Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2013/835081 http://hdl.handle.net/11449/75182 |
Resumo: | After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals. In this study, twenty-four actinobacteria strains isolated from workers of Trachymyrmex ants were evaluated for antifungal activity towards a variety of Candida species. Results revealed that seven strains inhibited the tested Candida species. Streptomyces sp. TD025 presented potent and broad spectrum of inhibition of Candida and was selected for the isolation of bioactive molecules. From liquid shake culture of this bacterium, we isolated the rare antimycin urauchimycins A and B. For the first time, these molecules were evaluated for antifungal activity against medically important Candida species. Both antimycins showed antifungal activity, especially urauchimycin B. This compound inhibited the growth of all Candida species tested, with minimum inhibitory concentration values equivalent to the antifungal nystatin. Our results concur with the predictions that the attine ant-microbe symbiosis may be a source of bioactive metabolites for biotechnology and medical applications. © 2013 Thais D. Mendes et al. |
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Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex antscitrininnystatinunclassified drugurauchimycin Aurauchimycin BActinobacteriaantantifungal activityCandidafungal strainnonhumannucleotide sequenceStreptomycesAfter decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals. In this study, twenty-four actinobacteria strains isolated from workers of Trachymyrmex ants were evaluated for antifungal activity towards a variety of Candida species. Results revealed that seven strains inhibited the tested Candida species. Streptomyces sp. TD025 presented potent and broad spectrum of inhibition of Candida and was selected for the isolation of bioactive molecules. From liquid shake culture of this bacterium, we isolated the rare antimycin urauchimycins A and B. For the first time, these molecules were evaluated for antifungal activity against medically important Candida species. Both antimycins showed antifungal activity, especially urauchimycin B. This compound inhibited the growth of all Candida species tested, with minimum inhibitory concentration values equivalent to the antifungal nystatin. Our results concur with the predictions that the attine ant-microbe symbiosis may be a source of bioactive metabolites for biotechnology and medical applications. © 2013 Thais D. Mendes et al.Center for the Study of Social Insects São Paulo State University (UNESP), 13506-900 Rio Claro, SPEMBRAPA Agroenergy, Parque Estação Biológica, 70770-901 Brasília, DFChemistry Departament Federal University of Espírito Santo (UFES), 29075-910 Vitória, ESChemistry Department Federal University of São Carlos (UFSCar), 18052-780 São Carlos, SPDepartment of Biochemistry and Microbiology São Paulo State University (UNESP), 13506-900 Rio Claro, SPDepartment of Ecology and Evolutionary Biology Rice University, Houston, TXDivision of Microbiology Center for Chemistry, Biology and Agriculture Research (CPQBA/UNICAMP), 13081-970 Paulínia, SPCenter for the Study of Social Insects São Paulo State University (UNESP), 13506-900 Rio Claro, SPDepartment of Biochemistry and Microbiology São Paulo State University (UNESP), 13506-900 Rio Claro, SPUniversidade Estadual Paulista (Unesp)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Federal do Espírito Santo (UFES)Universidade Federal de São Carlos (UFSCar)Rice UniversityUniversidade Estadual de Campinas (UNICAMP)Mendes, Thais D. [UNESP]Borges, Warley S.Rodrigues, Andre [UNESP]Solomon, Scott E.Vieira, Paulo C.Duarte, Marta C. T.Pagnocca, Fernando C. [UNESP]2014-05-27T11:29:00Z2014-05-27T11:29:00Z2013-04-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2013/835081BioMed Research International, v. 2013.2314-61332314-6141http://hdl.handle.net/11449/7518210.1155/2013/835081WOS:0003169017000012-s2.0-848765783262-s2.0-84876578326.pdf0000-0002-4164-9362Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International2.5830,9350,935info:eu-repo/semantics/openAccess2024-04-11T14:57:11Zoai:repositorio.unesp.br:11449/75182Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:10:15.546749Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
title |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
spellingShingle |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants Mendes, Thais D. [UNESP] citrinin nystatin unclassified drug urauchimycin A urauchimycin B Actinobacteria ant antifungal activity Candida fungal strain nonhuman nucleotide sequence Streptomyces |
title_short |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
title_full |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
title_fullStr |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
title_full_unstemmed |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
title_sort |
Anti-Candida properties of urauchimycins from actinobacteria associated with Trachymyrmex ants |
author |
Mendes, Thais D. [UNESP] |
author_facet |
Mendes, Thais D. [UNESP] Borges, Warley S. Rodrigues, Andre [UNESP] Solomon, Scott E. Vieira, Paulo C. Duarte, Marta C. T. Pagnocca, Fernando C. [UNESP] |
author_role |
author |
author2 |
Borges, Warley S. Rodrigues, Andre [UNESP] Solomon, Scott E. Vieira, Paulo C. Duarte, Marta C. T. Pagnocca, Fernando C. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Universidade Federal do Espírito Santo (UFES) Universidade Federal de São Carlos (UFSCar) Rice University Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Mendes, Thais D. [UNESP] Borges, Warley S. Rodrigues, Andre [UNESP] Solomon, Scott E. Vieira, Paulo C. Duarte, Marta C. T. Pagnocca, Fernando C. [UNESP] |
dc.subject.por.fl_str_mv |
citrinin nystatin unclassified drug urauchimycin A urauchimycin B Actinobacteria ant antifungal activity Candida fungal strain nonhuman nucleotide sequence Streptomyces |
topic |
citrinin nystatin unclassified drug urauchimycin A urauchimycin B Actinobacteria ant antifungal activity Candida fungal strain nonhuman nucleotide sequence Streptomyces |
description |
After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals. In this study, twenty-four actinobacteria strains isolated from workers of Trachymyrmex ants were evaluated for antifungal activity towards a variety of Candida species. Results revealed that seven strains inhibited the tested Candida species. Streptomyces sp. TD025 presented potent and broad spectrum of inhibition of Candida and was selected for the isolation of bioactive molecules. From liquid shake culture of this bacterium, we isolated the rare antimycin urauchimycins A and B. For the first time, these molecules were evaluated for antifungal activity against medically important Candida species. Both antimycins showed antifungal activity, especially urauchimycin B. This compound inhibited the growth of all Candida species tested, with minimum inhibitory concentration values equivalent to the antifungal nystatin. Our results concur with the predictions that the attine ant-microbe symbiosis may be a source of bioactive metabolites for biotechnology and medical applications. © 2013 Thais D. Mendes et al. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-29 2014-05-27T11:29:00Z 2014-05-27T11:29:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2013/835081 BioMed Research International, v. 2013. 2314-6133 2314-6141 http://hdl.handle.net/11449/75182 10.1155/2013/835081 WOS:000316901700001 2-s2.0-84876578326 2-s2.0-84876578326.pdf 0000-0002-4164-9362 |
url |
http://dx.doi.org/10.1155/2013/835081 http://hdl.handle.net/11449/75182 |
identifier_str_mv |
BioMed Research International, v. 2013. 2314-6133 2314-6141 10.1155/2013/835081 WOS:000316901700001 2-s2.0-84876578326 2-s2.0-84876578326.pdf 0000-0002-4164-9362 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BioMed Research International 2.583 0,935 0,935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128904328642560 |