Antimicrobial effect of intracanal substances

Detalhes bibliográficos
Autor(a) principal: Carreira, Cláudia de Moura
Data de Publicação: 2007
Outros Autores: Santos, Silvana Soléo Ferreira dos, Jorge, Antônio Olavo Cardoso, Lage-Marques, José Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3510
Resumo: In some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Müller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 µg/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacterial strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts.
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spelling Antimicrobial effect of intracanal substances CiprofloxacinMetronidazolePolyethylene glycolsNatrosolEndodontics In some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Müller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 µg/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacterial strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts. Universidade de São Paulo. Faculdade de Odontologia de Bauru2007-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/351010.1590/S1678-77572007000500015Journal of Applied Oral Science; Vol. 15 No. 5 (2007); 453-458 Journal of Applied Oral Science; Vol. 15 Núm. 5 (2007); 453-458 Journal of Applied Oral Science; v. 15 n. 5 (2007); 453-458 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3510/4200Copyright (c) 2007 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCarreira, Cláudia de MouraSantos, Silvana Soléo Ferreira dosJorge, Antônio Olavo CardosoLage-Marques, José Luiz2012-04-27T11:59:05Zoai:revistas.usp.br:article/3510Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:59:05Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Antimicrobial effect of intracanal substances
title Antimicrobial effect of intracanal substances
spellingShingle Antimicrobial effect of intracanal substances
Carreira, Cláudia de Moura
Ciprofloxacin
Metronidazole
Polyethylene glycols
Natrosol
Endodontics
title_short Antimicrobial effect of intracanal substances
title_full Antimicrobial effect of intracanal substances
title_fullStr Antimicrobial effect of intracanal substances
title_full_unstemmed Antimicrobial effect of intracanal substances
title_sort Antimicrobial effect of intracanal substances
author Carreira, Cláudia de Moura
author_facet Carreira, Cláudia de Moura
Santos, Silvana Soléo Ferreira dos
Jorge, Antônio Olavo Cardoso
Lage-Marques, José Luiz
author_role author
author2 Santos, Silvana Soléo Ferreira dos
Jorge, Antônio Olavo Cardoso
Lage-Marques, José Luiz
author2_role author
author
author
dc.contributor.author.fl_str_mv Carreira, Cláudia de Moura
Santos, Silvana Soléo Ferreira dos
Jorge, Antônio Olavo Cardoso
Lage-Marques, José Luiz
dc.subject.por.fl_str_mv Ciprofloxacin
Metronidazole
Polyethylene glycols
Natrosol
Endodontics
topic Ciprofloxacin
Metronidazole
Polyethylene glycols
Natrosol
Endodontics
description In some situations, endodontic infections do not respond to therapeutic protocol. In these cases, it is suggested the administration of an alternative intracanal medication that presents a wide spectrum of action and has an in-depth effect on the root canal system. The purpose of this study was to assess the antimicrobial action of ciprofloxacin, metronidazole and polyethylene glycol and natrosol vehicles with different associations and concentrations. The minimum inhibitory concentration (MIC) was determined by using the agar dilution method. The culture media (Müller-Hinton agar) were prepared containing antimicrobial agents at multiple two-fold dilutions of 0.25 to 16 µg/mL, and with the vehicles at the concentrations of 50, 45, 40, 35, 30 and 25%. Twenty-three microbial strains were selected for the study. Metronidazole was not capable of eliminating any of the tested microorganisms. The association of ciprofloxacin with metronidazole resulted in a reduction of the MIC. The vehicle polyethylene glycol inhibited the growth of 100% of the tested strains, while natrosol inhibited 18% of the strains. Ciprofloxacin formulations with polyethylene glycol presented better effects than those of formulations to which metronidazole was added. It was possible to conclude that ciprofloxacin presented antimicrobial action against all tested bacterial strains, and its association with metronidazole was synergic. The vehicle polyethylene glycol showed antimicrobial effect and the ciprofloxacin/polyethylene glycol association was the most effective combination for reducing the tested bacteria and yeasts.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3510
10.1590/S1678-77572007000500015
url https://www.revistas.usp.br/jaos/article/view/3510
identifier_str_mv 10.1590/S1678-77572007000500015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3510/4200
dc.rights.driver.fl_str_mv Copyright (c) 2007 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2007 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 15 No. 5 (2007); 453-458
Journal of Applied Oral Science; Vol. 15 Núm. 5 (2007); 453-458
Journal of Applied Oral Science; v. 15 n. 5 (2007); 453-458
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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