Efeito do ácido zoledrônico sobre o reparo dos tecidos moles sobrejacentes ao sítio de extração dental: estudo envolvendo os principais fatores de risco para o desenvolvimento de osteonecrose dos maxilares

• Autor(a) principal: Cavazana, Thamires Priscila [UNESP]
• Data de Publicação: 2015
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149719; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-31/000868350.pdf
• topic: Osteonecrose; Arcada osseodentária; Tecido conjuntivo; Extração dentária; Difosfonatos; Osteonecrosis

Bisphosphonates (BPs) consists of a drug's range used in the treatment of osteopathy or osteotropic malignancies. The BPs exert potent inhibitory effect on bone resorption. One of its side effects is the occurrence of medication-related osteonecrosis of the jaw (MRONJ). Among the risk factors for the onset of MRONJ (BPs) are: chronic use of nitrogen BPs, especially the zoledronic acid, by intravenous route of administration, feminine gender, advanced age and dental surgical procedures, particularly tooth extractions. The pathogenesis of the disease is poorly understood, making it difficult to prevent and treat. Some in vitro studies point to an effective action of BPs on cells of soft tissues, especially those in overlying of dental extraction sites. The BPs actions on such cells needs further investigation because it could help to elucidate the pathogenesis of MRONJ (BPs) and treatments propositions. The objective of this research project was to evaluate in vivo the effect of chronic treatment with zoledronic acid on the repair process of the overlying soft tissues to dental extraction site in rats that present the major risk factors for the development of MRONJ. Fourteen rats (20 months old) were divided into two groups, SAL and ZOL, which underwent a drug treatment plan for 7 weeks. In the SAL group it was administered intraperitoneally, 0.45 ml of 0.9% sodium chloride solution. In ZOL group it was administered intraperitoneally, 0.45 ml of 0.9% sodium chloride solution plus 100 ug / kg zoledronic acid. The interval between the zoledronate applications, or vehicle was two days. After three weeks of treatment all rats were subjected to extraction of the left mandibular first molar. The animals were sacrificed 28 days after surgery. It was performed histological processing of hemi-mandibles and histological sections...