Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/molecules23050986 http://hdl.handle.net/11449/176240 |
Resumo: | Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL− 1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL− 1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL− 1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL− 1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants. |
id |
UNSP_c54fe99fc721ceb58611e9daf7775105 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/176240 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia speciesBiological activitiesESI(−)Q-TOF-MSMyrcia spp.Phenolic compoundsMyrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL− 1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL− 1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL− 1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL− 1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Biological Sciences Faculty of Sciences and Letters University of São Paulo State (UNESP)ThoMSon Mass Spectrometry Laboratory Institute of Chemistry University of Campinas (UNICAMP)Department of Botany Institute of Biosciences of Botucatu UNESP—Univ. Estadual PaulistaFaculty of Pharmaceutical Sciences University of Campinas (UNICAMP), P.O. Box 859CPQBA Microbiology Division University of Campinas, P.O. Box 6171Department of Biological Sciences Faculty of Sciences and Letters University of São Paulo State (UNESP)Department of Botany Institute of Biosciences of Botucatu UNESP—Univ. Estadual PaulistaFAPESP: 2017/15610-0Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Santos, Catarina dos [UNESP]Galaverna, Renan S.Angolini, Celio F. FNunes, Vania V. A. [UNESP]de Almeida, Luiz F. R. [UNESP]Ruiz, Ana L. T. G.de Carvalho, João EDuarte, Regina M. T.Duarte, Marta C. TEberlin, Marcos N2018-12-11T17:19:44Z2018-12-11T17:19:44Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/molecules23050986Molecules, v. 23, n. 5, 2018.1420-3049http://hdl.handle.net/11449/17624010.3390/molecules230509862-s2.0-850461026312-s2.0-85046102631.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecules0,855info:eu-repo/semantics/openAccess2023-12-21T06:22:26Zoai:repositorio.unesp.br:11449/176240Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:55:10.464928Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
title |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
spellingShingle |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species Santos, Catarina dos [UNESP] Biological activities ESI(−)Q-TOF-MS Myrcia spp. Phenolic compounds |
title_short |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
title_full |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
title_fullStr |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
title_full_unstemmed |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
title_sort |
Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three myrcia species |
author |
Santos, Catarina dos [UNESP] |
author_facet |
Santos, Catarina dos [UNESP] Galaverna, Renan S. Angolini, Celio F. F Nunes, Vania V. A. [UNESP] de Almeida, Luiz F. R. [UNESP] Ruiz, Ana L. T. G. de Carvalho, João E Duarte, Regina M. T. Duarte, Marta C. T Eberlin, Marcos N |
author_role |
author |
author2 |
Galaverna, Renan S. Angolini, Celio F. F Nunes, Vania V. A. [UNESP] de Almeida, Luiz F. R. [UNESP] Ruiz, Ana L. T. G. de Carvalho, João E Duarte, Regina M. T. Duarte, Marta C. T Eberlin, Marcos N |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Santos, Catarina dos [UNESP] Galaverna, Renan S. Angolini, Celio F. F Nunes, Vania V. A. [UNESP] de Almeida, Luiz F. R. [UNESP] Ruiz, Ana L. T. G. de Carvalho, João E Duarte, Regina M. T. Duarte, Marta C. T Eberlin, Marcos N |
dc.subject.por.fl_str_mv |
Biological activities ESI(−)Q-TOF-MS Myrcia spp. Phenolic compounds |
topic |
Biological activities ESI(−)Q-TOF-MS Myrcia spp. Phenolic compounds |
description |
Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL− 1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL− 1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL− 1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL− 1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:19:44Z 2018-12-11T17:19:44Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/molecules23050986 Molecules, v. 23, n. 5, 2018. 1420-3049 http://hdl.handle.net/11449/176240 10.3390/molecules23050986 2-s2.0-85046102631 2-s2.0-85046102631.pdf |
url |
http://dx.doi.org/10.3390/molecules23050986 http://hdl.handle.net/11449/176240 |
identifier_str_mv |
Molecules, v. 23, n. 5, 2018. 1420-3049 10.3390/molecules23050986 2-s2.0-85046102631 2-s2.0-85046102631.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecules 0,855 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129263491088384 |