Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.clnme.2014.02.002 http://hdl.handle.net/11449/167616 |
Resumo: | Background & aim: Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary l-arginine (l-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term of l-arg supplementation and acute resistance exercise (AREX) on the blood lipid profile and inflammatory proteins in overweight men. Methods: Seven overweight men, 46±5yrs, body weight 93.1±12.0Kg and BMI 31.7±3kg/m2, participated in a randomized, double-blind and crossover study, distributed into exercise groups, based on the supplementation (6g/day of placebo or Arginine for 7 days). Supplementation periods were separated by 7-days of wash-out. The AREX was comprised of eight exercises, with an exercise intensity of 60% 1RM. The glucose, lipid profile (NEFA, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol) and inflammatory proteins [plasminogen activator inhibitor-1 (PAI-1) and adiponectin] were determined at rest, immediately, after exercise and 1h after exercise sessions. Results: Triglycerides, total cholesterol, and adiponectin levels not showed time-dependent changes under the different conditions. LDL cholesterol and NEFA levels decreased after 1h recovery periods when compared to rest periods only in l-arg supplementation group (P<0.05). PAI-1 was reduced and HDL cholesterol exhibits increases immediately after AREX and 1h recovery periods when compared with rest periods in both groups (P<0.05). Conclusion: These results indicate that l-arg supplementation can potentiate the effects of exercise inducing changes in the LDL cholesterol and NEFA levels. © 2014 European Society for Clinical Nutrition and Metabolism. |
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Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight menArginine supplementationDyslipidemiaOverweightPlasminogen activator inhibitor-1Resistance exerciseBackground & aim: Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary l-arginine (l-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term of l-arg supplementation and acute resistance exercise (AREX) on the blood lipid profile and inflammatory proteins in overweight men. Methods: Seven overweight men, 46±5yrs, body weight 93.1±12.0Kg and BMI 31.7±3kg/m2, participated in a randomized, double-blind and crossover study, distributed into exercise groups, based on the supplementation (6g/day of placebo or Arginine for 7 days). Supplementation periods were separated by 7-days of wash-out. The AREX was comprised of eight exercises, with an exercise intensity of 60% 1RM. The glucose, lipid profile (NEFA, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol) and inflammatory proteins [plasminogen activator inhibitor-1 (PAI-1) and adiponectin] were determined at rest, immediately, after exercise and 1h after exercise sessions. Results: Triglycerides, total cholesterol, and adiponectin levels not showed time-dependent changes under the different conditions. LDL cholesterol and NEFA levels decreased after 1h recovery periods when compared to rest periods only in l-arg supplementation group (P<0.05). PAI-1 was reduced and HDL cholesterol exhibits increases immediately after AREX and 1h recovery periods when compared with rest periods in both groups (P<0.05). Conclusion: These results indicate that l-arg supplementation can potentiate the effects of exercise inducing changes in the LDL cholesterol and NEFA levels. © 2014 European Society for Clinical Nutrition and Metabolism.Translational Medicine, Universidade Federal de São PauloNephrology Department, Universidade Federal de São PauloCentro de Estudos em Psicobiologia e Exercício (CEPE), Universidade Federal de São PauloPsychobiology Department, Universidade Federal de São PauloPhysiology Department, Universidade Federal de São PauloBioscience Department, Universidade Federal de São PauloFood and Nutrition Department, University of CampinasInternal Medicine Department, University of CampinasLaboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense, SCDepartment of Physical Education, São Paulo State University, UNESP, SPDepartment of Physical Education, São Paulo State University, UNESP, SPUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual de Campinas (UNICAMP)Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul CatarinenseUniversidade Estadual Paulista (Unesp)Nascimento, M. A.Higa, E. M.S.de Mello, M. T.Tufik, S.Oyama, L. M.Santos, R. V.Amaya Farfan, J.Risso, E. M.De Souza, C. T.Pimentel, G. D.Lira, F. S. [UNESP]2018-12-11T16:37:37Z2018-12-11T16:37:37Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.clnme.2014.02.002e-SPEN Journal, v. 9, n. 3, 2014.2212-8263http://hdl.handle.net/11449/16761610.1016/j.clnme.2014.02.0022-s2.0-849014950362-s2.0-84901495036.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPenge-SPEN Journal0,194info:eu-repo/semantics/openAccess2023-10-07T06:06:29Zoai:repositorio.unesp.br:11449/167616Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:15:46.750279Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
