Fetal membranes: Potential source of preterm birth biomarkers
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Capítulo de livro |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-94-007-7696-8_28 http://hdl.handle.net/11449/228113 |
Resumo: | Preterm birth (birth before 37 weeks of complete gestation) is a major pregnancy complication and is the second largest cause of neonatal mortality worldwide. Majority of the preterm births are due to unknown etiologies, and this class of preterm births is known as spontaneous preterm birth (PTB). There are no reliable biomarkers to predict PTB as its causality and pathophysiologic pathways are unclear. Various maternal and fetal intrauterine compartments produce biomarkers that are associated with PTB. However, screening and diagnosis of PTB is difficult due to the overlap between various pathologic events associated with PTB and heterogeneity in biomarker response. Several studies have contributed to our current understanding of the mechanistic role of biomarkers produced by maternal and fetal tissues, but none of them have emerged as diagnostic tools. This chapter reviews knowledge gaps in PTB biomarker literature and discusses some of the fundamental issues associated with biomarker research in PTB. This discussion is based on data generated using human fetal membranes. Fetal membranes (amniochorionic membranes) are fetally derived tissues and forms the innermost lining of the intra-amniotic cavity. They provide structural integrity to the intrauterine cavity and are capable of responding to various maternal-fetal physiologic and pathophysiologic signals. Reports document hundreds of biomarkers produced by fetal membranes that are associated with various pregnancy complications. However, fetal membrane biomarker response is complex, and the diversity in their response makes it difficult to understand the pathways of PTB. This chapter reviews three distinct scenarios where fetal membrane biomarker signature can vary: (1) type of antigen, (2) type of risk exposure, and (3) the race/ethnicity of the subject from which the membranes are derived. This is to highlight the heterogeneity in fetal membrane biomarkers and demonstrate how pathways can be different based on distinct biomarker signature. Understanding both maternal and fetal biomarker response based on an individual's own risk profile is needed to tailor interventions to reduce the risk of PTB. |
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Fetal membranes: Potential source of preterm birth biomarkersPreterm birth (birth before 37 weeks of complete gestation) is a major pregnancy complication and is the second largest cause of neonatal mortality worldwide. Majority of the preterm births are due to unknown etiologies, and this class of preterm births is known as spontaneous preterm birth (PTB). There are no reliable biomarkers to predict PTB as its causality and pathophysiologic pathways are unclear. Various maternal and fetal intrauterine compartments produce biomarkers that are associated with PTB. However, screening and diagnosis of PTB is difficult due to the overlap between various pathologic events associated with PTB and heterogeneity in biomarker response. Several studies have contributed to our current understanding of the mechanistic role of biomarkers produced by maternal and fetal tissues, but none of them have emerged as diagnostic tools. This chapter reviews knowledge gaps in PTB biomarker literature and discusses some of the fundamental issues associated with biomarker research in PTB. This discussion is based on data generated using human fetal membranes. Fetal membranes (amniochorionic membranes) are fetally derived tissues and forms the innermost lining of the intra-amniotic cavity. They provide structural integrity to the intrauterine cavity and are capable of responding to various maternal-fetal physiologic and pathophysiologic signals. Reports document hundreds of biomarkers produced by fetal membranes that are associated with various pregnancy complications. However, fetal membrane biomarker response is complex, and the diversity in their response makes it difficult to understand the pathways of PTB. This chapter reviews three distinct scenarios where fetal membrane biomarker signature can vary: (1) type of antigen, (2) type of risk exposure, and (3) the race/ethnicity of the subject from which the membranes are derived. This is to highlight the heterogeneity in fetal membrane biomarkers and demonstrate how pathways can be different based on distinct biomarker signature. Understanding both maternal and fetal biomarker response based on an individual's own risk profile is needed to tailor interventions to reduce the risk of PTB.Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine Perinatal Research The University of Texas Medical Branch at GalvestonDepartment of Pathology Botucatu Medical School University Estadual PaulistaThe University of Texas Medical BranchDepartment of Pathology Botucatu Medical School University Estadual PaulistaThe University of Texas Medical Branch at GalvestonUniversidade Estadual Paulista (UNESP)The University of Texas Medical BranchMenon, RamkumarNicolau, Nathalia Noda [UNESP]Bredson, SarahPolettini, Jossimara2022-04-29T07:28:36Z2022-04-29T07:28:36Z2015-09-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart483-529http://dx.doi.org/10.1007/978-94-007-7696-8_28General Methods in Biomarker Research and their Applications, v. 1-2, p. 483-529.http://hdl.handle.net/11449/22811310.1007/978-94-007-7696-8_282-s2.0-84958696171Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGeneral Methods in Biomarker Research and their Applicationsinfo:eu-repo/semantics/openAccess2024-09-03T13:18:45Zoai:repositorio.unesp.br:11449/228113Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fetal membranes: Potential source of preterm birth biomarkers |
title |
Fetal membranes: Potential source of preterm birth biomarkers |
spellingShingle |
Fetal membranes: Potential source of preterm birth biomarkers Menon, Ramkumar |
title_short |
Fetal membranes: Potential source of preterm birth biomarkers |
title_full |
Fetal membranes: Potential source of preterm birth biomarkers |
title_fullStr |
Fetal membranes: Potential source of preterm birth biomarkers |
title_full_unstemmed |
Fetal membranes: Potential source of preterm birth biomarkers |
title_sort |
Fetal membranes: Potential source of preterm birth biomarkers |
author |
Menon, Ramkumar |
author_facet |
Menon, Ramkumar Nicolau, Nathalia Noda [UNESP] Bredson, Sarah Polettini, Jossimara |
author_role |
author |
author2 |
Nicolau, Nathalia Noda [UNESP] Bredson, Sarah Polettini, Jossimara |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
The University of Texas Medical Branch at Galveston Universidade Estadual Paulista (UNESP) The University of Texas Medical Branch |
dc.contributor.author.fl_str_mv |
Menon, Ramkumar Nicolau, Nathalia Noda [UNESP] Bredson, Sarah Polettini, Jossimara |
description |
Preterm birth (birth before 37 weeks of complete gestation) is a major pregnancy complication and is the second largest cause of neonatal mortality worldwide. Majority of the preterm births are due to unknown etiologies, and this class of preterm births is known as spontaneous preterm birth (PTB). There are no reliable biomarkers to predict PTB as its causality and pathophysiologic pathways are unclear. Various maternal and fetal intrauterine compartments produce biomarkers that are associated with PTB. However, screening and diagnosis of PTB is difficult due to the overlap between various pathologic events associated with PTB and heterogeneity in biomarker response. Several studies have contributed to our current understanding of the mechanistic role of biomarkers produced by maternal and fetal tissues, but none of them have emerged as diagnostic tools. This chapter reviews knowledge gaps in PTB biomarker literature and discusses some of the fundamental issues associated with biomarker research in PTB. This discussion is based on data generated using human fetal membranes. Fetal membranes (amniochorionic membranes) are fetally derived tissues and forms the innermost lining of the intra-amniotic cavity. They provide structural integrity to the intrauterine cavity and are capable of responding to various maternal-fetal physiologic and pathophysiologic signals. Reports document hundreds of biomarkers produced by fetal membranes that are associated with various pregnancy complications. However, fetal membrane biomarker response is complex, and the diversity in their response makes it difficult to understand the pathways of PTB. This chapter reviews three distinct scenarios where fetal membrane biomarker signature can vary: (1) type of antigen, (2) type of risk exposure, and (3) the race/ethnicity of the subject from which the membranes are derived. This is to highlight the heterogeneity in fetal membrane biomarkers and demonstrate how pathways can be different based on distinct biomarker signature. Understanding both maternal and fetal biomarker response based on an individual's own risk profile is needed to tailor interventions to reduce the risk of PTB. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09-02 2022-04-29T07:28:36Z 2022-04-29T07:28:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bookPart |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-94-007-7696-8_28 General Methods in Biomarker Research and their Applications, v. 1-2, p. 483-529. http://hdl.handle.net/11449/228113 10.1007/978-94-007-7696-8_28 2-s2.0-84958696171 |
url |
http://dx.doi.org/10.1007/978-94-007-7696-8_28 http://hdl.handle.net/11449/228113 |
identifier_str_mv |
General Methods in Biomarker Research and their Applications, v. 1-2, p. 483-529. 10.1007/978-94-007-7696-8_28 2-s2.0-84958696171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
General Methods in Biomarker Research and their Applications |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
483-529 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021368316559360 |