Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sboportal.org.br/rbo/2006/rbo_set_out_2006.pdf http://hdl.handle.net/11449/69397 |
Resumo: | Purpose: This study intends to evaluate BMP (Bone Morphogenetic Protein) implant and BMP implant plus PRP (Platelet Rich Plasma) in rabbit orbital fractures, searching for tissue reaction, by radiological and morfometrical analysis. Methods:Third six white rabbits were submitted to orbital floor fracture and distributed in three groups: G1, with rabbits receiving a plate containing decalcified bone matrix and BMP; G2, with rabbits receiving the implant with BMP wrapped by PRP; G3, the control group where it was made the fracture only. The animals were evaluated radiologically after surgery and at sacrifice time in 7, 30, 90 and 180th day after surgery. After sacrifice, a block containing the right orbital tissue was extracted and prepared to morphological and morphometrical analysis. Results: An intensive linfomononuclear inflammatory reaction was observed at 7th day in G1 e G2, witch decreased after the 30th day; mesenchimal cells, osteoblasts, new bone and progressive cavitation of the implant were also observed, besides signs of calcium deposition by radiological study. In the control group fibrosis at the site of fracture was identified only. Conclusion: BMP seemed a good orbital implant producing new bone at the implant site and correcting bone defect.There was not observed acceleration of osteoinduction when the implant was associated with PRP. |
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Repositório Institucional da UNESP |
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Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitáriasBone morphogenetic protein (bmp) implant associated with platelet rich plasma in orbit fracture repair - experimental studyBlood plateletsBone morphogenetic proteins/therapeutic useBone remodelingOrbital fracturesPlasmaPurpose: This study intends to evaluate BMP (Bone Morphogenetic Protein) implant and BMP implant plus PRP (Platelet Rich Plasma) in rabbit orbital fractures, searching for tissue reaction, by radiological and morfometrical analysis. Methods:Third six white rabbits were submitted to orbital floor fracture and distributed in three groups: G1, with rabbits receiving a plate containing decalcified bone matrix and BMP; G2, with rabbits receiving the implant with BMP wrapped by PRP; G3, the control group where it was made the fracture only. The animals were evaluated radiologically after surgery and at sacrifice time in 7, 30, 90 and 180th day after surgery. After sacrifice, a block containing the right orbital tissue was extracted and prepared to morphological and morphometrical analysis. Results: An intensive linfomononuclear inflammatory reaction was observed at 7th day in G1 e G2, witch decreased after the 30th day; mesenchimal cells, osteoblasts, new bone and progressive cavitation of the implant were also observed, besides signs of calcium deposition by radiological study. In the control group fibrosis at the site of fracture was identified only. Conclusion: BMP seemed a good orbital implant producing new bone at the implant site and correcting bone defect.There was not observed acceleration of osteoinduction when the implant was associated with PRP.Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Morfologia e Histologia Instituto de Biociências Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Radiologia Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Morfologia e Histologia Instituto de Biociências Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Radiologia Faculdade de Medicina Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Departamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista Júlio Mesquita Filho - UNESP, Botucatu (SP)Universidade Estadual Paulista (Unesp)Da Silva Ferraz, Fábio Henrique [UNESP]Schellini, Silvana Artioli [UNESP]Pellizzon, Cláudia Helena [UNESP]De Campos Schellini, Ricardo [UNESP]Padovani, Carlos Roberto [UNESP]2014-05-27T11:22:20Z2014-05-27T11:22:20Z2006-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article273-284application/pdfhttp://www.sboportal.org.br/rbo/2006/rbo_set_out_2006.pdfRevista Brasileira de Oftalmologia, v. 65, n. 5, p. 273-284, 2006.0034-72801982-8551http://hdl.handle.net/11449/693972-s2.0-779518965192-s2.0-77951896519.pdf9420249100835492872789708052228900193937798010690000-0002-4494-4180Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Oftalmologia0,147info:eu-repo/semantics/openAccess2023-11-03T06:09:50Zoai:repositorio.unesp.br:11449/69397Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-03T06:09:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias Bone morphogenetic protein (bmp) implant associated with platelet rich plasma in orbit fracture repair - experimental study |
