that the TG showed a lower tPA concentration and reduced D-dimer formation, it was concluded that heparin treatment decreased the formation of fibrin clots and peritoneal fibrinolytic activity.Relevance: Because elevated D-dimer levels are directly related to a poor prognosis and high mortality rate, this study reinforced the relevance of the use of heparin in hypercoagulable states and following abdominal surgery. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2016-07-07T12:34:23Z 2016-07-07T12:34:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sjournals.com/index.php/SJVA/article/view/1070 Scientific Journal of Veterinary Advances, v. 3, n. 1, p. 6-13, 2014. 2322-1879 http://hdl.handle.net/11449/140552 ISSN2322-1879-2014-03-01-06-13.pdf 4663463575469428 3517825410178813 7773733250141398 6020984937849801 7989397951395253 0000-0003-3323-4199 |
url |
http://www.sjournals.com/index.php/SJVA/article/view/1070 http://hdl.handle.net/11449/140552 |
identifier_str_mv |
Scientific Journal of Veterinary Advances, v. 3, n. 1, p. 6-13, 2014. 2322-1879 ISSN2322-1879-2014-03-01-06-13.pdf 4663463575469428 3517825410178813 7773733250141398 6020984937849801 7989397951395253 0000-0003-3323-4199 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Journal of Veterinary Advances |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6-13 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128608169885696 |