Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface

Detalhes bibliográficos
Autor(a) principal: Alves, Sofia A.
Data de Publicação: 2017
Outros Autores: Patel, Sweetu B., Sukotjo, Cortino, Mathew, Mathew T., Filho, Paulo N. [UNESP], Celis, Jean-Pierre, Rocha, Luís A. [UNESP], Shokuhfar, Tolou
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.apsusc.2016.12.105
http://hdl.handle.net/11449/173982
Resumo: The modification of surface features such as nano-morphology/topography and chemistry have been employed in the attempt to design titanium oxide surfaces able to overcome the current dental implants failures. The main goal of this study is the synthesis of bone-like structured titanium dioxide (TiO2) nanotubes enriched with Calcium (Ca) and Phosphorous (P) able to enhance osteoblastic cell functions and, simultaneously, display an improved corrosion behavior. To achieve the main goal, TiO2 nanotubes were synthetized and doped with Ca and P by means of a novel methodology which relied, firstly, on the synthesis of TiO2 nanotubes by anodization of titanium in an organic electrolyte followed by reverse polarization and/or anodization, in an aqueous electrolyte. Results show that hydrophilic bone-like structured TiO2 nanotubes were successfully synthesized presenting a highly ordered nano-morphology characterized by non-uniform diameters. The chemical analysis of such nanotubes confirmed the presence of CaCO3, Ca3(PO4)2, CaHPO4 and CaO compounds. The nanotube surfaces submitted to reverse polarization, presented an improved cell adhesion and proliferation compared to smooth titanium. Furthermore, these surfaces displayed a significantly lower passive current in artificial saliva, and so, potential to minimize their bio-degradation through corrosion processes. This study addresses a very simple and promising multidisciplinary approach bringing new insights for the development of novel methodologies to improve the outcome of osseointegrated implants.
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spelling Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surfaceAnodizationBio-functionalizationCalcium-phosphorous surfaceOsseointegrated implantsReverse polarizationTiO2 nanotubesThe modification of surface features such as nano-morphology/topography and chemistry have been employed in the attempt to design titanium oxide surfaces able to overcome the current dental implants failures. The main goal of this study is the synthesis of bone-like structured titanium dioxide (TiO2) nanotubes enriched with Calcium (Ca) and Phosphorous (P) able to enhance osteoblastic cell functions and, simultaneously, display an improved corrosion behavior. To achieve the main goal, TiO2 nanotubes were synthetized and doped with Ca and P by means of a novel methodology which relied, firstly, on the synthesis of TiO2 nanotubes by anodization of titanium in an organic electrolyte followed by reverse polarization and/or anodization, in an aqueous electrolyte. Results show that hydrophilic bone-like structured TiO2 nanotubes were successfully synthesized presenting a highly ordered nano-morphology characterized by non-uniform diameters. The chemical analysis of such nanotubes confirmed the presence of CaCO3, Ca3(PO4)2, CaHPO4 and CaO compounds. The nanotube surfaces submitted to reverse polarization, presented an improved cell adhesion and proliferation compared to smooth titanium. Furthermore, these surfaces displayed a significantly lower passive current in artificial saliva, and so, potential to minimize their bio-degradation through corrosion processes. This study addresses a very simple and promising multidisciplinary approach bringing new insights for the development of novel methodologies to improve the outcome of osseointegrated implants.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CMEMS – Center of Micro Electro Mechanical Systems Department of Mechanical Engineering University of MinhoIBTN/US – American Branch of the Institute of Biomaterials, Tribocorrosion and NanomedicineDepartment of Mechanical Engineering Michigan Technological UniversityDepartmenmt of Restorative Dentistry University of Illinois at ChicagoDepartment of Orthopedic Surgery Rush University Medical CenterDepartment of Biomedical science UIC school of MedicineIBTN/Br – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine UNESP – Universidade Estadual Paulista Faculdade de Ciências Campus de BauruDepartment of Materials Engineering, KU LeuvenDepartment of Bioengineering University of Illinois at ChicagoFaculdade de Ciências Departamento de Física UNESP - Universidade Estadual PaulistaIBTN/Br – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine UNESP – Universidade Estadual Paulista Faculdade de Ciências Campus de BauruFaculdade de Ciências Departamento de Física UNESP - Universidade Estadual PaulistaUniversity of MinhoIBTN/US – American Branch of the Institute of BiomaterialsMichigan Technological UniversityUniversity of Illinois at ChicagoRush University Medical CenterUIC school of MedicineUniversidade Estadual Paulista (Unesp)Alves, Sofia A.Patel, Sweetu B.Sukotjo, CortinoMathew, Mathew T.Filho, Paulo N. [UNESP]Celis, Jean-PierreRocha, Luís A. [UNESP]Shokuhfar, Tolou2018-12-11T17:08:37Z2018-12-11T17:08:37Z2017-03-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article682-701application/pdfhttp://dx.doi.org/10.1016/j.apsusc.2016.12.105Applied Surface Science, v. 399, p. 682-701.0169-4332http://hdl.handle.net/11449/17398210.1016/j.apsusc.2016.12.1052-s2.0-850071747262-s2.0-85007174726.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengApplied Surface Science1,093info:eu-repo/semantics/openAccess2024-04-25T17:39:40Zoai:repositorio.unesp.br:11449/173982Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:34:08.866202Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
title Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
spellingShingle Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
Alves, Sofia A.
