Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil

Detalhes bibliográficos
Autor(a) principal: Maciel, Willian Giquelin [UNESP]
Data de Publicação: 2016
Outros Autores: Lopes, Welber Daniel Zanetti [UNESP], Gomes, Lucas Vinicius Costa [UNESP], Cruz, Breno Cayeiro [UNESP], Felippelli, Gustavo [UNESP], Santos, Isabella Barbosa Dos [UNESP], Borges, Fernando de Almeida, Gonçalves, Walter Antonio, Scarpa, Alexandre Braga, Nicaretta, João Eduardo, Bastos, Thiago Souza Azeredo, da Costa, Alvimar José [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.prevetmed.2016.10.019
http://hdl.handle.net/11449/173805
Resumo: The present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5 mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick were evaluated using in vivo field studies, regarding their susceptibility to a new combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg), administered subcutaneously, compared with two positive controls (fluazuron 2.5 mg/kg and eprinomectin 0.5 mg/kg), both administered topically (pour-on). Selected bovines were allocated to treatment groups on day 0, and block formation was based on arithmetic means of female ticks (4.5–8.0 mm long) counted on three consecutive days (−3, −2 and −1). To evaluate therapeutic and residual efficacies of these formulations, tick counts (females ranging from 4.5 to 8.0 mm long) were performed on days 3, 7 and 14 post-treatment, continuing on a weekly basis until the end of each experiment. Results obtained throughout this study, utilizing field efficacy trials, allowed us to conclude that four R. (B.) microplus populations (including two in the Southeast and two in the Midwest regions) could be diagnosed as resistant, or with low susceptibility, to fluazuron (2.5 mg/kg). Such fact was detected in farms where owners applied products containing this active component on cattle for at least five years, with treatment intervals of 30–55 days during the rainy season. Nonetheless, in vitro studies should be performed in order to reinforce in vivo results obtained on the present study. Regarding efficacy indexes obtained by the association of eprinomectin and the novel molecule novaluron against R. (B.) microplus, none of the trials managed to obtain efficacies superior to 48%. Such results, allied to data obtained by different researchers and previously published in literature, reinforce the perception that maybe these formulations containing novaluron, in the administered dosages and treatment routes, may not be effective tools for controlling R. (B.) microplus. However, future studies must be conducted in order to support such hypothesis. Additionally, all five R. (B.) microplus populations were diagnosed as resistant, or with low susceptibility, to eprinomectin (0.5 mg/kg) as well. Even though fluazuron, administered topically (pour on), is still an excellent active principle to be used against R. (B.) microplus, resistance management strategies should be quickly implemented in order to keep selection pressure in Brazil at a minimum level for this compound.
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spelling Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in BrazilBenzoylphenyl ureaCattleMacrocyclic lactoneResistanceTicksThe present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5 mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick were evaluated using in vivo field studies, regarding their susceptibility to a new combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg), administered subcutaneously, compared with two positive controls (fluazuron 2.5 mg/kg and eprinomectin 0.5 mg/kg), both administered topically (pour-on). Selected bovines were allocated to treatment groups on day 0, and block formation was based on arithmetic means of female ticks (4.5–8.0 mm long) counted on three consecutive days (−3, −2 and −1). To evaluate therapeutic and residual efficacies of these formulations, tick counts (females ranging from 4.5 to 8.0 mm long) were performed on days 3, 7 and 14 post-treatment, continuing on a weekly basis until the end of each experiment. Results obtained throughout this study, utilizing field efficacy trials, allowed us to conclude that four R. (B.) microplus