Antimicrobial effect of intracanal substances
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-77572007000500015 http://hdl.handle.net/11449/37590 |
Resumo: | In some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Muller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 mu g/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacteria] strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts. |
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Antimicrobial effect of intracanal substancesciprofloxacinmetronidazolepolyethylene glycolsnatrosolendodonticsIn some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Muller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 mu g/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacteria] strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts.Univ São Paulo, Postgrad Program Dent, São Paulo, BrazilUniv Taubate, Dept Dent, Postgrad Program Endodont, Taubate, SP, BrazilSão Paulo State Univ, Sch Dent Sao Jose Campos, Sao Jose Dos Campos, SP, BrazilSão Paulo State Univ, Sch Dent Sao Jose Campos, Sao Jose Dos Campos, SP, BrazilUniversidade de São Paulo (USP), Faculdade de Odontologia de BauruUniversidade de São Paulo (USP)Univ TaubateUniversidade Estadual Paulista (Unesp)Carreira, Claudia de MouraFerreira dos Santos, Silvana SoleoCardoso Jorge, Antonio Olavo [UNESP]Lage-Marques, Jose Luiz2014-05-20T15:27:39Z2014-05-20T15:27:39Z2007-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article453-458application/pdfhttp://dx.doi.org/10.1590/S1678-77572007000500015Journal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 15, n. 5, p. 453-458, 2007.1678-7757http://hdl.handle.net/11449/3759010.1590/S1678-77572007000500015S1678-77572007000500015WOS:000256794600014WOS000256794600014.pdf0053567153623569Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Science1.7090,645info:eu-repo/semantics/openAccess2023-12-11T06:19:41Zoai:repositorio.unesp.br:11449/37590Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-11T06:19:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antimicrobial effect of intracanal substances |
title |
Antimicrobial effect of intracanal substances |
spellingShingle |
Antimicrobial effect of intracanal substances Carreira, Claudia de Moura ciprofloxacin metronidazole polyethylene glycols natrosol endodontics |
title_short |
Antimicrobial effect of intracanal substances |
title_full |
Antimicrobial effect of intracanal substances |
title_fullStr |
Antimicrobial effect of intracanal substances |
title_full_unstemmed |
Antimicrobial effect of intracanal substances |
title_sort |
Antimicrobial effect of intracanal substances |
author |
Carreira, Claudia de Moura |
author_facet |
Carreira, Claudia de Moura Ferreira dos Santos, Silvana Soleo Cardoso Jorge, Antonio Olavo [UNESP] Lage-Marques, Jose Luiz |
author_role |
author |
author2 |
Ferreira dos Santos, Silvana Soleo Cardoso Jorge, Antonio Olavo [UNESP] Lage-Marques, Jose Luiz |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Univ Taubate Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Carreira, Claudia de Moura Ferreira dos Santos, Silvana Soleo Cardoso Jorge, Antonio Olavo [UNESP] Lage-Marques, Jose Luiz |
dc.subject.por.fl_str_mv |
ciprofloxacin metronidazole polyethylene glycols natrosol endodontics |
topic |
ciprofloxacin metronidazole polyethylene glycols natrosol endodontics |
description |
In some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Muller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 mu g/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacteria] strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-09-01 2014-05-20T15:27:39Z 2014-05-20T15:27:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-77572007000500015 Journal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 15, n. 5, p. 453-458, 2007. 1678-7757 http://hdl.handle.net/11449/37590 10.1590/S1678-77572007000500015 S1678-77572007000500015 WOS:000256794600014 WOS000256794600014.pdf 0053567153623569 |
url |
http://dx.doi.org/10.1590/S1678-77572007000500015 http://hdl.handle.net/11449/37590 |
identifier_str_mv |
Journal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 15, n. 5, p. 453-458, 2007. 1678-7757 10.1590/S1678-77572007000500015 S1678-77572007000500015 WOS:000256794600014 WOS000256794600014.pdf 0053567153623569 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Oral Science 1.709 0,645 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
453-458 application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965253262376960 |