HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children

Detalhes bibliográficos
Autor(a) principal: Nogueira, Rodrigo L.
Data de Publicação: 2021
Outros Autores: Küpper, Daniel S., do Bonfim, Caroline M. [UNESP], Aragon, Davi C., Damico, Thiago A., Miura, Carolina S., Passos, Ivna M., Nogueira, Maurício L., Rahal, Paula [UNESP], Valera, Fabiana C. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/coa.13640
http://hdl.handle.net/11449/206542
Resumo: Objectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease.
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spelling HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in childrenhuman papillomavirusoutcomerecurrent respiratory papillomatosissurgerytypevariantObjectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo (USP)Department of Biology IBILCE Institute of Bioscience Language & Literature and Exact Science University of São Paulo State (UNESP)Department of Pediatrics Ribeirão Preto Medical School University of São Paulo (USP)Laboratory of Research in Virology School of Medicine of São José do Rio Preto FAMERPDepartment of Biology IBILCE Institute of Bioscience Language & Literature and Exact Science University of São Paulo State (UNESP)FAPESP: 10/00029-0FAPESP: CNPqUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)FAMERPNogueira, Rodrigo L.Küpper, Daniel S.do Bonfim, Caroline M. [UNESP]Aragon, Davi C.Damico, Thiago A.Miura, Carolina S.Passos, Ivna M.Nogueira, Maurício L.Rahal, Paula [UNESP]Valera, Fabiana C. P.2021-06-25T10:34:01Z2021-06-25T10:34:01Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article181-188http://dx.doi.org/10.1111/coa.13640Clinical Otolaryngology, v. 46, n. 1, p. 181-188, 2021.1749-44861749-4478http://hdl.handle.net/11449/20654210.1111/coa.136402-s2.0-85091267512Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Otolaryngologyinfo:eu-repo/semantics/openAccess2021-10-23T07:21:27Zoai:repositorio.unesp.br:11449/206542Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:41:39.782525Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
title HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
spellingShingle HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
Nogueira, Rodrigo L.
human papillomavirus
outcome
recurrent respiratory papillomatosis
surgery
type
variant
title_short HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
title_full HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
title_fullStr HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
title_full_unstemmed HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
title_sort HPV genotype is a prognosticator for recurrence of respiratory papillomatosis in children
author Nogueira, Rodrigo L.
author_facet Nogueira, Rodrigo L.
Küpper, Daniel S.
do Bonfim, Caroline M. [UNESP]
Aragon, Davi C.
Damico, Thiago A.
Miura, Carolina S.
Passos, Ivna M.
Nogueira, Maurício L.
Rahal, Paula [UNESP]
Valera, Fabiana C. P.
author_role author
author2 Küpper, Daniel S.
do Bonfim, Caroline M. [UNESP]
Aragon, Davi C.
Damico, Thiago A.
Miura, Carolina S.
Passos, Ivna M.
Nogueira, Maurício L.
Rahal, Paula [UNESP]
Valera, Fabiana C. P.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
FAMERP
dc.contributor.author.fl_str_mv Nogueira, Rodrigo L.
Küpper, Daniel S.
do Bonfim, Caroline M. [UNESP]
Aragon, Davi C.
Damico, Thiago A.
Miura, Carolina S.
Passos, Ivna M.
Nogueira, Maurício L.
Rahal, Paula [UNESP]
Valera, Fabiana C. P.
dc.subject.por.fl_str_mv human papillomavirus
outcome
recurrent respiratory papillomatosis
surgery
type
variant
topic human papillomavirus
outcome
recurrent respiratory papillomatosis
surgery
type
variant
description Objectives: This study aimed to compare the prognosis according to age, genotype or human papillomavirus (HPV) variant in patients with recurrent respiratory papillomatosis (RRP). Design: Non-concurrent cohort. Participants: Forty one patients with RRP. Setting: Tertiary referral hospital. Main Outcome Measures: Disease severity was defined by the number of surgeries performed, and Derkay score at surgeries, obtained from medical records. HPV was detected and genotyped, and HPV-6 variants were also assessed. Results: Fifteen (36.58%) individuals belonged to the juvenile RRP group (JoRRP, less than 18 years), while 26 patients (63.41%) were allocated at the adult group (AoRRP, equal or more than 18 years). JoRRP patients needed, in average, a higher number of surgeries to control the disease than AoRRP patients (mean difference: 3.36). Also, JoRRP patients showed a higher Derkay score at each surgery (mean difference: 3.76). There was no significant difference in the number of surgeries when we compared patients infected with HPV-6 or HPV-11, neither in accordance to HPV-6 variants. Patients with HPV-11 presented a higher mean Derkay score at surgery than those with HPV-6 (mean difference: 4.39); when co-variated by age, we observed that this difference occurred only among JoRRP patients (mean difference: 6.15). Conclusions: Age of onset of RRP has an important impact on number of surgeries to control disease. Patients with JoRRP and HPV-11 tend to present worse Derkay score at each surgery. HPV genotype among adults and HPV-6 variants had no impact on the outcome of the disease.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:34:01Z
2021-06-25T10:34:01Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/coa.13640
Clinical Otolaryngology, v. 46, n. 1, p. 181-188, 2021.
1749-4486
1749-4478
http://hdl.handle.net/11449/206542
10.1111/coa.13640
2-s2.0-85091267512
url http://dx.doi.org/10.1111/coa.13640
http://hdl.handle.net/11449/206542
identifier_str_mv Clinical Otolaryngology, v. 46, n. 1, p. 181-188, 2021.
1749-4486
1749-4478
10.1111/coa.13640
2-s2.0-85091267512
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Otolaryngology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 181-188
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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