title |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias |
spellingShingle |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias Da Silva Ferraz, Fábio Henrique [UNESP] Blood platelets Bone morphogenetic proteins/therapeutic use Bone remodeling Orbital fractures Plasma |
title_short |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias |
title_full |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias |
title_fullStr |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias |
title_full_unstemmed |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias |
title_sort |
Comportamento do implante contendo bone morphogenetic protein (bmp) associado ao plasma rico em plaquetas na reparação de fraturas orbitárias |
author |
Da Silva Ferraz, Fábio Henrique [UNESP] |
author_facet |
Da Silva Ferraz, Fábio Henrique [UNESP] Schellini, Silvana Artioli [UNESP] Pellizzon, Cláudia Helena [UNESP] De Campos Schellini, Ricardo [UNESP] Padovani, Carlos Roberto [UNESP] |
author_role |
author |
author2 |
Schellini, Silvana Artioli [UNESP] Pellizzon, Cláudia Helena [UNESP] De Campos Schellini, Ricardo [UNESP] Padovani, Carlos Roberto [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Da Silva Ferraz, Fábio Henrique [UNESP] Schellini, Silvana Artioli [UNESP] Pellizzon, Cláudia Helena [UNESP] De Campos Schellini, Ricardo [UNESP] Padovani, Carlos Roberto [UNESP] |
dc.subject.por.fl_str_mv |
Blood platelets Bone morphogenetic proteins/therapeutic use Bone remodeling Orbital fractures Plasma |
topic |
Blood platelets Bone morphogenetic proteins/therapeutic use Bone remodeling Orbital fractures Plasma |
description |
Purpose: This study intends to evaluate BMP (Bone Morphogenetic Protein) implant and BMP implant plus PRP (Platelet Rich Plasma) in rabbit orbital fractures, searching for tissue reaction, by radiological and morfometrical analysis. Methods:Third six white rabbits were submitted to orbital floor fracture and distributed in three groups: G1, with rabbits receiving a plate containing decalcified bone matrix and BMP; G2, with rabbits receiving the implant with BMP wrapped by PRP; G3, the control group where it was made the fracture only. The animals were evaluated radiologically after surgery and at sacrifice time in 7, 30, 90 and 180th day after surgery. After sacrifice, a block containing the right orbital tissue was extracted and prepared to morphological and morphometrical analysis. Results: An intensive linfomononuclear inflammatory reaction was observed at 7th day in G1 e G2, witch decreased after the 30th day; mesenchimal cells, osteoblasts, new bone and progressive cavitation of the implant were also observed, besides signs of calcium deposition by radiological study. In the control group fibrosis at the site of fracture was identified only. Conclusion: BMP seemed a good orbital implant producing new bone at the implant site and correcting bone defect.There was not observed acceleration of osteoinduction when the implant was associated with PRP. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-12-01 2014-05-27T11:22:20Z 2014-05-27T11:22:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sboportal.org.br/rbo/2006/rbo_set_out_2006.pdf Revista Brasileira de Oftalmologia, v. 65, n. 5, p. 273-284, 2006. 0034-7280 1982-8551 http://hdl.handle.net/11449/69397 2-s2.0-77951896519 2-s2.0-77951896519.pdf 9420249100835492 8727897080522289 0019393779801069 0000-0002-4494-4180 |
url |
http://www.sboportal.org.br/rbo/2006/rbo_set_out_2006.pdf http://hdl.handle.net/11449/69397 |
identifier_str_mv |
Revista Brasileira de Oftalmologia, v. 65, n. 5, p. 273-284, 2006. 0034-7280 1982-8551 2-s2.0-77951896519 2-s2.0-77951896519.pdf 9420249100835492 8727897080522289 0019393779801069 0000-0002-4494-4180 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Oftalmologia 0,147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
273-284 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046299699773440 |