Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jerd.12805 http://hdl.handle.net/11449/233243 |
Resumo: | Evaluate the kinetics of hydrogen peroxide (H2O2) degradation, esthetic efficacy and cytotoxicity of a bleaching gel with 35%H2O2 applied on enamel previously covered or not with polymeric nanofibrillar scaffold (SNan), polymeric primer catalyst (PPol), and both. Standardized enamel/dentin discs (n = 128) obtained from bovine teeth were adapted to pulp chambers. After covering enamel with the polymeric products, the bleaching gel was applied for 45 min, establishing the following groups: G1: no treatment (negative control); G2: 35%H2O2 (positive control); G3: SNan; G4: PPol; G5: SNan + PPol; G6: SNan + 35%H2O2; G7: PPol + 35%H2O2; G8: SNan + PPol + 35%H2O2. The kinetics of H2O2 degradation (n = 8), bleaching efficacy (ΔE/ΔWI; n = 8), trans-amelodentinal cytotoxicity (n = 8), and cell morphology (n = 4) were assessed (ANOVA/Tukey test; p < 0.05). Greater H2O2 degradation occurred in G7 and G8. Bleaching efficacy (ΔE) was higher in G6, G7, and G8 in comparison with G2 (p < 0.05). However, no difference was observed for ΔWI (p > 0.05). G8 presented the lower level of trans-amelodentinal diffusion of H2O2, oxidative stress, and toxicity to the MDPC-23 cells (p < 0.05). Polymeric biomaterials increased the kinetics of H2O2 decomposition, as well as maintained the esthetic efficacy and minimized the cytotoxicity caused by a bleaching gel with 35%H2O2. Clinical Significance: Application of a bleaching gel with 35%H2O2 on enamel previously covered by polymeric biomaterials maintains the esthetic efficacy and reduces the cytotoxicity caused by a single session of in-office dental bleaching. |
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Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleachingbleachingcolor sciencedental materialsendo/pulp biologyEvaluate the kinetics of hydrogen peroxide (H2O2) degradation, esthetic efficacy and cytotoxicity of a bleaching gel with 35%H2O2 applied on enamel previously covered or not with polymeric nanofibrillar scaffold (SNan), polymeric primer catalyst (PPol), and both. Standardized enamel/dentin discs (n = 128) obtained from bovine teeth were adapted to pulp chambers. After covering enamel with the polymeric products, the bleaching gel was applied for 45 min, establishing the following groups: G1: no treatment (negative control); G2: 35%H2O2 (positive control); G3: SNan; G4: PPol; G5: SNan + PPol; G6: SNan + 35%H2O2; G7: PPol + 35%H2O2; G8: SNan + PPol + 35%H2O2. The kinetics of H2O2 degradation (n = 8), bleaching efficacy (ΔE/ΔWI; n = 8), trans-amelodentinal cytotoxicity (n = 8), and cell morphology (n = 4) were assessed (ANOVA/Tukey test; p < 0.05). Greater H2O2 degradation occurred in G7 and G8. Bleaching efficacy (ΔE) was higher in G6, G7, and G8 in comparison with G2 (p < 0.05). However, no difference was observed for ΔWI (p > 0.05). G8 presented the lower level of trans-amelodentinal diffusion of H2O2, oxidative stress, and toxicity to the MDPC-23 cells (p < 0.05). Polymeric biomaterials increased the kinetics of H2O2 decomposition, as well as maintained the esthetic efficacy and minimized the cytotoxicity caused by a bleaching gel with 35%H2O2. Clinical Significance: Application of a bleaching gel with 35%H2O2 on enamel previously covered by polymeric biomaterials maintains the esthetic efficacy and reduces the cytotoxicity caused by a single session of in-office dental bleaching.Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)Department of Dentistry Endodontics and Dental Materials School of Dentistry São Paulo University (USP)Department of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP)Department of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)Department of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)Department of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP)Department of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)Department of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Ortecho-Zuta, Uxua [UNESP]de Oliveira Duque, Carla Caroline [UNESP]de Oliveira Ribeiro, Rafael Antonio [UNESP]Leite, Maria Luísa [UNESP]Soares, Diana GabrielaHebling, Josimeri [UNESP]Briso, André Luiz Fraga [UNESP]de Souza Costa, Carlos Alberto [UNESP]2022-05-01T06:02:14Z2022-05-01T06:02:14Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/jerd.12805Journal of Esthetic and Restorative Dentistry.1708-82401496-4155http://hdl.handle.net/11449/23324310.1111/jerd.128052-s2.0-85109402407Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Esthetic and Restorative Dentistryinfo:eu-repo/semantics/openAccess2022-05-01T06:02:14Zoai:repositorio.unesp.br:11449/233243Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T06:02:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
