Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4238/gmr18661 http://hdl.handle.net/11449/209218 |
Resumo: | Annona sylvatica (Annonaceae) is a common medicinal plant used in folk medicine for fever and cough; it is found in several Brazilian states, including Mato Grosso do Sul. The local population uses A. sylvatica leaves for treating fever and cough; however, how this medicinal plant affects the patients is little understood. We evaluated the anti- inflammatory and anti-allergic properties of a methanolic extract of A. sylvatica (MEAS) leaves in mouse models of inflammation and allergy. The study employed male C57bL/6 mice for allergy models and male Swiss mice for the inflammation study. Oral treatments with MEAS (30 to 150 mg/kg) significantly inhibited the carrageenan- induced leukocyte migration and protein extravasation to the cavity in an air pouch model. In the allergic animal models, oral treatment with MEAS (150 mg/kg) significantly reduced histamine- and ovalbumin (OVA)-induced paw edema. Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung. Pretreatment of neutrophils with MEAS (3, 150, 300 mu g/mL) significantly reduced neutrophil chemotaxis induced by NFormyl-Met-Leu- Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner. We conclude that A. sylvatica has antiinflammatory and anti-allergic properties. Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects. |
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Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)AraticumAllergyInflammationOvalbuminAir pouchHistamineAnnona sylvatica (Annonaceae) is a common medicinal plant used in folk medicine for fever and cough; it is found in several Brazilian states, including Mato Grosso do Sul. The local population uses A. sylvatica leaves for treating fever and cough; however, how this medicinal plant affects the patients is little understood. We evaluated the anti- inflammatory and anti-allergic properties of a methanolic extract of A. sylvatica (MEAS) leaves in mouse models of inflammation and allergy. The study employed male C57bL/6 mice for allergy models and male Swiss mice for the inflammation study. Oral treatments with MEAS (30 to 150 mg/kg) significantly inhibited the carrageenan- induced leukocyte migration and protein extravasation to the cavity in an air pouch model. In the allergic animal models, oral treatment with MEAS (150 mg/kg) significantly reduced histamine- and ovalbumin (OVA)-induced paw edema. Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung. Pretreatment of neutrophils with MEAS (3, 150, 300 mu g/mL) significantly reduced neutrophil chemotaxis induced by NFormyl-Met-Leu- Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner. We conclude that A. sylvatica has antiinflammatory and anti-allergic properties. Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FUNDECTConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Dourados, MS, BrazilFundacao Oswaldo Cruz, Farmanguinhos, Lab Farmacol Aplicada, Rio De Janeiro, RJ, BrazilFundacao Univ Fed Grande Dourados, Fac Ciencias Agr, Dourados, MS, BrazilUniv Sao Paulo, Fac Med, Dept Reumatol, Sao Paulo, SP, BrazilUniv Nove Julho, Sao Paulo, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Biol Estrutural & Func, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Biol Estrutural & Func, Botucatu, SP, BrazilFunpec-editoraFundacao Univ Fed Grande DouradosFundacao Oswaldo CruzUniversidade de São Paulo (USP)Univ Nove JulhoUniversidade Estadual Paulista (Unesp)Andrade-Silva, M.Cavalher-Machado, S. C.Formagio, A. S. N.Maris, R. S.Lima Junior, O. M. deMello, S. B. deHenriques, M. G. M. O.Arena, A. C. [UNESP]Kassuya, C. A. L.2021-06-25T11:51:51Z2021-06-25T11:51:51Z2020-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.4238/gmr18661Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 19, n. 3, 12 p., 2020.http://hdl.handle.net/11449/20921810.4238/gmr18661WOS:000619543900001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics And Molecular Researchinfo:eu-repo/semantics/openAccess2021-10-23T19:23:38Zoai:repositorio.unesp.br:11449/209218Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:05:20.568451Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
title |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
spellingShingle |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) Andrade-Silva, M. Araticum Allergy Inflammation Ovalbumin Air pouch Histamine |
title_short |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
title_full |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
title_fullStr |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
title_full_unstemmed |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
title_sort |
Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae) |
author |
Andrade-Silva, M. |
author_facet |
Andrade-Silva, M. Cavalher-Machado, S. C. Formagio, A. S. N. Maris, R. S. Lima Junior, O. M. de Mello, S. B. de Henriques, M. G. M. O. Arena, A. C. [UNESP] Kassuya, C. A. L. |
author_role |
author |
author2 |
Cavalher-Machado, S. C. Formagio, A. S. N. Maris, R. S. Lima Junior, O. M. de Mello, S. B. de Henriques, M. G. M. O. Arena, A. C. [UNESP] Kassuya, C. A. L. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Fundacao Univ Fed Grande Dourados Fundacao Oswaldo Cruz Universidade de São Paulo (USP) Univ Nove Julho Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Andrade-Silva, M. Cavalher-Machado, S. C. Formagio, A. S. N. Maris, R. S. Lima Junior, O. M. de Mello, S. B. de Henriques, M. G. M. O. Arena, A. C. [UNESP] Kassuya, C. A. L. |
dc.subject.por.fl_str_mv |
Araticum Allergy Inflammation Ovalbumin Air pouch Histamine |
topic |
Araticum Allergy Inflammation Ovalbumin Air pouch Histamine |
description |
Annona sylvatica (Annonaceae) is a common medicinal plant used in folk medicine for fever and cough; it is found in several Brazilian states, including Mato Grosso do Sul. The local population uses A. sylvatica leaves for treating fever and cough; however, how this medicinal plant affects the patients is little understood. We evaluated the anti- inflammatory and anti-allergic properties of a methanolic extract of A. sylvatica (MEAS) leaves in mouse models of inflammation and allergy. The study employed male C57bL/6 mice for allergy models and male Swiss mice for the inflammation study. Oral treatments with MEAS (30 to 150 mg/kg) significantly inhibited the carrageenan- induced leukocyte migration and protein extravasation to the cavity in an air pouch model. In the allergic animal models, oral treatment with MEAS (150 mg/kg) significantly reduced histamine- and ovalbumin (OVA)-induced paw edema. Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung. Pretreatment of neutrophils with MEAS (3, 150, 300 mu g/mL) significantly reduced neutrophil chemotaxis induced by NFormyl-Met-Leu- Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner. We conclude that A. sylvatica has antiinflammatory and anti-allergic properties. Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-30 2021-06-25T11:51:51Z 2021-06-25T11:51:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4238/gmr18661 Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 19, n. 3, 12 p., 2020. http://hdl.handle.net/11449/209218 10.4238/gmr18661 WOS:000619543900001 |
url |
http://dx.doi.org/10.4238/gmr18661 http://hdl.handle.net/11449/209218 |
identifier_str_mv |
Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 19, n. 3, 12 p., 2020. 10.4238/gmr18661 WOS:000619543900001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics And Molecular Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 |
dc.publisher.none.fl_str_mv |
Funpec-editora |
publisher.none.fl_str_mv |
Funpec-editora |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128753865326592 |