Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice

Detalhes bibliográficos
Autor(a) principal: Medeiros, K. C. P.
Data de Publicação: 2008
Outros Autores: Figueiredo, C. A. V., Figueredo, T. B., Freire, K. R. L., Santos, F. A. R., Alcântara-Neves, Neuza Maria, Silva, T. M. S., Piuvezam, M. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6043
Resumo: Acesso restrito: Texto completo. p. 41-46.
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spelling Medeiros, K. C. P.Figueiredo, C. A. V.Figueredo, T. B.Freire, K. R. L.Santos, F. A. R.Alcântara-Neves, Neuza MariaSilva, T. M. S.Piuvezam, M. R.Medeiros, K. C. P.Figueiredo, C. A. V.Figueredo, T. B.Freire, K. R. L.Santos, F. A. R.Alcântara-Neves, Neuza MariaSilva, T. M. S.Piuvezam, M. R.2012-06-01T13:08:51Z20080378-8741http://www.repositorio.ufba.br/ri/handle/ri/6043v. 119, n. 1Acesso restrito: Texto completo. p. 41-46.Ethnopharmacological relevance: The bee pollen is used in folk medicine to alleviate allergic reactions. The bee pollen phenolic extract (BPPE) consists in phenolic compounds (flavonoids) from plants picked by Apis mellifera bee. Aim of this study: Here we evaluated the anti-allergic property of the BPPE and the flavonoid myricetin (MYR) in murine model of ovalbumin (OVA)-induced allergy. Materials and methods: The study focused on the BPPE or myricetin treatment of OVA-sensitized BALB/c mice and their effects on the IgE and IgG1 production, pulmonary cell migration, eosinophil peroxidase (EPO) activity and anaphylactic shock reaction. Results: The BPPE treatment (200 mg/kg) showed inhibition of the paw edema, IgE and IgG1 OVA-specific production, leukocyte migration to the bronchoalveolar lavage (BAL) and EPO activity in lungs. In addition, BPPE treatment showed partial protection on the anaphylactic shock reaction induced by OVA. Treatment with myricetin (5 mg/kg) also inhibited pulmonary cell migration and IgE and IgG1 OVA-specific production. Conclusions: These results support the hypothesis themyricetin is one of the flavonoids of BPPE responsible for the anti-allergic effect and a potential tool to treat allergies.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-06-01T13:08:51Z No. of bitstreams: 1 __ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf: 278587 bytes, checksum: 1d969b03486fb42281cce4979dece7b2 (MD5)Made available in DSpace on 2012-06-01T13:08:51Z (GMT). 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dc.title.pt_BR.fl_str_mv Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
dc.title.alternative.pt_BR.fl_str_mv Journal of Ethnopharmacology
title Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
spellingShingle Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
Medeiros, K. C. P.
Bee pollen phenolic extract
Myricetin
Flavonoid
Allergy
Ovalbumin
title_short Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_full Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_fullStr Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_full_unstemmed Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_sort Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
author Medeiros, K. C. P.
author_facet Medeiros, K. C. P.
Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
author_role author
author2 Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Medeiros, K. C. P.
Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
Medeiros, K. C. P.
Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
dc.subject.por.fl_str_mv Bee pollen phenolic extract
Myricetin
Flavonoid
Allergy
Ovalbumin
topic Bee pollen phenolic extract
Myricetin
Flavonoid
Allergy
Ovalbumin
description Acesso restrito: Texto completo. p. 41-46.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-06-01T13:08:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6043
dc.identifier.issn.none.fl_str_mv 0378-8741
dc.identifier.number.pt_BR.fl_str_mv v. 119, n. 1
identifier_str_mv 0378-8741
v. 119, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6043
dc.language.iso.fl_str_mv eng
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