Exosomes: Pros and cons for fighting cancer
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Capítulo de livro |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-3-030-50287-4_20 http://hdl.handle.net/11449/249678 |
Resumo: | Exosomes (Exo) are extracellular vesicles involved in intercellular communication. These nanovesicles are a mini reflection of the cell of origin, carrying several bioactive molecules, also reflecting the conditions of the extracellular environment. Exo can be a double-edged sword depending on their origin, so that tumor cell-derived Exo may be loaded with important tumor antigens to be presented to the immune system, but may also decrease the immunotherapeutic action of monoclonal antibodies. Moreover, tumor Exo carry many molecules with suppressive potential, subverting the immune response. Alternatively, Exo originating from antigen-presenting cells (APCs) such as dendritic cells (DCs) may directly or indirectly induce tumor-specific T lymphocyte response, both in vitro and in vivo, being clinically safe. Another clinically attractive factor of Exo is its use as a noninvasive liquid biopsy, which may facilitate diagnosis in the early phase of the disease. In addition, they can be used as biotechnological tools for loading bioactive drugs. |
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Exosomes: Pros and cons for fighting cancerCancerDendritic cellsDiagnosticExosomesExtracellular vesiclesImmunotherapyNanocarriersExosomes (Exo) are extracellular vesicles involved in intercellular communication. These nanovesicles are a mini reflection of the cell of origin, carrying several bioactive molecules, also reflecting the conditions of the extracellular environment. Exo can be a double-edged sword depending on their origin, so that tumor cell-derived Exo may be loaded with important tumor antigens to be presented to the immune system, but may also decrease the immunotherapeutic action of monoclonal antibodies. Moreover, tumor Exo carry many molecules with suppressive potential, subverting the immune response. Alternatively, Exo originating from antigen-presenting cells (APCs) such as dendritic cells (DCs) may directly or indirectly induce tumor-specific T lymphocyte response, both in vitro and in vivo, being clinically safe. Another clinically attractive factor of Exo is its use as a noninvasive liquid biopsy, which may facilitate diagnosis in the early phase of the disease. In addition, they can be used as biotechnological tools for loading bioactive drugs.Department of Pathology School of Medicine São Paulo State University - UNESPDepartment of Chemical and Biological Sciences Institute of Biosciences - São Paulo State University - UNESPDepartment Health Science Oeste Paulista University - UNOESTEDepartment of Pathology School of Medicine São Paulo State University - UNESPDepartment of Chemical and Biological Sciences Institute of Biosciences - São Paulo State University - UNESPUniversidade Estadual Paulista (UNESP)Oeste Paulista University - UNOESTERomagnoli, Graziela Gorete [UNESP]Gorgulho, Carolina Mendonça [UNESP]Kaneno, Ramon [UNESP]2023-07-29T16:06:13Z2023-07-29T16:06:13Z2020-09-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart373-382http://dx.doi.org/10.1007/978-3-030-50287-4_20Cancer Immunology: Bench to Bedside Immunotherapy of Cancers, Second Edition, p. 373-382.http://hdl.handle.net/11449/24967810.1007/978-3-030-50287-4_202-s2.0-85148481009Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCancer Immunology: Bench to Bedside Immunotherapy of Cancers, Second Editioninfo:eu-repo/semantics/openAccess2023-07-29T16:06:13Zoai:repositorio.unesp.br:11449/249678Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:48:02.301641Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exosomes: Pros and cons for fighting cancer |
title |
Exosomes: Pros and cons for fighting cancer |
spellingShingle |
Exosomes: Pros and cons for fighting cancer Romagnoli, Graziela Gorete [UNESP] Cancer Dendritic cells Diagnostic Exosomes Extracellular vesicles Immunotherapy Nanocarriers |
title_short |
Exosomes: Pros and cons for fighting cancer |
title_full |
Exosomes: Pros and cons for fighting cancer |
title_fullStr |
Exosomes: Pros and cons for fighting cancer |
title_full_unstemmed |
Exosomes: Pros and cons for fighting cancer |
title_sort |
Exosomes: Pros and cons for fighting cancer |
author |
Romagnoli, Graziela Gorete [UNESP] |
author_facet |
Romagnoli, Graziela Gorete [UNESP] Gorgulho, Carolina Mendonça [UNESP] Kaneno, Ramon [UNESP] |
author_role |
author |
author2 |
Gorgulho, Carolina Mendonça [UNESP] Kaneno, Ramon [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Oeste Paulista University - UNOESTE |
dc.contributor.author.fl_str_mv |
Romagnoli, Graziela Gorete [UNESP] Gorgulho, Carolina Mendonça [UNESP] Kaneno, Ramon [UNESP] |
dc.subject.por.fl_str_mv |
Cancer Dendritic cells Diagnostic Exosomes Extracellular vesicles Immunotherapy Nanocarriers |
topic |
Cancer Dendritic cells Diagnostic Exosomes Extracellular vesicles Immunotherapy Nanocarriers |
description |
Exosomes (Exo) are extracellular vesicles involved in intercellular communication. These nanovesicles are a mini reflection of the cell of origin, carrying several bioactive molecules, also reflecting the conditions of the extracellular environment. Exo can be a double-edged sword depending on their origin, so that tumor cell-derived Exo may be loaded with important tumor antigens to be presented to the immune system, but may also decrease the immunotherapeutic action of monoclonal antibodies. Moreover, tumor Exo carry many molecules with suppressive potential, subverting the immune response. Alternatively, Exo originating from antigen-presenting cells (APCs) such as dendritic cells (DCs) may directly or indirectly induce tumor-specific T lymphocyte response, both in vitro and in vivo, being clinically safe. Another clinically attractive factor of Exo is its use as a noninvasive liquid biopsy, which may facilitate diagnosis in the early phase of the disease. In addition, they can be used as biotechnological tools for loading bioactive drugs. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-24 2023-07-29T16:06:13Z 2023-07-29T16:06:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bookPart |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-3-030-50287-4_20 Cancer Immunology: Bench to Bedside Immunotherapy of Cancers, Second Edition, p. 373-382. http://hdl.handle.net/11449/249678 10.1007/978-3-030-50287-4_20 2-s2.0-85148481009 |
url |
http://dx.doi.org/10.1007/978-3-030-50287-4_20 http://hdl.handle.net/11449/249678 |
identifier_str_mv |
Cancer Immunology: Bench to Bedside Immunotherapy of Cancers, Second Edition, p. 373-382. 10.1007/978-3-030-50287-4_20 2-s2.0-85148481009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cancer Immunology: Bench to Bedside Immunotherapy of Cancers, Second Edition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
373-382 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129250063024128 |