A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.surfcoat.2017.05.073 http://hdl.handle.net/11449/174677 |
Resumo: | The decoration of titanium (Ti) implant surfaces with TiO2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO2 nanotubes and their influence on the interfacial features of the films. TiO2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants. |
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A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodizationAnodizationInterfaceOsseointegrated implantsReverse polarizationTiO2 nanotubesThe decoration of titanium (Ti) implant surfaces with TiO2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO2 nanotubes and their influence on the interfacial features of the films. TiO2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CMEMS – Center of MicroElectroMechanical Systems Department of Mechanical Engineering University of Minho, AzurémIBTN/BR – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine Faculty of Sciences UNESP – Universidade Estadual PaulistaBrazilian Center for Research in PhysicsDirectory of Life Sciences Applied Metrology National Institute of Metrology Quality and TechnologyPostgraduate Program in Translational Biomedicine University of Grande RioInstitute of Biomedical Sciences UFRJ – Federal University of Rio de JaneiroDepartment of Materials Engineering KU LeuvenFaculdade de Ciências Departamento de Física UNESP – Universidade Estadual PaulistaDepartment of Bioengineering University of Illinois at ChicagoIBTN/US – American Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine University of Illinois at ChicagoIBTN/BR – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine Faculty of Sciences UNESP – Universidade Estadual PaulistaFaculdade de Ciências Departamento de Física UNESP – Universidade Estadual PaulistaCNPq: 490761/2013-5CAPES: 99999.008666/2014-08University of MinhoUniversidade Estadual Paulista (Unesp)Brazilian Center for Research in PhysicsQuality and TechnologyUniversity of Grande RioUniversidade Federal do Rio de Janeiro (UFRJ)KU LeuvenUniversity of Illinois at ChicagoAlves, Sofia A. [UNESP]Rossi, André L.Ribeiro, Ana R. [UNESP]Werckmann, Jacques [UNESP]Celis, Jean-PierreRocha, Luís A. [UNESP]Shokuhfar, Tolou2018-12-11T17:12:23Z2018-12-11T17:12:23Z2017-09-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article153-166application/pdfhttp://dx.doi.org/10.1016/j.surfcoat.2017.05.073Surface and Coatings Technology, v. 324, p. 153-166.0257-8972http://hdl.handle.net/11449/17467710.1016/j.surfcoat.2017.05.0732-s2.0-850199837662-s2.0-85019983766.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSurface and Coatings Technology0,928info:eu-repo/semantics/openAccess2024-04-25T17:40:20Zoai:repositorio.unesp.br:11449/174677Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:08:32.031323Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
title |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
spellingShingle |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization Alves, Sofia A. [UNESP] Anodization Interface Osseointegrated implants Reverse polarization TiO2 nanotubes |
title_short |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
title_full |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
title_fullStr |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
title_full_unstemmed |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
title_sort |
A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization |
author |
Alves, Sofia A. [UNESP] |
author_facet |
Alves, Sofia A. [UNESP] Rossi, André L. Ribeiro, Ana R. [UNESP] Werckmann, Jacques [UNESP] Celis, Jean-Pierre Rocha, Luís A. [UNESP] Shokuhfar, Tolou |
author_role |
author |
author2 |
Rossi, André L. Ribeiro, Ana R. [UNESP] Werckmann, Jacques [UNESP] Celis, Jean-Pierre Rocha, Luís A. [UNESP] Shokuhfar, Tolou |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
University of Minho Universidade Estadual Paulista (Unesp) Brazilian Center for Research in Physics Quality and Technology University of Grande Rio Universidade Federal do Rio de Janeiro (UFRJ) KU Leuven University of Illinois at Chicago |
dc.contributor.author.fl_str_mv |
Alves, Sofia A. [UNESP] Rossi, André L. Ribeiro, Ana R. [UNESP] Werckmann, Jacques [UNESP] Celis, Jean-Pierre Rocha, Luís A. [UNESP] Shokuhfar, Tolou |
dc.subject.por.fl_str_mv |
Anodization Interface Osseointegrated implants Reverse polarization TiO2 nanotubes |
topic |
Anodization Interface Osseointegrated implants Reverse polarization TiO2 nanotubes |
description |
The decoration of titanium (Ti) implant surfaces with TiO2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO2 nanotubes and their influence on the interfacial features of the films. TiO2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-15 2018-12-11T17:12:23Z 2018-12-11T17:12:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.surfcoat.2017.05.073 Surface and Coatings Technology, v. 324, p. 153-166. 0257-8972 http://hdl.handle.net/11449/174677 10.1016/j.surfcoat.2017.05.073 2-s2.0-85019983766 2-s2.0-85019983766.pdf |
url |
http://dx.doi.org/10.1016/j.surfcoat.2017.05.073 http://hdl.handle.net/11449/174677 |
identifier_str_mv |
Surface and Coatings Technology, v. 324, p. 153-166. 0257-8972 10.1016/j.surfcoat.2017.05.073 2-s2.0-85019983766 2-s2.0-85019983766.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Surface and Coatings Technology 0,928 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
153-166 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129396663386112 |