HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/coa.13640 http://hdl.handle.net/11449/206542 |
Resumo: | Objectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease. |
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HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in childrenhuman papillomavirusoutcomerecurrent respiratory papillomatosissurgerytypevariantObjectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo (USP)Department of Biology IBILCE Institute of Bioscience Language & Literature and Exact Science University of São Paulo State (UNESP)Department of Pediatrics Ribeirão Preto Medical School University of São Paulo (USP)Laboratory of Research in Virology School of Medicine of São José do Rio Preto FAMERPDepartment of Biology IBILCE Institute of Bioscience Language & Literature and Exact Science University of São Paulo State (UNESP)FAPESP: 10/00029-0FAPESP: CNPqUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)FAMERPNogueira, Rodrigo L.Küpper, Daniel S.do Bonfim, Caroline M. [UNESP]Aragon, Davi C.Damico, Thiago A.Miura, Carolina S.Passos, Ivna M.Nogueira, Maurício L.Rahal, Paula [UNESP]Valera, Fabiana C. P.2021-06-25T10:34:01Z2021-06-25T10:34:01Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article181-188http://dx.doi.org/10.1111/coa.13640Clinical Otolaryngology, v. 46, n. 1, p. 181-188, 2021.1749-44861749-4478http://hdl.handle.net/11449/20654210.1111/coa.136402-s2.0-85091267512Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Otolaryngologyinfo:eu-repo/semantics/openAccess2021-10-23T07:21:27Zoai:repositorio.unesp.br:11449/206542Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:41:39.782525Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
title |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
spellingShingle |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children Nogueira, Rodrigo L. human papillomavirus outcome recurrent respiratory papillomatosis surgery type variant |
title_short |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
title_full |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
title_fullStr |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
title_full_unstemmed |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
title_sort |
HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children |
author |
Nogueira, Rodrigo L. |
author_facet |
Nogueira, Rodrigo L. Küpper, Daniel S. do Bonfim, Caroline M. [UNESP] Aragon, Davi C. Damico, Thiago A. Miura, Carolina S. Passos, Ivna M. Nogueira, Maurício L. Rahal, Paula [UNESP] Valera, Fabiana C. P. |
author_role |
author |
author2 |
Küpper, Daniel S. do Bonfim, Caroline M. [UNESP] Aragon, Davi C. Damico, Thiago A. Miura, Carolina S. Passos, Ivna M. Nogueira, Maurício L. Rahal, Paula [UNESP] Valera, Fabiana C. P. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) FAMERP |
dc.contributor.author.fl_str_mv |
Nogueira, Rodrigo L. Küpper, Daniel S. do Bonfim, Caroline M. [UNESP] Aragon, Davi C. Damico, Thiago A. Miura, Carolina S. Passos, Ivna M. Nogueira, Maurício L. Rahal, Paula [UNESP] Valera, Fabiana C. P. |
dc.subject.por.fl_str_mv |
human papillomavirus outcome recurrent respiratory papillomatosis surgery type variant |
topic |
human papillomavirus outcome recurrent respiratory papillomatosis surgery type variant |
description |
Objectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:34:01Z 2021-06-25T10:34:01Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/coa.13640 Clinical Otolaryngology, v. 46, n. 1, p. 181-188, 2021. 1749-4486 1749-4478 http://hdl.handle.net/11449/206542 10.1111/coa.13640 2-s2.0-85091267512 |
url |
http://dx.doi.org/10.1111/coa.13640 http://hdl.handle.net/11449/206542 |
identifier_str_mv |
Clinical Otolaryngology, v. 46, n. 1, p. 181-188, 2021. 1749-4486 1749-4478 10.1111/coa.13640 2-s2.0-85091267512 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Otolaryngology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
181-188 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129451637080064 |