title |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
spellingShingle |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching Ortecho-Zuta, Uxua [UNESP] bleaching color science dental materials endo/pulp biology |
title_short |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
title_full |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
title_fullStr |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
title_full_unstemmed |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
title_sort |
Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching |
author |
Ortecho-Zuta, Uxua [UNESP] |
author_facet |
Ortecho-Zuta, Uxua [UNESP] de Oliveira Duque, Carla Caroline [UNESP] de Oliveira Ribeiro, Rafael Antonio [UNESP] Leite, Maria Luísa [UNESP] Soares, Diana Gabriela Hebling, Josimeri [UNESP] Briso, André Luiz Fraga [UNESP] de Souza Costa, Carlos Alberto [UNESP] |
author_role |
author |
author2 |
de Oliveira Duque, Carla Caroline [UNESP] de Oliveira Ribeiro, Rafael Antonio [UNESP] Leite, Maria Luísa [UNESP] Soares, Diana Gabriela Hebling, Josimeri [UNESP] Briso, André Luiz Fraga [UNESP] de Souza Costa, Carlos Alberto [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ortecho-Zuta, Uxua [UNESP] de Oliveira Duque, Carla Caroline [UNESP] de Oliveira Ribeiro, Rafael Antonio [UNESP] Leite, Maria Luísa [UNESP] Soares, Diana Gabriela Hebling, Josimeri [UNESP] Briso, André Luiz Fraga [UNESP] de Souza Costa, Carlos Alberto [UNESP] |
dc.subject.por.fl_str_mv |
bleaching color science dental materials endo/pulp biology |
topic |
bleaching color science dental materials endo/pulp biology |
description |
Evaluate the kinetics of hydrogen peroxide (H2O2) degradation, esthetic efficacy and cytotoxicity of a bleaching gel with 35%H2O2 applied on enamel previously covered or not with polymeric nanofibrillar scaffold (SNan), polymeric primer catalyst (PPol), and both. Standardized enamel/dentin discs (n = 128) obtained from bovine teeth were adapted to pulp chambers. After covering enamel with the polymeric products, the bleaching gel was applied for 45 min, establishing the following groups: G1: no treatment (negative control); G2: 35%H2O2 (positive control); G3: SNan; G4: PPol; G5: SNan + PPol; G6: SNan + 35%H2O2; G7: PPol + 35%H2O2; G8: SNan + PPol + 35%H2O2. The kinetics of H2O2 degradation (n = 8), bleaching efficacy (ΔE/ΔWI; n = 8), trans-amelodentinal cytotoxicity (n = 8), and cell morphology (n = 4) were assessed (ANOVA/Tukey test; p < 0.05). Greater H2O2 degradation occurred in G7 and G8. Bleaching efficacy (ΔE) was higher in G6, G7, and G8 in comparison with G2 (p < 0.05). However, no difference was observed for ΔWI (p > 0.05). G8 presented the lower level of trans-amelodentinal diffusion of H2O2, oxidative stress, and toxicity to the MDPC-23 cells (p < 0.05). Polymeric biomaterials increased the kinetics of H2O2 decomposition, as well as maintained the esthetic efficacy and minimized the cytotoxicity caused by a bleaching gel with 35%H2O2. Clinical Significance: Application of a bleaching gel with 35%H2O2 on enamel previously covered by polymeric biomaterials maintains the esthetic efficacy and reduces the cytotoxicity caused by a single session of in-office dental bleaching. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T06:02:14Z 2022-05-01T06:02:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jerd.12805 Journal of Esthetic and Restorative Dentistry. 1708-8240 1496-4155 http://hdl.handle.net/11449/233243 10.1111/jerd.12805 2-s2.0-85109402407 |
url |
http://dx.doi.org/10.1111/jerd.12805 http://hdl.handle.net/11449/233243 |
identifier_str_mv |
Journal of Esthetic and Restorative Dentistry. 1708-8240 1496-4155 10.1111/jerd.12805 2-s2.0-85109402407 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Esthetic and Restorative Dentistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046171939176448 |