Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1475-2891-9-46 http://hdl.handle.net/11449/42335 |
Resumo: | Background: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes?Methods: Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive) standard-chow and olive-oil (3.0 g/kg. day); (C-Oleuropein) standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days.Results: After 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO(2)) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO(2), fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C.Conclusions: The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions. |
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Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changesBackground: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes?Methods: Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive) standard-chow and olive-oil (3.0 g/kg. day); (C-Oleuropein) standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days.Results: After 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO(2)) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO(2), fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C.Conclusions: The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São Paulo State Univ, Inst Biol Sci, Dept Chem & Biochem, UNESP, BR-18618000 São Paulo, BrazilSão Paulo State Univ, Sch Med, Postgrad Course Dept Clin & Cardiol, UNESP, BR-18618000 São Paulo, BrazilSão Paulo State Univ, Inst Biol Sci, Dept Chem & Biochem, UNESP, BR-18618000 São Paulo, BrazilSão Paulo State Univ, Sch Med, Postgrad Course Dept Clin & Cardiol, UNESP, BR-18618000 São Paulo, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Ebaid, Geovana Xavier [UNESP]Seiva, Fabio R. F. [UNESP]Rocha, Katiucha K. H. R. [UNESP]Souza, Gisele A. [UNESP]Novelli, Ethel L. B. [UNESP]2014-05-20T15:33:51Z2014-05-20T15:33:51Z2010-10-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1186/1475-2891-9-46Nutrition Journal. London: Biomed Central Ltd., v. 9, p. 9, 2010.1475-2891http://hdl.handle.net/11449/4233510.1186/1475-2891-9-46WOS:000283732300001WOS000283732300001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrition Journal3.5681,447info:eu-repo/semantics/openAccess2024-01-12T06:26:37Zoai:repositorio.unesp.br:11449/42335Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T20:29:04.666077Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
title |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
spellingShingle |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes Ebaid, Geovana Xavier [UNESP] |
title_short |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
title_full |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
title_fullStr |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
title_full_unstemmed |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
title_sort |
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes |
author |
Ebaid, Geovana Xavier [UNESP] |
author_facet |
Ebaid, Geovana Xavier [UNESP] Seiva, Fabio R. F. [UNESP] Rocha, Katiucha K. H. R. [UNESP] Souza, Gisele A. [UNESP] Novelli, Ethel L. B. [UNESP] |
author_role |
author |
author2 |
Seiva, Fabio R. F. [UNESP] Rocha, Katiucha K. H. R. [UNESP] Souza, Gisele A. [UNESP] Novelli, Ethel L. B. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ebaid, Geovana Xavier [UNESP] Seiva, Fabio R. F. [UNESP] Rocha, Katiucha K. H. R. [UNESP] Souza, Gisele A. [UNESP] Novelli, Ethel L. B. [UNESP] |
description |
Background: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes?Methods: Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive) standard-chow and olive-oil (3.0 g/kg. day); (C-Oleuropein) standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days.Results: After 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO(2)) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO(2), fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C.Conclusions: The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-19 2014-05-20T15:33:51Z 2014-05-20T15:33:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1475-2891-9-46 Nutrition Journal. London: Biomed Central Ltd., v. 9, p. 9, 2010. 1475-2891 http://hdl.handle.net/11449/42335 10.1186/1475-2891-9-46 WOS:000283732300001 WOS000283732300001.pdf |
url |
http://dx.doi.org/10.1186/1475-2891-9-46 http://hdl.handle.net/11449/42335 |
identifier_str_mv |
Nutrition Journal. London: Biomed Central Ltd., v. 9, p. 9, 2010. 1475-2891 10.1186/1475-2891-9-46 WOS:000283732300001 WOS000283732300001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrition Journal 3.568 1,447 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045675963777024 |