A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization

Detalhes bibliográficos
Autor(a) principal: Alves, Sofia A. [UNESP]
Data de Publicação: 2017
Outros Autores: Rossi, André L., Ribeiro, Ana R. [UNESP], Werckmann, Jacques [UNESP], Celis, Jean-Pierre, Rocha, Luís A. [UNESP], Shokuhfar, Tolou
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.surfcoat.2017.05.073
http://hdl.handle.net/11449/174677
Resumo: The decoration of titanium (Ti) implant surfaces with TiO2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO2 nanotubes and their influence on the interfacial features of the films. TiO2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants.
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spelling A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodizationAnodizationInterfaceOsseointegrated implantsReverse polarizationTiO2 nanotubesThe decoration of titanium (Ti) implant surfaces with TiO2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO2 nanotubes and their influence on the interfacial features of the films. TiO2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CMEMS – Center of MicroElectroMechanical Systems Department of Mechanical Engineering University of Minho, AzurémIBTN/BR – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine Faculty of Sciences UNESP – Universidade Estadual PaulistaBrazilian Center for Research in PhysicsDirectory of Life Sciences Applied Metrology National Institute of Metrology Quality and TechnologyPostgraduate Program in Translational Biomedicine University of Grande RioInstitute of Biomedical Sciences UFRJ – Federal University of Rio de JaneiroDepartment of Materials Engineering KU LeuvenFaculdade de Ciências Departamento de Física UNESP – Universidade Estadual PaulistaDepartment of Bioengineering University of Illinois at ChicagoIBTN/US – American Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine University of Illinois at ChicagoIBTN/BR – Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine Faculty of Sciences UNESP – Universidade Estadual PaulistaFaculdade de Ciências Departamento de Física UNESP – Universidade Estadual PaulistaCNPq: 490761/2013-5CAPES: 99999.008666/2014-08University of MinhoUniversidade Estadual Paulista (Unesp)Brazilian Center for Research in PhysicsQuality and TechnologyUniversity of Grande RioUniversidade Federal do Rio de Janeiro (UFRJ)KU LeuvenUniversity of Illinois at ChicagoAlves, Sofia A. [UNESP]Rossi, André L.Ribeiro, Ana R. [UNESP]Werckmann, Jacques [UNESP]Celis, Jean-PierreRocha, Luís A. [UNESP]Shokuhfar, Tolou2018-12-11T17:12:23Z2018-12-11T17:12:23Z2017-09-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article153-166application/pdfhttp://dx.doi.org/10.1016/j.surfcoat.2017.05.073Surface and Coatings Technology, v. 324, p. 153-166.0257-8972http://hdl.handle.net/11449/17467710.1016/j.surfcoat.2017.05.0732-s2.0-850199837662-s2.0-85019983766.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSurface and Coatings Technology0,928info:eu-repo/semantics/openAccess2024-04-25T17:40:20Zoai:repositorio.unesp.br:11449/174677Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:08:32.031323Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
title A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
spellingShingle A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
Alves, Sofia A. [UNESP]
Anodization
Interface
Osseointegrated implants
Reverse polarization
TiO2 nanotubes
title_short A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
title_full A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
title_fullStr A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
title_full_unstemmed A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
title_sort A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization
author Alves, Sofia A. [UNESP]
author_facet Alves, Sofia A. [UNESP]
Rossi, André L.
Ribeiro, Ana R. [UNESP]
Werckmann, Jacques [UNESP]
Celis, Jean-Pierre
Rocha, Luís A. [UNESP]
Shokuhfar, Tolou
author_role author
author2 Rossi, André L.
Ribeiro, Ana R. [UNESP]
Werckmann, Jacques [UNESP]
Celis, Jean-Pierre
Rocha, Luís A. [UNESP]
Shokuhfar, Tolou
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of Minho
Universidade Estadual Paulista (Unesp)
Brazilian Center for Research in Physics
Quality and Technology
University of Grande Rio
Universidade Federal do Rio de Janeiro (UFRJ)
KU Leuven
University of Illinois at Chicago
dc.contributor.author.fl_str_mv Alves, Sofia A. [UNESP]
Rossi, André L.
Ribeiro, Ana R. [UNESP]
Werckmann, Jacques [UNESP]
Celis, Jean-Pierre
Rocha, Luís A. [UNESP]
Shokuhfar, Tolou
dc.subject.por.fl_str_mv Anodization
Interface
Osseointegrated implants
Reverse polarization
TiO2 nanotubes
topic Anodization
Interface
Osseointegrated implants
Reverse polarization
TiO2 nanotubes
description The decoration of titanium (Ti) implant surfaces with TiO2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO2 nanotubes and their influence on the interfacial features of the films. TiO2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-15
2018-12-11T17:12:23Z
2018-12-11T17:12:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.surfcoat.2017.05.073
Surface and Coatings Technology, v. 324, p. 153-166.
0257-8972
http://hdl.handle.net/11449/174677
10.1016/j.surfcoat.2017.05.073
2-s2.0-85019983766
2-s2.0-85019983766.pdf
url http://dx.doi.org/10.1016/j.surfcoat.2017.05.073
http://hdl.handle.net/11449/174677
identifier_str_mv Surface and Coatings Technology, v. 324, p. 153-166.
0257-8972
10.1016/j.surfcoat.2017.05.073
2-s2.0-85019983766
2-s2.0-85019983766.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Surface and Coatings Technology
0,928
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 153-166
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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