Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.apsusc.2016.12.105 http://hdl.handle.net/11449/173982 |
Resumo: | The modification of surface features such as nano-morphology/topography and chemistry have been employed in the attempt to design titanium oxide surfaces able to overcome the current dental implants failures. The main goal of this study is the synthesis of bone-like structured titanium dioxide (TiO2) nanotubes enriched with Calcium (Ca) and Phosphorous (P) able to enhance osteoblastic cell functions and, simultaneously, display an improved corrosion behavior. To achieve the main goal, TiO2 nanotubes were synthetized and doped with Ca and P by means of a novel methodology which relied, firstly, on the synthesis of TiO2 nanotubes by anodization of titanium in an organic electrolyte followed by reverse polarization and/or anodization, in an aqueous electrolyte. Results show that hydrophilic bone-like structured TiO2 nanotubes were successfully synthesized presenting a highly ordered nano-morphology characterized by non-uniform diameters. The chemical analysis of such nanotubes confirmed the presence of CaCO3, Ca3(PO4)2, CaHPO4 and CaO compounds. The nanotube surfaces submitted to reverse polarization, presented an improved cell adhesion and proliferation compared to smooth titanium. Furthermore, these surfaces displayed a significantly lower passive current in artificial saliva, and so, potential to minimize their bio-degradation through corrosion processes. This study addresses a very simple and promising multidisciplinary approach bringing new insights for the development of novel methodologies to improve the outcome of osseointegrated implants. |
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Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surfaceAnodizationBio-functionalizationCalcium-phosphorous surfaceOsseointegrated implantsReverse polarizationTiO2 nanotubesThe modification of surface features such as nano-morphology/topography and chemistry have been employed in the attempt to design titanium oxide surfaces able to overcome the current dental implants failures. The main goal of this study is the synthesis of bone-like structured titanium dioxide (TiO2) nanotubes enriched with Calcium (Ca) and Phosphorous (P) able to enhance osteoblastic cell functions and, simultaneously, display an improved corrosion behavior. To achieve the main goal, TiO2 nanotubes were synthetized and doped with Ca and P by means of a novel methodology which relied, firstly, on the synthesis of TiO2 nanotubes by anodization of titanium in an organic electrolyte followed by reverse polarization and/or anodization, in an aqueous electrolyte. Results show that hydrophilic bone-like structured TiO2 nanotubes were successfully synthesized presenting a highly ordered nano-morphology characterized by non-uniform diameters. The chemical analysis of such nanotubes confirmed the presence of CaCO3, Ca3(PO4)2, CaHPO4 and CaO compounds. The nanotube surfaces submitted to reverse polarization, presented an improved cell adhesion and proliferation compared to smooth titanium. Furthermore, these surfaces displayed a significantly lower passive current in artificial saliva, and so, potential to minimize their bio-degradation through corrosion processes. This study addresses a very simple and promising multidisciplinary approach bringing new insights for the development of novel methodologies to improve the outcome of osseointegrated implants.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CMEMS – Center of Micro Electro Mechanical Systems Department of Mechanical Engineering University of MinhoIBTN/US – American Branch of the Institute of Biomaterials, Tribocorrosion and NanomedicineDepartment of Mechanical Engineering Michigan Technological UniversityDepartmenmt of Restorative Dentistry University of Illinois at ChicagoDepartment of Orthopedic Surgery Rush University Medical CenterDepartment of Biomedical science UIC school of MedicineIBTN/Br – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine UNESP – Universidade Estadual Paulista Faculdade de Ciências Campus de BauruDepartment of Materials Engineering, KU LeuvenDepartment of Bioengineering University of Illinois at ChicagoFaculdade de Ciências Departamento de Física UNESP - Universidade Estadual PaulistaIBTN/Br – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine UNESP – Universidade Estadual Paulista Faculdade de Ciências Campus de BauruFaculdade de Ciências Departamento de Física UNESP - Universidade Estadual PaulistaUniversity of MinhoIBTN/US – American Branch of the Institute of BiomaterialsMichigan Technological UniversityUniversity of Illinois at ChicagoRush University Medical CenterUIC school of MedicineUniversidade Estadual Paulista (Unesp)Alves, Sofia A.Patel, Sweetu B.Sukotjo, CortinoMathew, Mathew T.Filho, Paulo N. [UNESP]Celis, Jean-PierreRocha, Luís A. [UNESP]Shokuhfar, Tolou2018-12-11T17:08:37Z2018-12-11T17:08:37Z2017-03-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article682-701application/pdfhttp://dx.doi.org/10.1016/j.apsusc.2016.12.105Applied Surface Science, v. 399, p. 682-701.0169-4332http://hdl.handle.net/11449/17398210.1016/j.apsusc.2016.12.1052-s2.0-850071747262-s2.0-85007174726.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengApplied Surface Science1,093info:eu-repo/semantics/openAccess2024-04-25T17:39:40Zoai:repositorio.unesp.br:11449/173982Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:34:08.866202Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
