Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice

Detalhes bibliográficos
Autor(a) principal: Medeiros, K. C. P.
Data de Publicação: 2008
Outros Autores: Figueiredo, C. A. V., Figueredo, T. B., Freire, K. R. L., Santos, F. A. R., Alcântara-Neves, Neuza Maria, Silva, T. M. S., Piuvezam, M. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6043
Resumo: Acesso restrito: Texto completo. p. 41-46.
id UFBA-2_4eb03162f6fdd00db5c589917736182c
oai_identifier_str oai:repositorio.ufba.br:ri/6043
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Medeiros, K. C. P.Figueiredo, C. A. V.Figueredo, T. B.Freire, K. R. L.Santos, F. A. R.Alcântara-Neves, Neuza MariaSilva, T. M. S.Piuvezam, M. R.Medeiros, K. C. P.Figueiredo, C. A. V.Figueredo, T. B.Freire, K. R. L.Santos, F. A. R.Alcântara-Neves, Neuza MariaSilva, T. M. S.Piuvezam, M. R.2012-06-01T13:08:51Z20080378-8741http://www.repositorio.ufba.br/ri/handle/ri/6043v. 119, n. 1Acesso restrito: Texto completo. p. 41-46.Ethnopharmacological relevance: The bee pollen is used in folk medicine to alleviate allergic reactions. The bee pollen phenolic extract (BPPE) consists in phenolic compounds (flavonoids) from plants picked by Apis mellifera bee. Aim of this study: Here we evaluated the anti-allergic property of the BPPE and the flavonoid myricetin (MYR) in murine model of ovalbumin (OVA)-induced allergy. Materials and methods: The study focused on the BPPE or myricetin treatment of OVA-sensitized BALB/c mice and their effects on the IgE and IgG1 production, pulmonary cell migration, eosinophil peroxidase (EPO) activity and anaphylactic shock reaction. Results: The BPPE treatment (200 mg/kg) showed inhibition of the paw edema, IgE and IgG1 OVA-specific production, leukocyte migration to the bronchoalveolar lavage (BAL) and EPO activity in lungs. In addition, BPPE treatment showed partial protection on the anaphylactic shock reaction induced by OVA. Treatment with myricetin (5 mg/kg) also inhibited pulmonary cell migration and IgE and IgG1 OVA-specific production. Conclusions: These results support the hypothesis themyricetin is one of the flavonoids of BPPE responsible for the anti-allergic effect and a potential tool to treat allergies.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-06-01T13:08:51Z No. of bitstreams: 1 __ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf: 278587 bytes, checksum: 1d969b03486fb42281cce4979dece7b2 (MD5)Made available in DSpace on 2012-06-01T13:08:51Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf: 278587 bytes, checksum: 1d969b03486fb42281cce4979dece7b2 (MD5) Previous issue date: 2008http://dx.doi.org/10.1016/j.jep.2008.05.036reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABee pollen phenolic extractMyricetinFlavonoidAllergyOvalbuminAnti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized miceJournal of Ethnopharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdfapplication/pdf278587https://repositorio.ufba.br/bitstream/ri/6043/1/__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf1d969b03486fb42281cce4979dece7b2MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6043/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf.txt__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf.txtExtracted texttext/plain36473https://repositorio.ufba.br/bitstream/ri/6043/3/__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf.txt22b1ad53c6f64ffb5a4c56aab045a478MD53ri/60432022-07-05 14:03:02.393oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:02Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
dc.title.alternative.pt_BR.fl_str_mv Journal of Ethnopharmacology
title Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
spellingShingle Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
Medeiros, K. C. P.
Bee pollen phenolic extract
Myricetin
Flavonoid
Allergy
Ovalbumin
title_short Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_full Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_fullStr Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_full_unstemmed Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
title_sort Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
author Medeiros, K. C. P.
author_facet Medeiros, K. C. P.
Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
author_role author
author2 Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Medeiros, K. C. P.
Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
Medeiros, K. C. P.
Figueiredo, C. A. V.
Figueredo, T. B.
Freire, K. R. L.
Santos, F. A. R.
Alcântara-Neves, Neuza Maria
Silva, T. M. S.
Piuvezam, M. R.
dc.subject.por.fl_str_mv Bee pollen phenolic extract
Myricetin
Flavonoid
Allergy
Ovalbumin
topic Bee pollen phenolic extract
Myricetin
Flavonoid
Allergy
Ovalbumin
description Acesso restrito: Texto completo. p. 41-46.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-06-01T13:08:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6043
dc.identifier.issn.none.fl_str_mv 0378-8741
dc.identifier.number.pt_BR.fl_str_mv v. 119, n. 1
identifier_str_mv 0378-8741
v. 119, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6043
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.jep.2008.05.036
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/6043/1/__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf
https://repositorio.ufba.br/bitstream/ri/6043/2/license.txt
https://repositorio.ufba.br/bitstream/ri/6043/3/__ac.els-cdn.com_S037887...c601a2038c703f77012e17c7d67a3.pdf.txt
bitstream.checksum.fl_str_mv 1d969b03486fb42281cce4979dece7b2
1b89a9a0548218172d7c829f87a0eab9
22b1ad53c6f64ffb5a4c56aab045a478
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459400265859072

Registros relacionados