TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe

Detalhes bibliográficos
Autor(a) principal: Patrone, Luis Gustavo A. [UNESP]
Data de Publicação: 2019
Outros Autores: Duarte, Jaime B. [UNESP], Bícego, Kênia Cardoso [UNESP], Steiner, Alexandre A., Romanovsky, Andrej A., Gargaglioni, Luciane H. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/ph12010019
http://hdl.handle.net/11449/188792
Resumo: Receptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O 2 ) and hypercapnia (7% CO 2 ) by measuring pulmonary ventilation ( ˙V E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2.85 µg/kg, 1 mL/kg]) or intracebroventricular (AMG9810 [2.85 µg/kg, 1 µL] or AMG7905 [28.5 µg/kg, 1 µL]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia.
id UNSP_cf5aecc79c7f0db12fb63e32ffa20e5d
oai_identifier_str oai:repositorio.unesp.br:11449/188792
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breatheBlood pressureChannelsChemosensitivityHypercapniaHypothermiaVentilationReceptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O 2 ) and hypercapnia (7% CO 2 ) by measuring pulmonary ventilation ( ˙V E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2.85 µg/kg, 1 mL/kg]) or intracebroventricular (AMG9810 [2.85 µg/kg, 1 µL] or AMG7905 [28.5 µg/kg, 1 µL]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Animal Morphology and Physiology Faculty of Agricultural and Veterinarian Sciences UNESP at Jaboticabal, Rod. Prof. Paulo Donato Castellane s/nDepartment of Immunology Institute of Biomedical Sciences University of Sao PauloThermoregulation and Systemic Inflammation Laboratory (FeverLab) Trauma Research St. Joseph’s Hospital and Medical CenterDepartment of Animal Morphology and Physiology Faculty of Agricultural and Veterinarian Sciences UNESP at Jaboticabal, Rod. Prof. Paulo Donato Castellane s/nFAPESP: 2015/24785-2FAPESP: 2016/24577-3CAPES: 2017/05318-0FAPESP: 2017/05318-0CNPq: 310293/2015-4Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)St. Joseph’s Hospital and Medical CenterPatrone, Luis Gustavo A. [UNESP]Duarte, Jaime B. [UNESP]Bícego, Kênia Cardoso [UNESP]Steiner, Alexandre A.Romanovsky, Andrej A.Gargaglioni, Luciane H. [UNESP]2019-10-06T16:19:23Z2019-10-06T16:19:23Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ph12010019Pharmaceuticals, v. 12, n. 1, 2019.1424-8247http://hdl.handle.net/11449/18879210.3390/ph120100192-s2.0-85062338083Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticalsinfo:eu-repo/semantics/openAccess2024-06-06T18:41:31Zoai:repositorio.unesp.br:11449/188792Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:13:25.695153Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
title TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
spellingShingle TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
Patrone, Luis Gustavo A. [UNESP]
Blood pressure
Channels
Chemosensitivity
Hypercapnia
Hypothermia
Ventilation
title_short TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
title_full TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
title_fullStr TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
title_full_unstemmed TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
title_sort TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe
author Patrone, Luis Gustavo A. [UNESP]
author_facet Patrone, Luis Gustavo A. [UNESP]
Duarte, Jaime B. [UNESP]
Bícego, Kênia Cardoso [UNESP]
Steiner, Alexandre A.
Romanovsky, Andrej A.
Gargaglioni, Luciane H. [UNESP]
author_role author
author2 Duarte, Jaime B. [UNESP]
Bícego, Kênia Cardoso [UNESP]
Steiner, Alexandre A.
Romanovsky, Andrej A.
Gargaglioni, Luciane H. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
St. Joseph’s Hospital and Medical Center
dc.contributor.author.fl_str_mv Patrone, Luis Gustavo A. [UNESP]
Duarte, Jaime B. [UNESP]
Bícego, Kênia Cardoso [UNESP]
Steiner, Alexandre A.
Romanovsky, Andrej A.
Gargaglioni, Luciane H. [UNESP]
dc.subject.por.fl_str_mv Blood pressure
Channels
Chemosensitivity
Hypercapnia
Hypothermia
Ventilation
topic Blood pressure
Channels
Chemosensitivity
Hypercapnia
Hypothermia
Ventilation
description Receptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O 2 ) and hypercapnia (7% CO 2 ) by measuring pulmonary ventilation ( ˙V E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2.85 µg/kg, 1 mL/kg]) or intracebroventricular (AMG9810 [2.85 µg/kg, 1 µL] or AMG7905 [28.5 µg/kg, 1 µL]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:19:23Z
2019-10-06T16:19:23Z
2019-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/ph12010019
Pharmaceuticals, v. 12, n. 1, 2019.
1424-8247
http://hdl.handle.net/11449/188792
10.3390/ph12010019
2-s2.0-85062338083
url http://dx.doi.org/10.3390/ph12010019
http://hdl.handle.net/11449/188792
identifier_str_mv Pharmaceuticals, v. 12, n. 1, 2019.
1424-8247
10.3390/ph12010019
2-s2.0-85062338083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceuticals
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128619711561728