Hypertension and its correlation with renal lesions in dogs with leishmaniosis

• Autor(a) principal: Braga, Eveline Tozzi [UNESP]
• Data de Publicação: 2015
• Outros Autores: Artero de Carvalho Leite, Joao Henrique [UNESP], Rosa, Fernando Azadinho [UNESP], Tivelli, Patricia [UNESP], Araujo, Amanda Mariano [UNESP], Martins de Almeida, Breno Fernando [UNESP], Ferrari, Heitor Flavio [UNESP], Ciarlini, Paulo Cesar [UNESP], Machado, Gisele Fabrino [UNESP], Marcondes, Mary [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612015000100006&lng=en&nrm=iso&tlng=en; http://hdl.handle.net/11449/128463
• topic: Histopathology; Kidney; Leishmania infantum chagasi; Systolic blood pressure; Histopatologia; Rim; Leishmania infantum chagasi; Pressão arterial sistólica

To evaluate the prevalence of hypertension and its correlation with the severity of renal injury and proteinuria in dogs with leishmaniosis, sixty-six dogs were divided into two groups. Group 1 (G1) was composed of 54 dogs included in stage 1 of chronic kidney disease (CKD), and group 2 (G2) of twelve dogs in stages 2 and 3 of CKD. Prevalence of hypertension was 28.8%, comprising 22.2% of the dogs from G1 and 58.3% from G2 (P=0.011). The mean arterial blood pressure (BP) of dogs from G1 (135.7 +/- 20.5) was lower than from G2 (170.0 +/- 26.3) (P <0.001). Urine proteincreatinine ratio (UP/C) revealed values above 0.5 in 75.7% of the dogs, with 34% presenting hypertension. All dogs with hypertension had histopathological and laboratory evidence of glomerular disease. Although there was no statistically significant correlation between elevated BP and the severity of glomerular lesions (P=0.408), there was a statistically significant correlation between elevated BP and increased UP/C in the studied population (P=0.002). Thus, dogs with leishmaniosis and renal disease must be screened for the presence of hypertension so that treatment may be instituted as early as possible, in countries where treatment is allowed, to prevent the progression of renal damage.