Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)

Detalhes bibliográficos
Autor(a) principal: Andrade-Silva, M.
Data de Publicação: 2020
Outros Autores: Cavalher-Machado, S. C., Formagio, A. S. N., Maris, R. S., Lima Junior, O. M. de, Mello, S. B. de, Henriques, M. G. M. O., Arena, A. C. [UNESP], Kassuya, C. A. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4238/gmr18661
http://hdl.handle.net/11449/209218
Resumo: Annona sylvatica (Annonaceae) is a common medicinal plant used in folk medicine for fever and cough; it is found in several Brazilian states, including Mato Grosso do Sul. The local population uses A. sylvatica leaves for treating fever and cough; however, how this medicinal plant affects the patients is little understood. We evaluated the anti- inflammatory and anti-allergic properties of a methanolic extract of A. sylvatica (MEAS) leaves in mouse models of inflammation and allergy. The study employed male C57bL/6 mice for allergy models and male Swiss mice for the inflammation study. Oral treatments with MEAS (30 to 150 mg/kg) significantly inhibited the carrageenan- induced leukocyte migration and protein extravasation to the cavity in an air pouch model. In the allergic animal models, oral treatment with MEAS (150 mg/kg) significantly reduced histamine- and ovalbumin (OVA)-induced paw edema. Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung. Pretreatment of neutrophils with MEAS (3, 150, 300 mu g/mL) significantly reduced neutrophil chemotaxis induced by NFormyl-Met-Leu- Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner. We conclude that A. sylvatica has antiinflammatory and anti-allergic properties. Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects.
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spelling Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)AraticumAllergyInflammationOvalbuminAir pouchHistamineAnnona sylvatica (Annonaceae) is a common medicinal plant used in folk medicine for fever and cough; it is found in several Brazilian states, including Mato Grosso do Sul. The local population uses A. sylvatica leaves for treating fever and cough; however, how this medicinal plant affects the patients is little understood. We evaluated the anti- inflammatory and anti-allergic properties of a methanolic extract of A. sylvatica (MEAS) leaves in mouse models of inflammation and allergy. The study employed male C57bL/6 mice for allergy models and male Swiss mice for the inflammation study. Oral treatments with MEAS (30 to 150 mg/kg) significantly inhibited the carrageenan- induced leukocyte migration and protein extravasation to the cavity in an air pouch model. In the allergic animal models, oral treatment with MEAS (150 mg/kg) significantly reduced histamine- and ovalbumin (OVA)-induced paw edema. Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung. Pretreatment of neutrophils with MEAS (3, 150, 300 mu g/mL) significantly reduced neutrophil chemotaxis induced by NFormyl-Met-Leu- Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner. We conclude that A. sylvatica has antiinflammatory and anti-allergic properties. Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FUNDECTConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Dourados, MS, BrazilFundacao Oswaldo Cruz, Farmanguinhos, Lab Farmacol Aplicada, Rio De Janeiro, RJ, BrazilFundacao Univ Fed Grande Dourados, Fac Ciencias Agr, Dourados, MS, BrazilUniv Sao Paulo, Fac Med, Dept Reumatol, Sao Paulo, SP, BrazilUniv Nove Julho, Sao Paulo, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Biol Estrutural & Func, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Biol Estrutural & Func, Botucatu, SP, BrazilFunpec-editoraFundacao Univ Fed Grande DouradosFundacao Oswaldo CruzUniversidade de São Paulo (USP)Univ Nove JulhoUniversidade Estadual Paulista (Unesp)Andrade-Silva, M.Cavalher-Machado, S. C.Formagio, A. S. N.Maris, R. S.Lima Junior, O. M. deMello, S. B. deHenriques, M. G. M. O.Arena, A. C. [UNESP]Kassuya, C. A. L.2021-06-25T11:51:51Z2021-06-25T11:51:51Z2020-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.4238/gmr18661Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 19, n. 3, 12 p., 2020.http://hdl.handle.net/11449/20921810.4238/gmr18661WOS:000619543900001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics And Molecular Researchinfo:eu-repo/semantics/openAccess2021-10-23T19:23:38Zoai:repositorio.unesp.br:11449/209218Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:05:20.568451Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
title Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
spellingShingle Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
Andrade-Silva, M.
Araticum
Allergy
Inflammation
Ovalbumin
Air pouch
Histamine
title_short Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
title_full Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
title_fullStr Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
title_full_unstemmed Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
title_sort Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)
author Andrade-Silva, M.
author_facet Andrade-Silva, M.
Cavalher-Machado, S. C.
Formagio, A. S. N.
Maris, R. S.
Lima Junior, O. M. de
Mello, S. B. de
Henriques, M. G. M. O.
Arena, A. C. [UNESP]
Kassuya, C. A. L.
author_role author
author2 Cavalher-Machado, S. C.
Formagio, A. S. N.
Maris, R. S.
Lima Junior, O. M. de
Mello, S. B. de
Henriques, M. G. M. O.
Arena, A. C. [UNESP]
Kassuya, C. A. L.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundacao Univ Fed Grande Dourados
Fundacao Oswaldo Cruz
Universidade de São Paulo (USP)
Univ Nove Julho
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Andrade-Silva, M.
Cavalher-Machado, S. C.
Formagio, A. S. N.
Maris, R. S.
Lima Junior, O. M. de
Mello, S. B. de
Henriques, M. G. M. O.
Arena, A. C. [UNESP]
Kassuya, C. A. L.
dc.subject.por.fl_str_mv Araticum
Allergy
Inflammation
Ovalbumin
Air pouch
Histamine
topic Araticum
Allergy
Inflammation
Ovalbumin
Air pouch
Histamine
description Annona sylvatica (Annonaceae) is a common medicinal plant used in folk medicine for fever and cough; it is found in several Brazilian states, including Mato Grosso do Sul. The local population uses A. sylvatica leaves for treating fever and cough; however, how this medicinal plant affects the patients is little understood. We evaluated the anti- inflammatory and anti-allergic properties of a methanolic extract of A. sylvatica (MEAS) leaves in mouse models of inflammation and allergy. The study employed male C57bL/6 mice for allergy models and male Swiss mice for the inflammation study. Oral treatments with MEAS (30 to 150 mg/kg) significantly inhibited the carrageenan- induced leukocyte migration and protein extravasation to the cavity in an air pouch model. In the allergic animal models, oral treatment with MEAS (150 mg/kg) significantly reduced histamine- and ovalbumin (OVA)-induced paw edema. Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung. Pretreatment of neutrophils with MEAS (3, 150, 300 mu g/mL) significantly reduced neutrophil chemotaxis induced by NFormyl-Met-Leu- Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner. We conclude that A. sylvatica has antiinflammatory and anti-allergic properties. Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-30
2021-06-25T11:51:51Z
2021-06-25T11:51:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4238/gmr18661
Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 19, n. 3, 12 p., 2020.
http://hdl.handle.net/11449/209218
10.4238/gmr18661
WOS:000619543900001
url http://dx.doi.org/10.4238/gmr18661
http://hdl.handle.net/11449/209218
identifier_str_mv Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 19, n. 3, 12 p., 2020.
10.4238/gmr18661
WOS:000619543900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics And Molecular Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
dc.publisher.none.fl_str_mv Funpec-editora
publisher.none.fl_str_mv Funpec-editora
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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