Anodization
Bio-functionalization
Calcium-phosphorous surface
Osseointegrated implants
Reverse polarization
TiO2 nanotubes
title_short Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
title_full Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
title_fullStr Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
title_full_unstemmed Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
title_sort Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
author Alves, Sofia A.
author_facet Alves, Sofia A.
Patel, Sweetu B.
Sukotjo, Cortino
Mathew, Mathew T.
Filho, Paulo N. [UNESP]
Celis, Jean-Pierre
Rocha, Luís A. [UNESP]
Shokuhfar, Tolou
author_role author
author2 Patel, Sweetu B.
Sukotjo, Cortino
Mathew, Mathew T.
Filho, Paulo N. [UNESP]
Celis, Jean-Pierre
Rocha, Luís A. [UNESP]
Shokuhfar, Tolou
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of Minho
IBTN/US – American Branch of the Institute of Biomaterials
Michigan Technological University
University of Illinois at Chicago
Rush University Medical Center
UIC school of Medicine
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Alves, Sofia A.
Patel, Sweetu B.
Sukotjo, Cortino
Mathew, Mathew T.
Filho, Paulo N. [UNESP]
Celis, Jean-Pierre
Rocha, Luís A. [UNESP]
Shokuhfar, Tolou
dc.subject.por.fl_str_mv Anodization
Bio-functionalization
Calcium-phosphorous surface
Osseointegrated implants
Reverse polarization
TiO2 nanotubes
topic Anodization
Bio-functionalization
Calcium-phosphorous surface
Osseointegrated implants
Reverse polarization
TiO2 nanotubes
description The modification of surface features such as nano-morphology/topography and chemistry have been employed in the attempt to design titanium oxide surfaces able to overcome the current dental implants failures. The main goal of this study is the synthesis of bone-like structured titanium dioxide (TiO2) nanotubes enriched with Calcium (Ca) and Phosphorous (P) able to enhance osteoblastic cell functions and, simultaneously, display an improved corrosion behavior. To achieve the main goal, TiO2 nanotubes were synthetized and doped with Ca and P by means of a novel methodology which relied, firstly, on the synthesis of TiO2 nanotubes by anodization of titanium in an organic electrolyte followed by reverse polarization and/or anodization, in an aqueous electrolyte. Results show that hydrophilic bone-like structured TiO2 nanotubes were successfully synthesized presenting a highly ordered nano-morphology characterized by non-uniform diameters. The chemical analysis of such nanotubes confirmed the presence of CaCO3, Ca3(PO4)2, CaHPO4 and CaO compounds. The nanotube surfaces submitted to reverse polarization, presented an improved cell adhesion and proliferation compared to smooth titanium. Furthermore, these surfaces displayed a significantly lower passive current in artificial saliva, and so, potential to minimize their bio-degradation through corrosion processes. This study addresses a very simple and promising multidisciplinary approach bringing new insights for the development of novel methodologies to improve the outcome of osseointegrated implants.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-31
2018-12-11T17:08:37Z
2018-12-11T17:08:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.apsusc.2016.12.105
Applied Surface Science, v. 399, p. 682-701.
0169-4332
http://hdl.handle.net/11449/173982
10.1016/j.apsusc.2016.12.105
2-s2.0-85007174726
2-s2.0-85007174726.pdf
url http://dx.doi.org/10.1016/j.apsusc.2016.12.105
http://hdl.handle.net/11449/173982
identifier_str_mv Applied Surface Science, v. 399, p. 682-701.
0169-4332
10.1016/j.apsusc.2016.12.105
2-s2.0-85007174726
2-s2.0-85007174726.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Applied Surface Science
1,093
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 682-701
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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