Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis

Detalhes bibliográficos
Autor(a) principal: Scarminio, Viviane [UNESP]
Data de Publicação: 2012
Outros Autores: Fruet, Andrea C. [UNESP], Witaicenis, Aline [UNESP], Rall, Vera L. M. [UNESP], Di Stasi, Luiz C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.nutres.2012.01.002
http://hdl.handle.net/11449/17554
Resumo: Dietary products are among the therapeutic approaches used to modify intestinal microflora and to promote protective effects during the intestinal inflammatory process. Because the banana plant is rich in resistant starch, which is used by colonic microbiota for the anaerobic production of the short-chain fatty acids that serve as a major fuel source for colonocytes: first, green dwarf banana flour produces protective effects on the intestinal inflammation acting as a prebiotic and, second, combination of this dietary supplementation with prednisolone presents synergistic effects. For this, we used the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. Our results revealed that the protective effect produced by a combination of 10% green dwarf banana flour with prednisolone was more pronounced than those promoted by a single administration of prednisolone or a diet containing 10% or 20% banana flour. This beneficial effect was associated with an improvement in the colonic oxidative status because the banana flour diet prevented the glutathione depletion and inhibited myeloperoxidase activity and lipid peroxidation. In addition, the intestinal anti-inflammatory activity was associated with an inhibition of alkaline phosphatase activity, a reduction in macroscopic and microscopic scores, and an extension of the lesions. In conclusion, the dietary use of the green dwarf banana flour constitutes an important dietary supplement and complementary medicine product to prevention and treatment of human inflammatory bowel disease. (C) 2012 Elsevier B.V. All rights reserved.
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spelling Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitisBananaDietary productsFunctional foodsInflammatory bowel diseaseMusa sp AAAUlcerative colitisTrinitrobenzenesulfonic acid (TNBS)RatDietary products are among the therapeutic approaches used to modify intestinal microflora and to promote protective effects during the intestinal inflammatory process. Because the banana plant is rich in resistant starch, which is used by colonic microbiota for the anaerobic production of the short-chain fatty acids that serve as a major fuel source for colonocytes: first, green dwarf banana flour produces protective effects on the intestinal inflammation acting as a prebiotic and, second, combination of this dietary supplementation with prednisolone presents synergistic effects. For this, we used the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. Our results revealed that the protective effect produced by a combination of 10% green dwarf banana flour with prednisolone was more pronounced than those promoted by a single administration of prednisolone or a diet containing 10% or 20% banana flour. This beneficial effect was associated with an improvement in the colonic oxidative status because the banana flour diet prevented the glutathione depletion and inhibited myeloperoxidase activity and lipid peroxidation. In addition, the intestinal anti-inflammatory activity was associated with an inhibition of alkaline phosphatase activity, a reduction in macroscopic and microscopic scores, and an extension of the lesions. In conclusion, the dietary use of the green dwarf banana flour constitutes an important dietary supplement and complementary medicine product to prevention and treatment of human inflammatory bowel disease. (C) 2012 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, Lab Phytomed, Dept Pharmacol, Inst Biosci,UNESP, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Dept Microbiol & Immunol, Inst Biosci, UNESP, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Lab Phytomed, Dept Pharmacol, Inst Biosci,UNESP, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Dept Microbiol & Immunol, Inst Biosci, UNESP, BR-18618970 Botucatu, SP, BrazilFAPESP: 03/09324-1FAPESP: 07/54516-7Pergamon-Elsevier B.V. LtdUniversidade Estadual Paulista (Unesp)Scarminio, Viviane [UNESP]Fruet, Andrea C. [UNESP]Witaicenis, Aline [UNESP]Rall, Vera L. M. [UNESP]Di Stasi, Luiz C. [UNESP]2014-05-20T13:49:18Z2014-05-20T13:49:18Z2012-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article202-209application/pdfhttp://dx.doi.org/10.1016/j.nutres.2012.01.002Nutrition Research. Oxford: Pergamon-Elsevier B.V. Ltd, v. 32, n. 3, p. 202-209, 2012.0271-5317http://hdl.handle.net/11449/1755410.1016/j.nutres.2012.01.002WOS:000302822100007WOS000302822100007.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrition Research2.7071,135info:eu-repo/semantics/openAccess2024-01-08T06:22:52Zoai:repositorio.unesp.br:11449/17554Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:24:33.859801Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
title Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
spellingShingle Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
Scarminio, Viviane [UNESP]
Banana
Dietary products
Functional foods
Inflammatory bowel disease
Musa sp AAA
Ulcerative colitis
Trinitrobenzenesulfonic acid (TNBS)
Rat
title_short Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
title_full Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
title_fullStr Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
title_full_unstemmed Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
title_sort Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis
author Scarminio, Viviane [UNESP]
author_facet Scarminio, Viviane [UNESP]
Fruet, Andrea C. [UNESP]
Witaicenis, Aline [UNESP]
Rall, Vera L. M. [UNESP]
Di Stasi, Luiz C. [UNESP]
author_role author
author2 Fruet, Andrea C. [UNESP]
Witaicenis, Aline [UNESP]
Rall, Vera L. M. [UNESP]
Di Stasi, Luiz C. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Scarminio, Viviane [UNESP]
Fruet, Andrea C. [UNESP]
Witaicenis, Aline [UNESP]
Rall, Vera L. M. [UNESP]
Di Stasi, Luiz C. [UNESP]
dc.subject.por.fl_str_mv Banana
Dietary products
Functional foods
Inflammatory bowel disease
Musa sp AAA
Ulcerative colitis
Trinitrobenzenesulfonic acid (TNBS)
Rat
topic Banana
Dietary products
Functional foods
Inflammatory bowel disease
Musa sp AAA
Ulcerative colitis
Trinitrobenzenesulfonic acid (TNBS)
Rat
description Dietary products are among the therapeutic approaches used to modify intestinal microflora and to promote protective effects during the intestinal inflammatory process. Because the banana plant is rich in resistant starch, which is used by colonic microbiota for the anaerobic production of the short-chain fatty acids that serve as a major fuel source for colonocytes: first, green dwarf banana flour produces protective effects on the intestinal inflammation acting as a prebiotic and, second, combination of this dietary supplementation with prednisolone presents synergistic effects. For this, we used the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. Our results revealed that the protective effect produced by a combination of 10% green dwarf banana flour with prednisolone was more pronounced than those promoted by a single administration of prednisolone or a diet containing 10% or 20% banana flour. This beneficial effect was associated with an improvement in the colonic oxidative status because the banana flour diet prevented the glutathione depletion and inhibited myeloperoxidase activity and lipid peroxidation. In addition, the intestinal anti-inflammatory activity was associated with an inhibition of alkaline phosphatase activity, a reduction in macroscopic and microscopic scores, and an extension of the lesions. In conclusion, the dietary use of the green dwarf banana flour constitutes an important dietary supplement and complementary medicine product to prevention and treatment of human inflammatory bowel disease. (C) 2012 Elsevier B.V. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
2014-05-20T13:49:18Z
2014-05-20T13:49:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.nutres.2012.01.002
Nutrition Research. Oxford: Pergamon-Elsevier B.V. Ltd, v. 32, n. 3, p. 202-209, 2012.
0271-5317
http://hdl.handle.net/11449/17554
10.1016/j.nutres.2012.01.002
WOS:000302822100007
WOS000302822100007.pdf
url http://dx.doi.org/10.1016/j.nutres.2012.01.002
http://hdl.handle.net/11449/17554
identifier_str_mv Nutrition Research. Oxford: Pergamon-Elsevier B.V. Ltd, v. 32, n. 3, p. 202-209, 2012.
0271-5317
10.1016/j.nutres.2012.01.002
WOS:000302822100007
WOS000302822100007.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nutrition Research
2.707
1,135
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 202-209
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier B.V. Ltd
publisher.none.fl_str_mv Pergamon-Elsevier B.V. Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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