populations (including two in the Southeast and two in the Midwest regions) could be diagnosed as resistant, or with low susceptibility, to fluazuron (2.5 mg/kg). Such fact was detected in farms where owners applied products containing this active component on cattle for at least five years, with treatment intervals of 30–55 days during the rainy season. Nonetheless, in vitro studies should be performed in order to reinforce in vivo results obtained on the present study. Regarding efficacy indexes obtained by the association of eprinomectin and the novel molecule novaluron against R. (B.) microplus, none of the trials managed to obtain efficacies superior to 48%. Such results, allied to data obtained by different researchers and previously published in literature, reinforce the perception that maybe these formulations containing novaluron, in the administered dosages and treatment routes, may not be effective tools for controlling R. (B.) microplus. However, future studies must be conducted in order to support such hypothesis. Additionally, all five R. (B.) microplus populations were diagnosed as resistant, or with low susceptibility, to eprinomectin (0.5 mg/kg) as well. Even though fluazuron, administered topically (pour on), is still an excellent active principle to be used against R. (B.) microplus, resistance management strategies should be quickly implemented in order to keep selection pressure in Brazil at a minimum level for this compound.CPPAR − Animal Health Research Center Faculdade de Ciências Agrárias e Veterinárias UNESP Jaboticabal Campus, Access Route Prof. Paulo Donato Castellane, JaboticabalInstituto de Patologia Tropical e Saúde Pública Universidade Federal de Goiás (IPTSP/EVZ/UFG)Universidade Federal do Mato Grosso do Sul (UFMS)Universidade Estadual de Maringá Umuarama Regional CampusUniversidade Federal de Goiás, Regional de JataíCPPAR − Animal Health Research Center Faculdade de Ciências Agrárias e Veterinárias UNESP Jaboticabal Campus, Access Route Prof. Paulo Donato Castellane, JaboticabalUniversidade Estadual Paulista (Unesp)Universidade Federal de Goiás (UFG)Universidade Federal de Mato Grosso do Sul (UFMS)Universidade Estadual de Maringá (UEM)Maciel, Willian Giquelin [UNESP]Lopes, Welber Daniel Zanetti [UNESP]Gomes, Lucas Vinicius Costa [UNESP]Cruz, Breno Cayeiro [UNESP]Felippelli, Gustavo [UNESP]Santos, Isabella Barbosa Dos [UNESP]Borges, Fernando de AlmeidaGonçalves, Walter AntonioScarpa, Alexandre BragaNicaretta, João EduardoBastos, Thiago Souza Azeredoda Costa, Alvimar José [UNESP]2018-12-11T17:07:50Z2018-12-11T17:07:50Z2016-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article74-86application/pdfhttp://dx.doi.org/10.1016/j.prevetmed.2016.10.019Preventive Veterinary Medicine, v. 135, p. 74-86.0167-5877http://hdl.handle.net/11449/17380510.1016/j.prevetmed.2016.10.0192-s2.0-849957524522-s2.0-84995752452.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPreventive Veterinary Medicine1,144info:eu-repo/semantics/openAccess2024-04-12T13:07:00Zoai:repositorio.unesp.br:11449/173805Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:46:51.227120Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
title Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
spellingShingle Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
Maciel, Willian Giquelin [UNESP]
Benzoylphenyl urea
Cattle
Macrocyclic lactone
Resistance
Ticks
title_short Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
title_full Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
title_fullStr Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
title_full_unstemmed Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
title_sort Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil
author Maciel, Willian Giquelin [UNESP]
author_facet Maciel, Willian Giquelin [UNESP]
Lopes, Welber Daniel Zanetti [UNESP]
Gomes, Lucas Vinicius Costa [UNESP]
Cruz, Breno Cayeiro [UNESP]
Felippelli, Gustavo [UNESP]
Santos, Isabella Barbosa Dos [UNESP]
Borges, Fernando de Almeida
Gonçalves, Walter Antonio
Scarpa, Alexandre Braga
Nicaretta, João Eduardo
Bastos, Thiago Souza Azeredo
da Costa, Alvimar José [UNESP]
author_role author
author2 Lopes, Welber Daniel Zanetti [UNESP]
Gomes, Lucas Vinicius Costa [UNESP]
