Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions

Detalhes bibliográficos
Autor(a) principal: da Cunha Valini, Graziela Alves [UNESP]
Data de Publicação: 2023
Outros Autores: Arnaut, Pedro Righetti [UNESP], França, Ismael [UNESP], Ortiz, Manoela Trevisan [UNESP], de Oliveira, Marllon José Karpeggiane [UNESP], Melo, Antonio Diego Brandão [UNESP], Marçal, Danilo Alves [UNESP], Campos, Paulo Henrique Reis Furtado, Htoo, John Khun, Brand, Henrique Gastmann, Hauschild, Luciano [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/jas/skad141
http://hdl.handle.net/11449/248865
Resumo: Highly intensified rearing conditions and precarious sanitary management predispose pigs to immune system activation, altered amino acid (AA) metabolism, and decreased growth performance. Thus, the main objective of this study was to evaluate the effects of increased dietary tryptophan (Trp), threonine (Thr), and methionine + cysteine (Met + Cys) supplementation on performance, body composition, metabolism, and immune responses of group-housed growing pigs under challenging sanitary conditions. A hundred and twenty pigs (25.4 ± 3.7 kg) were randomly assigned to a 2 × 2 factorial arrangement, consisting of two sanitary conditions (SC, good [GOOD] or salmonella-challenge and poor housing condition [Salmonella Typhimurium (ST) + POOR]) and two diets, control (CN) or supplemented with AA (Trp, Thr, and Met + Cys:Lys ratios 20% higher than those of the CN diet [AA>+]). Pigs were followed during the growing phase (25-50 kg) and the trial lasted 28 d. The ST + POOR SC pigs were challenged with Salmonella Typhimurium and raised in a poor housing condition. The ST + POOR SC increased rectal temperature, fecal score, serum haptoglobin, and urea concentration (P < 0.05) and decreased serum albumin concentration (P < 0.05) compared with GOOD SC. Body weight, average daily feed intake, average daily gain (ADG), feed efficiency (G:F), and protein deposition (PD) were greater in GOOD SC than in ST + POOR SC (P < 0.01). However, pigs housed in ST + POOR SC fed with AA+ diet had lower body temperature (P < 0.05), increased ADG (P < 0.05) and nitrogen efficiency (P < 0.05), and a tendency for improved PD and G:F (P < 0.10) compared with CN diet fed pigs. Regardless of the SC, pigs fed AA+ diet had lower serum albumin (P < 0.05) and tended to decrease serum urea levels (P < 0.10) compared with CN diet. The results of this study suggest that the ratio of Trp, Thr, and Met + Cys to Lys for pigs are modified by sanitary conditions. Furthermore, supplementation of diets with a blend of Trp, Thr, and Met + Cys improves performance, especially under salmonella-challenge and poor housing conditions. Dietary tryptophan, threonine, and methionine supplementation can modulate immune status and influence resilience to sanitary challenges.
