Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/796565 http://hdl.handle.net/11449/117241 |
Resumo: | Type 2 diabetes and obesity are increasing worldwide and linked to periodontitis, a chronic disease which is characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium. The mechanisms underlying the association of diabetes mellitus and obesity with periodontal destruction and compromised periodontal healing are not well understood, but decreased plasma levels of adiponectin, as found in diabetic and obese individuals, might be a critical mechanistic link. The aim of this in vitro study was to examine the effects of adiponectin on periodontal ligament (PDL) cells under normal and regenerative conditions, and to study the regulation of adiponectin and its receptors in these cells. Adiponectin stimulated significantly the expression of growth factors and extracellular matrix, proliferation, and in vitro wound healing, reduced significantly the constitutive tumor necrosis factor-alpha expression, and caused a significant upregulation of its own expression. The beneficial actions of enamel matrix derivative on a number of PDL cell functions critical for periodontal regeneration were partially enhanced by adiponectin. The periodontopathogen Porphyromonas gingivalis inhibited the adiponectin expression and stimulated the expression of its receptors. In conclusion, reduced levels of adiponectin, as found in type 2 diabetes and obesity, may compromise periodontal health and healing. |
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Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative ConditionsType 2 diabetes and obesity are increasing worldwide and linked to periodontitis, a chronic disease which is characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium. The mechanisms underlying the association of diabetes mellitus and obesity with periodontal destruction and compromised periodontal healing are not well understood, but decreased plasma levels of adiponectin, as found in diabetic and obese individuals, might be a critical mechanistic link. The aim of this in vitro study was to examine the effects of adiponectin on periodontal ligament (PDL) cells under normal and regenerative conditions, and to study the regulation of adiponectin and its receptors in these cells. Adiponectin stimulated significantly the expression of growth factors and extracellular matrix, proliferation, and in vitro wound healing, reduced significantly the constitutive tumor necrosis factor-alpha expression, and caused a significant upregulation of its own expression. The beneficial actions of enamel matrix derivative on a number of PDL cell functions critical for periodontal regeneration were partially enhanced by adiponectin. The periodontopathogen Porphyromonas gingivalis inhibited the adiponectin expression and stimulated the expression of its receptors. In conclusion, reduced levels of adiponectin, as found in type 2 diabetes and obesity, may compromise periodontal health and healing.German Research Foundation (Clinical Research Unit)Medical Faculty of the University of BonnUniv Bonn, D-53111 Bonn, GermanyUniv Bonn, Clin Res Unit 208, D-53111 Bonn, GermanyUNESP, Sch Dent, Dept Diag & Surg, BR-14801903 Araraquara, SP, BrazilUniv Bonn, Dept Periodontol Operat & Prevent Dent, D-53111 Bonn, GermanyUniv Bonn, Dept Orthodont, D-53111 Bonn, GermanyUniv Bern, Dept Periodontol, Lab Oral Microbiol, CH-3010 Bern, SwitzerlandUNESP, Sch Dent, Dept Diag & Surg, BR-14801903 Araraquara, SP, BrazilGerman Research Foundation (Clinical Research Unit)208/TP4Hindawi Publishing CorporationUniv BonnUniversidade Estadual Paulista (Unesp)Univ BernNokhbehsaim, MarjanKeser, SemaNogueira, Andressa Vilas Boas [UNESP]Cirelli, Joni Augusto [UNESP]Jepsen, SorenJaeger, AndreasEick, SigrunDeschner, James2015-03-18T15:55:37Z2015-03-18T15:55:37Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/epub+zipapplication/pdfhttp://dx.doi.org/10.1155/2014/796565Journal Of Diabetes Research. New York: Hindawi Publishing Corporation, 11 p., 2014.2314-6745http://hdl.handle.net/11449/11724110.1155/2014/796565WOS:000339752700001WOS000339752700001.pdfWOS000339752700001.epub2628593693450121Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Diabetes Research2.8851,116info:eu-repo/semantics/openAccess2024-01-11T06:31:27Zoai:repositorio.unesp.br:11449/117241Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:43:20.171511Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
title |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
spellingShingle |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions Nokhbehsaim, Marjan |
title_short |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
title_full |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
title_fullStr |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
title_full_unstemmed |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
title_sort |
Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions |
author |
Nokhbehsaim, Marjan |
author_facet |
Nokhbehsaim, Marjan Keser, Sema Nogueira, Andressa Vilas Boas [UNESP] Cirelli, Joni Augusto [UNESP] Jepsen, Soren Jaeger, Andreas Eick, Sigrun Deschner, James |
author_role |
author |
author2 |
Keser, Sema Nogueira, Andressa Vilas Boas [UNESP] Cirelli, Joni Augusto [UNESP] Jepsen, Soren Jaeger, Andreas Eick, Sigrun Deschner, James |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Bonn Universidade Estadual Paulista (Unesp) Univ Bern |
dc.contributor.author.fl_str_mv |
Nokhbehsaim, Marjan Keser, Sema Nogueira, Andressa Vilas Boas [UNESP] Cirelli, Joni Augusto [UNESP] Jepsen, Soren Jaeger, Andreas Eick, Sigrun Deschner, James |
description |
Type 2 diabetes and obesity are increasing worldwide and linked to periodontitis, a chronic disease which is characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium. The mechanisms underlying the association of diabetes mellitus and obesity with periodontal destruction and compromised periodontal healing are not well understood, but decreased plasma levels of adiponectin, as found in diabetic and obese individuals, might be a critical mechanistic link. The aim of this in vitro study was to examine the effects of adiponectin on periodontal ligament (PDL) cells under normal and regenerative conditions, and to study the regulation of adiponectin and its receptors in these cells. Adiponectin stimulated significantly the expression of growth factors and extracellular matrix, proliferation, and in vitro wound healing, reduced significantly the constitutive tumor necrosis factor-alpha expression, and caused a significant upregulation of its own expression. The beneficial actions of enamel matrix derivative on a number of PDL cell functions critical for periodontal regeneration were partially enhanced by adiponectin. The periodontopathogen Porphyromonas gingivalis inhibited the adiponectin expression and stimulated the expression of its receptors. In conclusion, reduced levels of adiponectin, as found in type 2 diabetes and obesity, may compromise periodontal health and healing. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2015-03-18T15:55:37Z 2015-03-18T15:55:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/796565 Journal Of Diabetes Research. New York: Hindawi Publishing Corporation, 11 p., 2014. 2314-6745 http://hdl.handle.net/11449/117241 10.1155/2014/796565 WOS:000339752700001 WOS000339752700001.pdf WOS000339752700001.epub 2628593693450121 |
url |
http://dx.doi.org/10.1155/2014/796565 http://hdl.handle.net/11449/117241 |
identifier_str_mv |
Journal Of Diabetes Research. New York: Hindawi Publishing Corporation, 11 p., 2014. 2314-6745 10.1155/2014/796565 WOS:000339752700001 WOS000339752700001.pdf WOS000339752700001.epub 2628593693450121 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Diabetes Research 2.885 1,116 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 application/epub+zip application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129454702067712 |