Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)

Detalhes bibliográficos
Autor(a) principal: Bernardino, Pedro N. [UNESP]
Data de Publicação: 2019
Outros Autores: Martins, Aline F.A. [UNESP], Barbosa, José D., Schild, Ana L., Damé, Maria Cecília F., Borges, Alexandre S. [UNESP], Oliveira-Filho, José P. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-5150-PVB-6185
http://hdl.handle.net/11449/188988
Resumo: Albinism is a genetic disease characterized by deficient melanin production making affected animals more susceptible to skin problems, negatively influencing production systems of the same. In buffalo, a nonsense mutation (c.1431G>A) in the tyrosinase gene was already described, which is responsible for the oculocutaneous albinism buffalo phenotype. However, prevalence studies have never been performed for this anomaly in Brazil. Therefore, the objective of this study was to investigate this mutation in buffalo herd in Brazil. Of the 315 buffalo tested with no albinism phenotype evident, 11 (3.5%) were heterozygous for the mutation and none were mutated homozygous, showing the existence of the albinism gene in buffalo production herds and proving the importance of prevalence studies for hereditary diseases in order to prevent the dissemination of these same genes and their negative productivity consequences.
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spelling Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)Albinism is a genetic disease characterized by deficient melanin production making affected animals more susceptible to skin problems, negatively influencing production systems of the same. In buffalo, a nonsense mutation (c.1431G>A) in the tyrosinase gene was already described, which is responsible for the oculocutaneous albinism buffalo phenotype. However, prevalence studies have never been performed for this anomaly in Brazil. Therefore, the objective of this study was to investigate this mutation in buffalo herd in Brazil. Of the 315 buffalo tested with no albinism phenotype evident, 11 (3.5%) were heterozygous for the mutation and none were mutated homozygous, showing the existence of the albinism gene in buffalo production herds and proving the importance of prevalence studies for hereditary diseases in order to prevent the dissemination of these same genes and their negative productivity consequences.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (Unesp), Rua Prof. Doutor Walter Mauricio Correas/n, Cx. Postal 560Instituto de Medicina Veterinária Faculdade de Medicina Veterinária Universidade Federal do Pará (UFPA) Campus de Castanhal, Rodovia BR-316 Km 61Laboratório Regional de Diagnóstico Faculdade de Veterinária Universidade Federal de Pelotas, Rua Gomes Carneiro 1Embrapa Clima Temperado Campus Universitário s/nDepartamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (Unesp), Rua Prof. Doutor Walter Mauricio Correas/n, Cx. Postal 560FAPESP: 2015/23569-4CAPES: 432/2014Universidade Estadual Paulista (Unesp)Universidade Federal do Pará (UFPA)Universidade Federal de PelotasEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Bernardino, Pedro N. [UNESP]Martins, Aline F.A. [UNESP]Barbosa, José D.Schild, Ana L.Damé, Maria Cecília F.Borges, Alexandre S. [UNESP]Oliveira-Filho, José P. [UNESP]2019-10-06T16:26:09Z2019-10-06T16:26:09Z2019-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article175-178application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-6185Pesquisa Veterinaria Brasileira, v. 39, n. 3, p. 175-178, 2019.1678-51500100-736Xhttp://hdl.handle.net/11449/18898810.1590/1678-5150-PVB-6185S0100-736X20190003001752-s2.0-85064430934S0100-736X2019000300175.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2024-01-08T06:28:11Zoai:repositorio.unesp.br:11449/188988Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:28:02.896213Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
title Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
spellingShingle Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
Bernardino, Pedro N. [UNESP]
title_short Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
title_full Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
title_fullStr Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
title_full_unstemmed Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
title_sort Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
author Bernardino, Pedro N. [UNESP]
author_facet Bernardino, Pedro N. [UNESP]
Martins, Aline F.A. [UNESP]
Barbosa, José D.
Schild, Ana L.
Damé, Maria Cecília F.
Borges, Alexandre S. [UNESP]
Oliveira-Filho, José P. [UNESP]
author_role author
author2 Martins, Aline F.A. [UNESP]
Barbosa, José D.
Schild, Ana L.
Damé, Maria Cecília F.
Borges, Alexandre S. [UNESP]
Oliveira-Filho, José P. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal do Pará (UFPA)
Universidade Federal de Pelotas
Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.author.fl_str_mv Bernardino, Pedro N. [UNESP]
Martins, Aline F.A. [UNESP]
Barbosa, José D.
Schild, Ana L.
Damé, Maria Cecília F.
Borges, Alexandre S. [UNESP]
Oliveira-Filho, José P. [UNESP]
description Albinism is a genetic disease characterized by deficient melanin production making affected animals more susceptible to skin problems, negatively influencing production systems of the same. In buffalo, a nonsense mutation (c.1431G>A) in the tyrosinase gene was already described, which is responsible for the oculocutaneous albinism buffalo phenotype. However, prevalence studies have never been performed for this anomaly in Brazil. Therefore, the objective of this study was to investigate this mutation in buffalo herd in Brazil. Of the 315 buffalo tested with no albinism phenotype evident, 11 (3.5%) were heterozygous for the mutation and none were mutated homozygous, showing the existence of the albinism gene in buffalo production herds and proving the importance of prevalence studies for hereditary diseases in order to prevent the dissemination of these same genes and their negative productivity consequences.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:26:09Z
2019-10-06T16:26:09Z
2019-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-5150-PVB-6185
Pesquisa Veterinaria Brasileira, v. 39, n. 3, p. 175-178, 2019.
1678-5150
0100-736X
http://hdl.handle.net/11449/188988
10.1590/1678-5150-PVB-6185
S0100-736X2019000300175
2-s2.0-85064430934
S0100-736X2019000300175.pdf
url http://dx.doi.org/10.1590/1678-5150-PVB-6185
http://hdl.handle.net/11449/188988
identifier_str_mv Pesquisa Veterinaria Brasileira, v. 39, n. 3, p. 175-178, 2019.
1678-5150
0100-736X
10.1590/1678-5150-PVB-6185
S0100-736X2019000300175
2-s2.0-85064430934
S0100-736X2019000300175.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 175-178
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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