id UNSP_c062fc2a9415e1ad2975366320ccad4f
oai_identifier_str oai:repositorio.unesp.br:11449/248865
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditionsamino acidsbody compositionimmune systeminflammationswineHighly intensified rearing conditions and precarious sanitary management predispose pigs to immune system activation, altered amino acid (AA) metabolism, and decreased growth performance. Thus, the main objective of this study was to evaluate the effects of increased dietary tryptophan (Trp), threonine (Thr), and methionine + cysteine (Met + Cys) supplementation on performance, body composition, metabolism, and immune responses of group-housed growing pigs under challenging sanitary conditions. A hundred and twenty pigs (25.4 ± 3.7 kg) were randomly assigned to a 2 × 2 factorial arrangement, consisting of two sanitary conditions (SC, good [GOOD] or salmonella-challenge and poor housing condition [Salmonella Typhimurium (ST) + POOR]) and two diets, control (CN) or supplemented with AA (Trp, Thr, and Met + Cys:Lys ratios 20% higher than those of the CN diet [AA>+]). Pigs were followed during the growing phase (25-50 kg) and the trial lasted 28 d. The ST + POOR SC pigs were challenged with Salmonella Typhimurium and raised in a poor housing condition. The ST + POOR SC increased rectal temperature, fecal score, serum haptoglobin, and urea concentration (P < 0.05) and decreased serum albumin concentration (P < 0.05) compared with GOOD SC. Body weight, average daily feed intake, average daily gain (ADG), feed efficiency (G:F), and protein deposition (PD) were greater in GOOD SC than in ST + POOR SC (P < 0.01). However, pigs housed in ST + POOR SC fed with AA+ diet had lower body temperature (P < 0.05), increased ADG (P < 0.05) and nitrogen efficiency (P < 0.05), and a tendency for improved PD and G:F (P < 0.10) compared with CN diet fed pigs. Regardless of the SC, pigs fed AA+ diet had lower serum albumin (P < 0.05) and tended to decrease serum urea levels (P < 0.10) compared with CN diet. The results of this study suggest that the ratio of Trp, Thr, and Met + Cys to Lys for pigs are modified by sanitary conditions. Furthermore, supplementation of diets with a blend of Trp, Thr, and Met + Cys improves performance, especially under salmonella-challenge and poor housing conditions. Dietary tryptophan, threonine, and methionine supplementation can modulate immune status and influence resilience to sanitary challenges.Department of Animal Science Agriculture and Veterinarian Sciences Universidade Estadual Paulista Júlio de Mesquita Filho, JaboticabalDepartment of Animal Science Universidade Federal de Viçosa, Minas GeraisEvonik Operations GmbHEvonik Brasil Ltda.Department of Animal Science Agriculture and Veterinarian Sciences Universidade Estadual Paulista Júlio de Mesquita Filho, JaboticabalUniversidade Estadual Paulista (UNESP)Universidade Federal de Viçosa (UFV)Evonik Operations GmbHEvonik Brasil Ltda.da Cunha Valini, Graziela Alves [UNESP]Arnaut, Pedro Righetti [UNESP]França, Ismael [UNESP]Ortiz, Manoela Trevisan [UNESP]de Oliveira, Marllon José Karpeggiane [UNESP]Melo, Antonio Diego Brandão [UNESP]Marçal, Danilo Alves [UNESP]Campos, Paulo Henrique Reis FurtadoHtoo, John KhunBrand, Henrique GastmannHauschild, Luciano [UNESP]2023-07-29T13:55:52Z2023-07-29T13:55:52Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/jas/skad141Journal of Animal Science, v. 101.1525-31630021-8812http://hdl.handle.net/11449/24886510.1093/jas/skad1412-s2.0-85160005016Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Animal Scienceinfo:eu-repo/semantics/openAccess2024-06-07T18:41:17Zoai:repositorio.unesp.br:11449/248865Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:12:16.387994Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
title Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
spellingShingle Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
da Cunha Valini, Graziela Alves [UNESP]
amino acids
body composition
immune system
inflammation
swine
title_short Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
title_full Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
title_fullStr Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
title_full_unstemmed Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
title_sort Increased dietary Trp, Thr, and Met supplementation improves growth performance and protein deposition of salmonella-challenged growing pigs under poor housing conditions
author da Cunha Valini, Graziela Alves [UNESP]
author_facet da Cunha Valini, Graziela Alves [UNESP]
Arnaut, Pedro Righetti [UNESP]
França, Ismael [UNESP]
Ortiz, Manoela Trevisan [UNESP]
de Oliveira, Marllon José Karpeggiane [UNESP]
Melo, Antonio Diego Brandão [UNESP]
Marçal, Danilo Alves [UNESP]
Campos, Paulo Henrique Reis Furtado
Htoo, John Khun
Brand, Henrique Gastmann
Hauschild, Luciano [UNESP]
author_role author
author2 Arnaut, Pedro Righetti [UNESP]
França, Ismael [UNESP]
Ortiz, Manoela Trevisan [UNESP]
de Oliveira, Marllon José Karpeggiane [UNESP]
Melo, Antonio Diego Brandão [UNESP]
Marçal, Danilo Alves [UNESP]
Campos, Paulo Henrique Reis Furtado
Htoo, John Khun
Brand, Henrique Gastmann
Hauschild, Luciano [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Federal de Viçosa (UFV)
Evonik Operations GmbH
Evonik Brasil Ltda.