title |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
spellingShingle |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface Alves, Sofia A. Anodization Bio-functionalization Calcium-phosphorous surface Osseointegrated implants Reverse polarization TiO2 nanotubes |
title_short |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
title_full |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
title_fullStr |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
title_full_unstemmed |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
title_sort |
Synthesis of calcium-phosphorous doped TiO2 nanotubes by anodization and reverse polarization: A promising strategy for an efficient biofunctional implant surface |
author |
Alves, Sofia A. |
author_facet |
Alves, Sofia A. Patel, Sweetu B. Sukotjo, Cortino Mathew, Mathew T. Filho, Paulo N. [UNESP] Celis, Jean-Pierre Rocha, Luís A. [UNESP] Shokuhfar, Tolou |
author_role |
author |
author2 |
Patel, Sweetu B. Sukotjo, Cortino Mathew, Mathew T. Filho, Paulo N. [UNESP] Celis, Jean-Pierre Rocha, Luís A. [UNESP] Shokuhfar, Tolou |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Minho IBTN/US – American Branch of the Institute of Biomaterials Michigan Technological University University of Illinois at Chicago Rush University Medical Center UIC school of Medicine Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alves, Sofia A. Patel, Sweetu B. Sukotjo, Cortino Mathew, Mathew T. Filho, Paulo N. [UNESP] Celis, Jean-Pierre Rocha, Luís A. [UNESP] Shokuhfar, Tolou |
dc.subject.por.fl_str_mv |
Anodization Bio-functionalization Calcium-phosphorous surface Osseointegrated implants Reverse polarization TiO2 nanotubes |
topic |
Anodization Bio-functionalization Calcium-phosphorous surface Osseointegrated implants Reverse polarization TiO2 nanotubes |
description |
The modification of surface features such as nano-morphology/topography and chemistry have been employed in the attempt to design titanium oxide surfaces able to overcome the current dental implants failures. The main goal of this study is the synthesis of bone-like structured titanium dioxide (TiO2) nanotubes enriched with Calcium (Ca) and Phosphorous (P) able to enhance osteoblastic cell functions and, simultaneously, display an improved corrosion behavior. To achieve the main goal, TiO2 nanotubes were synthetized and doped with Ca and P by means of a novel methodology which relied, firstly, on the synthesis of TiO2 nanotubes by anodization of titanium in an organic electrolyte followed by reverse polarization and/or anodization, in an aqueous electrolyte. Results show that hydrophilic bone-like structured TiO2 nanotubes were successfully synthesized presenting a highly ordered nano-morphology characterized by non-uniform diameters. The chemical analysis of such nanotubes confirmed the presence of CaCO3, Ca3(PO4)2, CaHPO4 and CaO compounds. The nanotube surfaces submitted to reverse polarization, presented an improved cell adhesion and proliferation compared to smooth titanium. Furthermore, these surfaces displayed a significantly lower passive current in artificial saliva, and so, potential to minimize their bio-degradation through corrosion processes. This study addresses a very simple and promising multidisciplinary approach bringing new insights for the development of novel methodologies to improve the outcome of osseointegrated implants. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-31 2018-12-11T17:08:37Z 2018-12-11T17:08:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.apsusc.2016.12.105 Applied Surface Science, v. 399, p. 682-701. 0169-4332 http://hdl.handle.net/11449/173982 10.1016/j.apsusc.2016.12.105 2-s2.0-85007174726 2-s2.0-85007174726.pdf |
url |
http://dx.doi.org/10.1016/j.apsusc.2016.12.105 http://hdl.handle.net/11449/173982 |
identifier_str_mv |
Applied Surface Science, v. 399, p. 682-701. 0169-4332 10.1016/j.apsusc.2016.12.105 2-s2.0-85007174726 2-s2.0-85007174726.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Applied Surface Science 1,093 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
682-701 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128672139313152 |