title |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
spellingShingle |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men Nascimento, M. A. Arginine supplementation Dyslipidemia Overweight Plasminogen activator inhibitor-1 Resistance exercise |
title_short |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
title_full |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
title_fullStr |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
title_full_unstemmed |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
title_sort |
Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men |
author |
Nascimento, M. A. |
author_facet |
Nascimento, M. A. Higa, E. M.S. de Mello, M. T. Tufik, S. Oyama, L. M. Santos, R. V. Amaya Farfan, J. Risso, E. M. De Souza, C. T. Pimentel, G. D. Lira, F. S. [UNESP] |
author_role |
author |
author2 |
Higa, E. M.S. de Mello, M. T. Tufik, S. Oyama, L. M. Santos, R. V. Amaya Farfan, J. Risso, E. M. De Souza, C. T. Pimentel, G. D. Lira, F. S. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Estadual de Campinas (UNICAMP) Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nascimento, M. A. Higa, E. M.S. de Mello, M. T. Tufik, S. Oyama, L. M. Santos, R. V. Amaya Farfan, J. Risso, E. M. De Souza, C. T. Pimentel, G. D. Lira, F. S. [UNESP] |
dc.subject.por.fl_str_mv |
Arginine supplementation Dyslipidemia Overweight Plasminogen activator inhibitor-1 Resistance exercise |
topic |
Arginine supplementation Dyslipidemia Overweight Plasminogen activator inhibitor-1 Resistance exercise |
description |
Background & aim: Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary l-arginine (l-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term of l-arg supplementation and acute resistance exercise (AREX) on the blood lipid profile and inflammatory proteins in overweight men. Methods: Seven overweight men, 46±5yrs, body weight 93.1±12.0Kg and BMI 31.7±3kg/m2, participated in a randomized, double-blind and crossover study, distributed into exercise groups, based on the supplementation (6g/day of placebo or Arginine for 7 days). Supplementation periods were separated by 7-days of wash-out. The AREX was comprised of eight exercises, with an exercise intensity of 60% 1RM. The glucose, lipid profile (NEFA, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol) and inflammatory proteins [plasminogen activator inhibitor-1 (PAI-1) and adiponectin] were determined at rest, immediately, after exercise and 1h after exercise sessions. Results: Triglycerides, total cholesterol, and adiponectin levels not showed time-dependent changes under the different conditions. LDL cholesterol and NEFA levels decreased after 1h recovery periods when compared to rest periods only in l-arg supplementation group (P<0.05). PAI-1 was reduced and HDL cholesterol exhibits increases immediately after AREX and 1h recovery periods when compared with rest periods in both groups (P<0.05). Conclusion: These results indicate that l-arg supplementation can potentiate the effects of exercise inducing changes in the LDL cholesterol and NEFA levels. © 2014 European Society for Clinical Nutrition and Metabolism. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2018-12-11T16:37:37Z 2018-12-11T16:37:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.clnme.2014.02.002 e-SPEN Journal, v. 9, n. 3, 2014. 2212-8263 http://hdl.handle.net/11449/167616 10.1016/j.clnme.2014.02.002 2-s2.0-84901495036 2-s2.0-84901495036.pdf |
url |
http://dx.doi.org/10.1016/j.clnme.2014.02.002 http://hdl.handle.net/11449/167616 |
identifier_str_mv |
e-SPEN Journal, v. 9, n. 3, 2014. 2212-8263 10.1016/j.clnme.2014.02.002 2-s2.0-84901495036 2-s2.0-84901495036.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
e-SPEN Journal 0,194 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128337347870720 |