dc.contributor.author.fl_str_mv da Cunha Valini, Graziela Alves [UNESP]
Arnaut, Pedro Righetti [UNESP]
França, Ismael [UNESP]
Ortiz, Manoela Trevisan [UNESP]
de Oliveira, Marllon José Karpeggiane [UNESP]
Melo, Antonio Diego Brandão [UNESP]
Marçal, Danilo Alves [UNESP]
Campos, Paulo Henrique Reis Furtado
Htoo, John Khun
Brand, Henrique Gastmann
Hauschild, Luciano [UNESP]
dc.subject.por.fl_str_mv amino acids
body composition
immune system
inflammation
swine
topic amino acids
body composition
immune system
inflammation
swine
description Highly intensified rearing conditions and precarious sanitary management predispose pigs to immune system activation, altered amino acid (AA) metabolism, and decreased growth performance. Thus, the main objective of this study was to evaluate the effects of increased dietary tryptophan (Trp), threonine (Thr), and methionine + cysteine (Met + Cys) supplementation on performance, body composition, metabolism, and immune responses of group-housed growing pigs under challenging sanitary conditions. A hundred and twenty pigs (25.4 ± 3.7 kg) were randomly assigned to a 2 × 2 factorial arrangement, consisting of two sanitary conditions (SC, good [GOOD] or salmonella-challenge and poor housing condition [Salmonella Typhimurium (ST) + POOR]) and two diets, control (CN) or supplemented with AA (Trp, Thr, and Met + Cys:Lys ratios 20% higher than those of the CN diet [AA>+]). Pigs were followed during the growing phase (25-50 kg) and the trial lasted 28 d. The ST + POOR SC pigs were challenged with Salmonella Typhimurium and raised in a poor housing condition. The ST + POOR SC increased rectal temperature, fecal score, serum haptoglobin, and urea concentration (P < 0.05) and decreased serum albumin concentration (P < 0.05) compared with GOOD SC. Body weight, average daily feed intake, average daily gain (ADG), feed efficiency (G:F), and protein deposition (PD) were greater in GOOD SC than in ST + POOR SC (P < 0.01). However, pigs housed in ST + POOR SC fed with AA+ diet had lower body temperature (P < 0.05), increased ADG (P < 0.05) and nitrogen efficiency (P < 0.05), and a tendency for improved PD and G:F (P < 0.10) compared with CN diet fed pigs. Regardless of the SC, pigs fed AA+ diet had lower serum albumin (P < 0.05) and tended to decrease serum urea levels (P < 0.10) compared with CN diet. The results of this study suggest that the ratio of Trp, Thr, and Met + Cys to Lys for pigs are modified by sanitary conditions. Furthermore, supplementation of diets with a blend of Trp, Thr, and Met + Cys improves performance, especially under salmonella-challenge and poor housing conditions. Dietary tryptophan, threonine, and methionine supplementation can modulate immune status and influence resilience to sanitary challenges.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T13:55:52Z
2023-07-29T13:55:52Z
2023-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/jas/skad141
Journal of Animal Science, v. 101.
1525-3163
0021-8812
http://hdl.handle.net/11449/248865
10.1093/jas/skad141
2-s2.0-85160005016
url http://dx.doi.org/10.1093/jas/skad141
http://hdl.handle.net/11449/248865
identifier_str_mv Journal of Animal Science, v. 101.
1525-3163
0021-8812
10.1093/jas/skad141
2-s2.0-85160005016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Animal Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128771314679808