Sol-gel carrier system: A novel controlled drug delivery

Detalhes bibliográficos
Autor(a) principal: Andreani, Tatiana
Data de Publicação: 2012
Outros Autores: De Souza, Ana Luiza R. [UNESP], Silva, Amélia M., Souto, Eliana B.
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/978-3-642-29265-1_5
http://hdl.handle.net/11449/220512
Resumo: In the recent decades, numerous drug delivery systems based on nanoparticles have been developed. To deliver drugs to a specific site, many vehicles have been designed, including liposomes, lipid and polymeric nanoparticles. However these systems can suffer some limitations such as thermal and physical instability as well as opsonization by reticuloendothelial system. This chapter addresses the development and application of silica gel nanoparticles (nanogels) for drug delivery. The synthesis of nanoparticles by sol-gel technology offers new possibilities and many advantages for embedding organic compounds within silica, controlling their release from the host matrix into a surrounding medium, being a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.
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spelling Sol-gel carrier system: A novel controlled drug deliveryDrug deliveryPatentSilica nanoparticlesSol-gelIn the recent decades, numerous drug delivery systems based on nanoparticles have been developed. To deliver drugs to a specific site, many vehicles have been designed, including liposomes, lipid and polymeric nanoparticles. However these systems can suffer some limitations such as thermal and physical instability as well as opsonization by reticuloendothelial system. This chapter addresses the development and application of silica gel nanoparticles (nanogels) for drug delivery. The synthesis of nanoparticles by sol-gel technology offers new possibilities and many advantages for embedding organic compounds within silica, controlling their release from the host matrix into a surrounding medium, being a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.Department of Pharmaceutical Technology Faculty of Health Sciences UFP, Rua Carlos da Maia, 296Department of Biology and Environment University of Trás-os-Montes e Alto Douro, P.O. Box 1013Centre for Research and Technology of Agro-Environmental and Biological Sciences University of Trás-os-Montes e Alto Douro (CITAB-UTAD)Faculty of Pharmaceutical Sciences UNESPInstitute of Biotechnology and Bioengineering Centre of Genomics and Biotechnology University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD)Faculty of Pharmaceutical Sciences UNESPUFPUniversity of Trás-os-Montes e Alto DouroUniversity of Trás-os-Montes e Alto Douro (CITAB-UTAD)Universidade Estadual Paulista (UNESP)University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD)Andreani, TatianaDe Souza, Ana Luiza R. [UNESP]Silva, Amélia M.Souto, Eliana B.2022-04-28T19:02:11Z2022-04-28T19:02:11Z2012-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart151-166http://dx.doi.org/10.1007/978-3-642-29265-1_5Patenting Nanomedicines: Legal Aspects, Intellectual Property and Grant Opportunities, v. 9783642292651, p. 151-166.http://hdl.handle.net/11449/22051210.1007/978-3-642-29265-1_52-s2.0-84949177735Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPatenting Nanomedicines: Legal Aspects, Intellectual Property and Grant Opportunitiesinfo:eu-repo/semantics/openAccess2022-04-28T19:02:12Zoai:repositorio.unesp.br:11449/220512Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:14:42.697311Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Sol-gel carrier system: A novel controlled drug delivery
title Sol-gel carrier system: A novel controlled drug delivery
spellingShingle Sol-gel carrier system: A novel controlled drug delivery
Andreani, Tatiana
Drug delivery
Patent
Silica nanoparticles
Sol-gel
title_short Sol-gel carrier system: A novel controlled drug delivery
title_full Sol-gel carrier system: A novel controlled drug delivery
title_fullStr Sol-gel carrier system: A novel controlled drug delivery
title_full_unstemmed Sol-gel carrier system: A novel controlled drug delivery
title_sort Sol-gel carrier system: A novel controlled drug delivery
author Andreani, Tatiana
author_facet Andreani, Tatiana
De Souza, Ana Luiza R. [UNESP]
Silva, Amélia M.
Souto, Eliana B.
author_role author
author2 De Souza, Ana Luiza R. [UNESP]
Silva, Amélia M.
Souto, Eliana B.
author2_role author
author
author
dc.contributor.none.fl_str_mv UFP
University of Trás-os-Montes e Alto Douro
University of Trás-os-Montes e Alto Douro (CITAB-UTAD)
Universidade Estadual Paulista (UNESP)
University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD)
dc.contributor.author.fl_str_mv Andreani, Tatiana
De Souza, Ana Luiza R. [UNESP]
Silva, Amélia M.
Souto, Eliana B.
dc.subject.por.fl_str_mv Drug delivery
Patent
Silica nanoparticles
Sol-gel
topic Drug delivery
Patent
Silica nanoparticles
Sol-gel
description In the recent decades, numerous drug delivery systems based on nanoparticles have been developed. To deliver drugs to a specific site, many vehicles have been designed, including liposomes, lipid and polymeric nanoparticles. However these systems can suffer some limitations such as thermal and physical instability as well as opsonization by reticuloendothelial system. This chapter addresses the development and application of silica gel nanoparticles (nanogels) for drug delivery. The synthesis of nanoparticles by sol-gel technology offers new possibilities and many advantages for embedding organic compounds within silica, controlling their release from the host matrix into a surrounding medium, being a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
2022-04-28T19:02:11Z
2022-04-28T19:02:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/978-3-642-29265-1_5
Patenting Nanomedicines: Legal Aspects, Intellectual Property and Grant Opportunities, v. 9783642292651, p. 151-166.
http://hdl.handle.net/11449/220512
10.1007/978-3-642-29265-1_5
2-s2.0-84949177735
url http://dx.doi.org/10.1007/978-3-642-29265-1_5
http://hdl.handle.net/11449/220512
identifier_str_mv Patenting Nanomedicines: Legal Aspects, Intellectual Property and Grant Opportunities, v. 9783642292651, p. 151-166.
10.1007/978-3-642-29265-1_5
2-s2.0-84949177735
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Patenting Nanomedicines: Legal Aspects, Intellectual Property and Grant Opportunities
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 151-166
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129177908412416

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