Reactive oxygen species and redox signaling in breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Capítulo de livro |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1201/b20228 http://hdl.handle.net/11449/221146 |
Resumo: | Breast cancer progression depends on host innate and adaptive immune responses. Despite the effect of immune system in tumor destruction, cancer cells may induce the immune cells to support tumor progression. During tumor-host interactions, both tumor and immune cells produce significant amounts of reactive species (RS). The imbalance resulting from RS production and its neutralization is called oxidative stress, and it modulates several cellular processes impacting breast cancer outcome. Two major sensors of these processes are the nuclear factor erythroid-derived 2-related factor 2 (NRF2) and NF-κB-related pathways. The transcriptional factor NF-?B has prooxidant capacity, while Nrf2 has neutralizing action. NF-κB is a regulator of innate immunity, and it induces RS production and inflammatory cytokines. Furthermore, high level of NF-κB is found for breast cancer, and its downstream signaling has been implicated in aggressive tumor features. The redox sensor NRF2 is activated under oxidative stress conditions and induces human antioxidant response element in order to control cellular homeostasis; however, it protects tumors against RS caused by chemotherapy leading to treatment resistance. This chapter raises the discussion regarding the redox mechanisms involved in breast cancer development driven by the activation of the Nrf2-NF-κB axis. |
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Reactive oxygen species and redox signaling in breast cancerBreast cancer progression depends on host innate and adaptive immune responses. Despite the effect of immune system in tumor destruction, cancer cells may induce the immune cells to support tumor progression. During tumor-host interactions, both tumor and immune cells produce significant amounts of reactive species (RS). The imbalance resulting from RS production and its neutralization is called oxidative stress, and it modulates several cellular processes impacting breast cancer outcome. Two major sensors of these processes are the nuclear factor erythroid-derived 2-related factor 2 (NRF2) and NF-κB-related pathways. The transcriptional factor NF-?B has prooxidant capacity, while Nrf2 has neutralizing action. NF-κB is a regulator of innate immunity, and it induces RS production and inflammatory cytokines. Furthermore, high level of NF-κB is found for breast cancer, and its downstream signaling has been implicated in aggressive tumor features. The redox sensor NRF2 is activated under oxidative stress conditions and induces human antioxidant response element in order to control cellular homeostasis; however, it protects tumors against RS caused by chemotherapy leading to treatment resistance. This chapter raises the discussion regarding the redox mechanisms involved in breast cancer development driven by the activation of the Nrf2-NF-κB axis.Laboratory of Inflammatory Mediators State University of West Paraná UnioesteLaboratory of Stem Cells National Cancer Institute IncaDepartment of Chemistry and Environmental Sciences Sao Paulo State UniversityFaculty of Medicine University of São PauloDepartment of Chemistry and Environmental Sciences Sao Paulo State UniversityUnioesteIncaUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Panis, CarolinaPires, Bruno Ricardo BarretoDe Andrade, Ana CarolinaSilva, Mateus Batista [UNESP]Victorino, Vanessa Jacob2022-04-28T19:11:01Z2022-04-28T19:11:01Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart243-257http://dx.doi.org/10.1201/b20228Reactive Oxygen Species in Biology and Human Health, p. 243-257.http://hdl.handle.net/11449/22114610.1201/b202282-s2.0-85051933605Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReactive Oxygen Species in Biology and Human Healthinfo:eu-repo/semantics/openAccess2022-04-28T19:11:01Zoai:repositorio.unesp.br:11449/221146Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:10:48.025504Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Reactive oxygen species and redox signaling in breast cancer |
title |
Reactive oxygen species and redox signaling in breast cancer |
spellingShingle |
Reactive oxygen species and redox signaling in breast cancer Panis, Carolina |
title_short |
Reactive oxygen species and redox signaling in breast cancer |
title_full |
Reactive oxygen species and redox signaling in breast cancer |
title_fullStr |
Reactive oxygen species and redox signaling in breast cancer |
title_full_unstemmed |
Reactive oxygen species and redox signaling in breast cancer |
title_sort |
Reactive oxygen species and redox signaling in breast cancer |
author |
Panis, Carolina |
author_facet |
Panis, Carolina Pires, Bruno Ricardo Barreto De Andrade, Ana Carolina Silva, Mateus Batista [UNESP] Victorino, Vanessa Jacob |
author_role |
author |
author2 |
Pires, Bruno Ricardo Barreto De Andrade, Ana Carolina Silva, Mateus Batista [UNESP] Victorino, Vanessa Jacob |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Unioeste Inca Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Panis, Carolina Pires, Bruno Ricardo Barreto De Andrade, Ana Carolina Silva, Mateus Batista [UNESP] Victorino, Vanessa Jacob |
description |
Breast cancer progression depends on host innate and adaptive immune responses. Despite the effect of immune system in tumor destruction, cancer cells may induce the immune cells to support tumor progression. During tumor-host interactions, both tumor and immune cells produce significant amounts of reactive species (RS). The imbalance resulting from RS production and its neutralization is called oxidative stress, and it modulates several cellular processes impacting breast cancer outcome. Two major sensors of these processes are the nuclear factor erythroid-derived 2-related factor 2 (NRF2) and NF-κB-related pathways. The transcriptional factor NF-?B has prooxidant capacity, while Nrf2 has neutralizing action. NF-κB is a regulator of innate immunity, and it induces RS production and inflammatory cytokines. Furthermore, high level of NF-κB is found for breast cancer, and its downstream signaling has been implicated in aggressive tumor features. The redox sensor NRF2 is activated under oxidative stress conditions and induces human antioxidant response element in order to control cellular homeostasis; however, it protects tumors against RS caused by chemotherapy leading to treatment resistance. This chapter raises the discussion regarding the redox mechanisms involved in breast cancer development driven by the activation of the Nrf2-NF-κB axis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2022-04-28T19:11:01Z 2022-04-28T19:11:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bookPart |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1201/b20228 Reactive Oxygen Species in Biology and Human Health, p. 243-257. http://hdl.handle.net/11449/221146 10.1201/b20228 2-s2.0-85051933605 |
url |
http://dx.doi.org/10.1201/b20228 http://hdl.handle.net/11449/221146 |
identifier_str_mv |
Reactive Oxygen Species in Biology and Human Health, p. 243-257. 10.1201/b20228 2-s2.0-85051933605 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reactive Oxygen Species in Biology and Human Health |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
243-257 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128905898360832 |