Cruz, Breno Cayeiro [UNESP]
Felippelli, Gustavo [UNESP]
Santos, Isabella Barbosa Dos [UNESP]
Borges, Fernando de Almeida
Gonçalves, Walter Antonio
Scarpa, Alexandre Braga
Nicaretta, João Eduardo
Bastos, Thiago Souza Azeredo
da Costa, Alvimar José [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Goiás (UFG)
Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Estadual de Maringá (UEM)
dc.contributor.author.fl_str_mv Maciel, Willian Giquelin [UNESP]
Lopes, Welber Daniel Zanetti [UNESP]
Gomes, Lucas Vinicius Costa [UNESP]
Cruz, Breno Cayeiro [UNESP]
Felippelli, Gustavo [UNESP]
Santos, Isabella Barbosa Dos [UNESP]
Borges, Fernando de Almeida
Gonçalves, Walter Antonio
Scarpa, Alexandre Braga
Nicaretta, João Eduardo
Bastos, Thiago Souza Azeredo
da Costa, Alvimar José [UNESP]
dc.subject.por.fl_str_mv Benzoylphenyl urea
Cattle
Macrocyclic lactone
Resistance
Ticks
topic Benzoylphenyl urea
Cattle
Macrocyclic lactone
Resistance
Ticks
description The present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5 mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick were evaluated using in vivo field studies, regarding their susceptibility to a new combination of novaluron (2.0 mg/kg) + eprinomectin (0.36 mg/kg), administered subcutaneously, compared with two positive controls (fluazuron 2.5 mg/kg and eprinomectin 0.5 mg/kg), both administered topically (pour-on). Selected bovines were allocated to treatment groups on day 0, and block formation was based on arithmetic means of female ticks (4.5–8.0 mm long) counted on three consecutive days (−3, −2 and −1). To evaluate therapeutic and residual efficacies of these formulations, tick counts (females ranging from 4.5 to 8.0 mm long) were performed on days 3, 7 and 14 post-treatment, continuing on a weekly basis until the end of each experiment. Results obtained throughout this study, utilizing field efficacy trials, allowed us to conclude that four R. (B.) microplus populations (including two in the Southeast and two in the Midwest regions) could be diagnosed as resistant, or with low susceptibility, to fluazuron (2.5 mg/kg). Such fact was detected in farms where owners applied products containing this active component on cattle for at least five years, with treatment intervals of 30–55 days during the rainy season. Nonetheless, in vitro studies should be performed in order to reinforce in vivo results obtained on the present study. Regarding efficacy indexes obtained by the association of eprinomectin and the novel molecule novaluron against R. (B.) microplus, none of the trials managed to obtain efficacies superior to 48%. Such results, allied to data obtained by different researchers and previously published in literature, reinforce the perception that maybe these formulations containing novaluron, in the administered dosages and treatment routes, may not be effective tools for controlling R. (B.) microplus. However, future studies must be conducted in order to support such hypothesis. Additionally, all five R. (B.) microplus populations were diagnosed as resistant, or with low susceptibility, to eprinomectin (0.5 mg/kg) as well. Even though fluazuron, administered topically (pour on), is still an excellent active principle to be used against R. (B.) microplus, resistance management strategies should be quickly implemented in order to keep selection pressure in Brazil at a minimum level for this compound.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
2018-12-11T17:07:50Z
2018-12-11T17:07:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.prevetmed.2016.10.019
Preventive Veterinary Medicine, v. 135, p. 74-86.
0167-5877
http://hdl.handle.net/11449/173805
10.1016/j.prevetmed.2016.10.019
2-s2.0-84995752452
2-s2.0-84995752452.pdf
url http://dx.doi.org/10.1016/j.prevetmed.2016.10.019
http://hdl.handle.net/11449/173805
identifier_str_mv Preventive Veterinary Medicine, v. 135, p. 74-86.
0167-5877
10.1016/j.prevetmed.2016.10.019
2-s2.0-84995752452
2-s2.0-84995752452.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Preventive Veterinary Medicine
1,144
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 74-86
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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