Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1477-7827-10-22 http://hdl.handle.net/11449/18739 |
Resumo: | Background: Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also used for the treatments of psychiatric disorders and neuropathic pain. The CBZ utilization has been associated with male reproductive damage, including hormonal alterations, sexual dysfunction and reduction of sperm quality. The wide and long-term use of the CBZ is a common schedule in children and adolescents and alters the testosterone level in adult rats and humans. The objective of this work was to evaluate the CBZ side effects on the ventral prostate of rats from pre-puberty to sexual maturation, since the prostate is an androgen-dependent organ.Methods: Twenty three day-old male albino Wistar rats received CBZ diluted in propylene glycol (20 mg/Kg/i.p via). The treatment lasted 20, 40 and 70 days, according to the different stages of the rat sexual maturation. At the end of each treatment period, ventral prostates were removed and histologically processed. The prostate sections were submitted to the histopathological, morphological and stereological analyses using image analysis system.Results: Reductions of the glandular epithelium, glandular lumen and fibromuscular stroma volume of the ventral prostate were observed in adult rats treated with CBZ since the weaning. Triggering and degranulation of mast cells were observed in the fibromuscular stroma of prepubertal and pubertal CBZ treated rats.Conclusions: The results suggest a direct effect of the CBZ on rat ventral prostate, evidenced by increase of mast cell and macrophage populations during pre-puberty and puberty causing a ventral prostate accentuated damage in the adult phase. |
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Repositório Institucional da UNESP |
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Harmful effects of carbamazepine on the postnatal development of the rat ventral prostateCarbamazepineVentral prostateMast cellsStereologyBackground: Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also used for the treatments of psychiatric disorders and neuropathic pain. The CBZ utilization has been associated with male reproductive damage, including hormonal alterations, sexual dysfunction and reduction of sperm quality. The wide and long-term use of the CBZ is a common schedule in children and adolescents and alters the testosterone level in adult rats and humans. The objective of this work was to evaluate the CBZ side effects on the ventral prostate of rats from pre-puberty to sexual maturation, since the prostate is an androgen-dependent organ.Methods: Twenty three day-old male albino Wistar rats received CBZ diluted in propylene glycol (20 mg/Kg/i.p via). The treatment lasted 20, 40 and 70 days, according to the different stages of the rat sexual maturation. At the end of each treatment period, ventral prostates were removed and histologically processed. The prostate sections were submitted to the histopathological, morphological and stereological analyses using image analysis system.Results: Reductions of the glandular epithelium, glandular lumen and fibromuscular stroma volume of the ventral prostate were observed in adult rats treated with CBZ since the weaning. Triggering and degranulation of mast cells were observed in the fibromuscular stroma of prepubertal and pubertal CBZ treated rats.Conclusions: The results suggest a direct effect of the CBZ on rat ventral prostate, evidenced by increase of mast cell and macrophage populations during pre-puberty and puberty causing a ventral prostate accentuated damage in the adult phase.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State Univ UNESP, Dept Morphol, Botucatu, SP, BrazilFed Univ São Paulo UNIFESP, Dev Biol Lab, Dept Morphol & Genet, São Paulo, BrazilSão Paulo State Univ UNESP, Dept Morphol, Botucatu, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Oliva, Samara U.Scarano, Wellerson R. [UNESP]Okada, Fatima K.Miraglia, Sandra M.2014-05-20T13:52:27Z2014-05-20T13:52:27Z2012-03-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://dx.doi.org/10.1186/1477-7827-10-22Reproductive Biology and Endocrinology. London: Biomed Central Ltd., v. 10, p. 15, 2012.1477-7827http://hdl.handle.net/11449/1873910.1186/1477-7827-10-22WOS:000303869100001WOS000303869100001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Biology and Endocrinology2.8521,203info:eu-repo/semantics/openAccess2023-10-26T06:11:18Zoai:repositorio.unesp.br:11449/18739Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:03:06.423134Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
spellingShingle |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate Oliva, Samara U. Carbamazepine Ventral prostate Mast cells Stereology |
title_short |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_full |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_fullStr |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_full_unstemmed |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_sort |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
author |
Oliva, Samara U. |
author_facet |
Oliva, Samara U. Scarano, Wellerson R. [UNESP] Okada, Fatima K. Miraglia, Sandra M. |
author_role |
author |
author2 |
Scarano, Wellerson R. [UNESP] Okada, Fatima K. Miraglia, Sandra M. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Oliva, Samara U. Scarano, Wellerson R. [UNESP] Okada, Fatima K. Miraglia, Sandra M. |
dc.subject.por.fl_str_mv |
Carbamazepine Ventral prostate Mast cells Stereology |
topic |
Carbamazepine Ventral prostate Mast cells Stereology |
description |
Background: Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also used for the treatments of psychiatric disorders and neuropathic pain. The CBZ utilization has been associated with male reproductive damage, including hormonal alterations, sexual dysfunction and reduction of sperm quality. The wide and long-term use of the CBZ is a common schedule in children and adolescents and alters the testosterone level in adult rats and humans. The objective of this work was to evaluate the CBZ side effects on the ventral prostate of rats from pre-puberty to sexual maturation, since the prostate is an androgen-dependent organ.Methods: Twenty three day-old male albino Wistar rats received CBZ diluted in propylene glycol (20 mg/Kg/i.p via). The treatment lasted 20, 40 and 70 days, according to the different stages of the rat sexual maturation. At the end of each treatment period, ventral prostates were removed and histologically processed. The prostate sections were submitted to the histopathological, morphological and stereological analyses using image analysis system.Results: Reductions of the glandular epithelium, glandular lumen and fibromuscular stroma volume of the ventral prostate were observed in adult rats treated with CBZ since the weaning. Triggering and degranulation of mast cells were observed in the fibromuscular stroma of prepubertal and pubertal CBZ treated rats.Conclusions: The results suggest a direct effect of the CBZ on rat ventral prostate, evidenced by increase of mast cell and macrophage populations during pre-puberty and puberty causing a ventral prostate accentuated damage in the adult phase. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03-25 2014-05-20T13:52:27Z 2014-05-20T13:52:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1477-7827-10-22 Reproductive Biology and Endocrinology. London: Biomed Central Ltd., v. 10, p. 15, 2012. 1477-7827 http://hdl.handle.net/11449/18739 10.1186/1477-7827-10-22 WOS:000303869100001 WOS000303869100001.pdf |
url |
http://dx.doi.org/10.1186/1477-7827-10-22 http://hdl.handle.net/11449/18739 |
identifier_str_mv |
Reproductive Biology and Endocrinology. London: Biomed Central Ltd., v. 10, p. 15, 2012. 1477-7827 10.1186/1477-7827-10-22 WOS:000303869100001 WOS000303869100001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reproductive Biology and Endocrinology 2.852 1,203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128600563515392 |