Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/polym9090391 http://hdl.handle.net/11449/179129 |
Resumo: | Oxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratum corneum was evaluated by a non-invasive method. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 ± 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress. |
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Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assaysAntioxidantsGallic acidPolymersSkin administrationOxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratum corneum was evaluated by a non-invasive method. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 ± 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress.Medicine Department Federal University of Sao Paulo (UNIFESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Food Science São Paulo University (USP)Institute of Environmental Chemistry and Pharmaceutical Sciences Federal University of Sao Paulo (UNIFESP)Faculty of Pharmaceuticals Sciences University of Campinas (UNICAMP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Monteiro e Silva, Silas ArandasCalixto, Giovana Maria Fioramonti [UNESP]Cajado, Julianade Carvalho, Patrícia Caballieri AntunesRodero, Camila Fernanda [UNESP]Chorilli, Marlus [UNESP]Leonardi, Gislaine Ricci2018-12-11T17:33:52Z2018-12-11T17:33:52Z2017-08-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/polym9090391Polymers, v. 9, n. 9, 2017.2073-4360http://hdl.handle.net/11449/17912910.3390/polym90903912-s2.0-850284062702-s2.0-85028406270.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPolymers0,852info:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/179129Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:42:26.391973Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
title |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
spellingShingle |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays Monteiro e Silva, Silas Arandas Antioxidants Gallic acid Polymers Skin administration |
title_short |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
title_full |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
title_fullStr |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
title_full_unstemmed |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
title_sort |
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays |
author |
Monteiro e Silva, Silas Arandas |
author_facet |
Monteiro e Silva, Silas Arandas Calixto, Giovana Maria Fioramonti [UNESP] Cajado, Juliana de Carvalho, Patrícia Caballieri Antunes Rodero, Camila Fernanda [UNESP] Chorilli, Marlus [UNESP] Leonardi, Gislaine Ricci |
author_role |
author |
author2 |
Calixto, Giovana Maria Fioramonti [UNESP] Cajado, Juliana de Carvalho, Patrícia Caballieri Antunes Rodero, Camila Fernanda [UNESP] Chorilli, Marlus [UNESP] Leonardi, Gislaine Ricci |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Monteiro e Silva, Silas Arandas Calixto, Giovana Maria Fioramonti [UNESP] Cajado, Juliana de Carvalho, Patrícia Caballieri Antunes Rodero, Camila Fernanda [UNESP] Chorilli, Marlus [UNESP] Leonardi, Gislaine Ricci |
dc.subject.por.fl_str_mv |
Antioxidants Gallic acid Polymers Skin administration |
topic |
Antioxidants Gallic acid Polymers Skin administration |
description |
Oxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratum corneum was evaluated by a non-invasive method. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 ± 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-24 2018-12-11T17:33:52Z 2018-12-11T17:33:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/polym9090391 Polymers, v. 9, n. 9, 2017. 2073-4360 http://hdl.handle.net/11449/179129 10.3390/polym9090391 2-s2.0-85028406270 2-s2.0-85028406270.pdf |
url |
http://dx.doi.org/10.3390/polym9090391 http://hdl.handle.net/11449/179129 |
identifier_str_mv |
Polymers, v. 9, n. 9, 2017. 2073-4360 10.3390/polym9090391 2-s2.0-85028406270 2-s2.0-85028406270.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Polymers 0,852 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129107865632768 |