Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1177/1040638717743280 http://hdl.handle.net/11449/170645 |
Resumo: | Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in dogs. We evaluated Ki67 immunoexpression and mitotic index (MI) in dogs diagnosed with DLBCL and treated with a 19-wk CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol. Twenty-nine lymph node samples from dogs diagnosed with DLBCL were analyzed for Ki67 immunostaining, and positive cells present in 1 cm2 were counted in a grid reticle for comparison of survival times above and below the means. The Ki67 mean was 107, and the MI mean was 21. There was a significant (p < 0.05) difference in median survival time between Ki67 immunostaining above and below the mean, with no difference in MI groups. Ki67 values >107 positive cells per 5 HPF counted in a grid reticle were associated with shorter survival times in dogs with DLBCL treated with a 19-wk CHOP-based protocol. |
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Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocolCell proliferationdogsimmunohistochemistrymitosisprognosisDiffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in dogs. We evaluated Ki67 immunoexpression and mitotic index (MI) in dogs diagnosed with DLBCL and treated with a 19-wk CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol. Twenty-nine lymph node samples from dogs diagnosed with DLBCL were analyzed for Ki67 immunostaining, and positive cells present in 1 cm2 were counted in a grid reticle for comparison of survival times above and below the means. The Ki67 mean was 107, and the MI mean was 21. There was a significant (p < 0.05) difference in median survival time between Ki67 immunostaining above and below the mean, with no difference in MI groups. Ki67 values >107 positive cells per 5 HPF counted in a grid reticle were associated with shorter survival times in dogs with DLBCL treated with a 19-wk CHOP-based protocol.Clinical Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)College of Veterinary Medicine Franca UniversityPathology Veterinary Department College of Veterinary and Zootechnical Medicine São Paulo State University Júlio de Mesquita FilhoVeterinary Laboratory VetPatPathology Department Federal Institute of Education Science and Technology of the South of Minas Gerais, Campus of MuzambinhoClinical Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)Pathology Veterinary Department College of Veterinary and Zootechnical Medicine São Paulo State University Júlio de Mesquita FilhoUniversidade Estadual Paulista (Unesp)Franca UniversityVeterinary Laboratory VetPatScience and Technology of the South of Minas GeraisSierra Matiz, Oscar R. [UNESP]Santilli, JulianaAnai, Leticia A. [UNESP]Da Silva, Maria C. L. [UNESP]Sueiro, Felipe A.Sequeira, Júlio L. [UNESP]Magalhães, Larissa F.Magalhães, Geórgia M.Tinucci Costa, Mirela [UNESP]Calazans, Sabryna G. [UNESP]2018-12-11T16:51:50Z2018-12-11T16:51:50Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article263-267application/pdfhttp://dx.doi.org/10.1177/1040638717743280Journal of Veterinary Diagnostic Investigation, v. 30, n. 2, p. 263-267, 2018.1943-49361040-6387http://hdl.handle.net/11449/17064510.1177/10406387177432802-s2.0-850417166522-s2.0-85041716652.pdf3409765424060945Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Veterinary Diagnostic Investigation0,621info:eu-repo/semantics/openAccess2023-12-03T06:11:10Zoai:repositorio.unesp.br:11449/170645Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:21:31.704604Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| title |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| spellingShingle |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol Sierra Matiz, Oscar R. [UNESP] Cell proliferation dogs immunohistochemistry mitosis prognosis |
| title_short |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| title_full |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| title_fullStr |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| title_full_unstemmed |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| title_sort |
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol |
| author |
Sierra Matiz, Oscar R. [UNESP] |
| author_facet |
Sierra Matiz, Oscar R. [UNESP] Santilli, Juliana Anai, Leticia A. [UNESP] Da Silva, Maria C. L. [UNESP] Sueiro, Felipe A. Sequeira, Júlio L. [UNESP] Magalhães, Larissa F. Magalhães, Geórgia M. Tinucci Costa, Mirela [UNESP] Calazans, Sabryna G. [UNESP] |
| author_role |
author |
| author2 |
Santilli, Juliana Anai, Leticia A. [UNESP] Da Silva, Maria C. L. [UNESP] Sueiro, Felipe A. Sequeira, Júlio L. [UNESP] Magalhães, Larissa F. Magalhães, Geórgia M. Tinucci Costa, Mirela [UNESP] Calazans, Sabryna G. [UNESP] |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Franca University Veterinary Laboratory VetPat Science and Technology of the South of Minas Gerais |
| dc.contributor.author.fl_str_mv |
Sierra Matiz, Oscar R. [UNESP] Santilli, Juliana Anai, Leticia A. [UNESP] Da Silva, Maria C. L. [UNESP] Sueiro, Felipe A. Sequeira, Júlio L. [UNESP] Magalhães, Larissa F. Magalhães, Geórgia M. Tinucci Costa, Mirela [UNESP] Calazans, Sabryna G. [UNESP] |
| dc.subject.por.fl_str_mv |
Cell proliferation dogs immunohistochemistry mitosis prognosis |
| topic |
Cell proliferation dogs immunohistochemistry mitosis prognosis |
| description |
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in dogs. We evaluated Ki67 immunoexpression and mitotic index (MI) in dogs diagnosed with DLBCL and treated with a 19-wk CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol. Twenty-nine lymph node samples from dogs diagnosed with DLBCL were analyzed for Ki67 immunostaining, and positive cells present in 1 cm2 were counted in a grid reticle for comparison of survival times above and below the means. The Ki67 mean was 107, and the MI mean was 21. There was a significant (p < 0.05) difference in median survival time between Ki67 immunostaining above and below the mean, with no difference in MI groups. Ki67 values >107 positive cells per 5 HPF counted in a grid reticle were associated with shorter survival times in dogs with DLBCL treated with a 19-wk CHOP-based protocol. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-12-11T16:51:50Z 2018-12-11T16:51:50Z 2018-03-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/1040638717743280 Journal of Veterinary Diagnostic Investigation, v. 30, n. 2, p. 263-267, 2018. 1943-4936 1040-6387 http://hdl.handle.net/11449/170645 10.1177/1040638717743280 2-s2.0-85041716652 2-s2.0-85041716652.pdf 3409765424060945 |
| url |
http://dx.doi.org/10.1177/1040638717743280 http://hdl.handle.net/11449/170645 |
| identifier_str_mv |
Journal of Veterinary Diagnostic Investigation, v. 30, n. 2, p. 263-267, 2018. 1943-4936 1040-6387 10.1177/1040638717743280 2-s2.0-85041716652 2-s2.0-85041716652.pdf 3409765424060945 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Veterinary Diagnostic Investigation 0,621 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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263-267 application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808129057313783808 |