Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.resp.2016.10.011 http://hdl.handle.net/11449/162399 |
Resumo: | The Locus coeruleus (LC) is a pontine area that contributes to the CO2/pH chemosensitivity. LC cells express erythropoietin (Epo) receptors (EpoR), and Epo in the brainstem is a potent normoxic and hypoxic respiratory stimulant. However, a recent study showed that the intra-cisternal injection (ICI) of Epo antagonist does not alter the hypercapnic ventilatory response in mice. As ICI leads to a widespread dispersal of the product throughout the brainstem, in this work we evaluated the specific impact of Epo in the LC-mediated ventilatory response to CO2 (by whole body plethysmography) in juvenile male Wistar rats. Normocapnic and hypercapnic ventilation were evaluated before and after unilateral microinjection of Epo (1 ng/100 nL) into the LC. To evaluate the long-term effect of Epo, the HcVR was re-evaluated 24h later. Our results show that Epo attenuates the hypercapnic ventilation. We conclude that Epo in the LC tunes the hypercapnia-induced hyperpnea. (C) 2016 Elsevier B.V. All rights reserved. |
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Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in ratsErythropoietinLocus coeruleusCentral chemosensitivityHypercapniaVentilationThe Locus coeruleus (LC) is a pontine area that contributes to the CO2/pH chemosensitivity. LC cells express erythropoietin (Epo) receptors (EpoR), and Epo in the brainstem is a potent normoxic and hypoxic respiratory stimulant. However, a recent study showed that the intra-cisternal injection (ICI) of Epo antagonist does not alter the hypercapnic ventilatory response in mice. As ICI leads to a widespread dispersal of the product throughout the brainstem, in this work we evaluated the specific impact of Epo in the LC-mediated ventilatory response to CO2 (by whole body plethysmography) in juvenile male Wistar rats. Normocapnic and hypercapnic ventilation were evaluated before and after unilateral microinjection of Epo (1 ng/100 nL) into the LC. To evaluate the long-term effect of Epo, the HcVR was re-evaluated 24h later. Our results show that Epo attenuates the hypercapnic ventilation. We conclude that Epo in the LC tunes the hypercapnia-induced hyperpnea. (C) 2016 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Canadian Institutes of health ResearchFonds de recherche du Quebec-Sante (FRQ-S)Sao Paulo State Univ FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, BrazilUniv Laval, Ctr Rech, CHU Quebec, Dept Pediat,Fac Med, Pavillon St Francois Assise, Quebec City, PQ, CanadaSao Paulo State Univ FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, BrazilFAPESP: FAPESP - 2012/19966-0CNPq: CNPq - 442560/2014-1Elsevier B.V.Universidade Estadual Paulista (Unesp)Univ LavalSilva, Carlos A. [UNESP]Vicente, Mariane C. [UNESP]Tenorio-Lopes, LuanaSoliz, JorgeGargaglioni, Luciane H. [UNESP]2018-11-26T17:16:32Z2018-11-26T17:16:32Z2017-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11-18application/pdfhttp://dx.doi.org/10.1016/j.resp.2016.10.011Respiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 236, p. 11-18, 2017.1569-9048http://hdl.handle.net/11449/16239910.1016/j.resp.2016.10.011WOS:000392771800003WOS000392771800003.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRespiratory Physiology & Neurobiology0,682info:eu-repo/semantics/openAccess2024-06-06T18:42:26Zoai:repositorio.unesp.br:11449/162399Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:21:05.385236Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
title |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
spellingShingle |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats Silva, Carlos A. [UNESP] Erythropoietin Locus coeruleus Central chemosensitivity Hypercapnia Ventilation |
title_short |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
title_full |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
title_fullStr |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
title_full_unstemmed |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
title_sort |
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats |
author |
Silva, Carlos A. [UNESP] |
author_facet |
Silva, Carlos A. [UNESP] Vicente, Mariane C. [UNESP] Tenorio-Lopes, Luana Soliz, Jorge Gargaglioni, Luciane H. [UNESP] |
author_role |
author |
author2 |
Vicente, Mariane C. [UNESP] Tenorio-Lopes, Luana Soliz, Jorge Gargaglioni, Luciane H. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Laval |
dc.contributor.author.fl_str_mv |
Silva, Carlos A. [UNESP] Vicente, Mariane C. [UNESP] Tenorio-Lopes, Luana Soliz, Jorge Gargaglioni, Luciane H. [UNESP] |
dc.subject.por.fl_str_mv |
Erythropoietin Locus coeruleus Central chemosensitivity Hypercapnia Ventilation |
topic |
Erythropoietin Locus coeruleus Central chemosensitivity Hypercapnia Ventilation |
description |
The Locus coeruleus (LC) is a pontine area that contributes to the CO2/pH chemosensitivity. LC cells express erythropoietin (Epo) receptors (EpoR), and Epo in the brainstem is a potent normoxic and hypoxic respiratory stimulant. However, a recent study showed that the intra-cisternal injection (ICI) of Epo antagonist does not alter the hypercapnic ventilatory response in mice. As ICI leads to a widespread dispersal of the product throughout the brainstem, in this work we evaluated the specific impact of Epo in the LC-mediated ventilatory response to CO2 (by whole body plethysmography) in juvenile male Wistar rats. Normocapnic and hypercapnic ventilation were evaluated before and after unilateral microinjection of Epo (1 ng/100 nL) into the LC. To evaluate the long-term effect of Epo, the HcVR was re-evaluated 24h later. Our results show that Epo attenuates the hypercapnic ventilation. We conclude that Epo in the LC tunes the hypercapnia-induced hyperpnea. (C) 2016 Elsevier B.V. All rights reserved. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-01 2018-11-26T17:16:32Z 2018-11-26T17:16:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.resp.2016.10.011 Respiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 236, p. 11-18, 2017. 1569-9048 http://hdl.handle.net/11449/162399 10.1016/j.resp.2016.10.011 WOS:000392771800003 WOS000392771800003.pdf |
url |
http://dx.doi.org/10.1016/j.resp.2016.10.011 http://hdl.handle.net/11449/162399 |
identifier_str_mv |
Respiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 236, p. 11-18, 2017. 1569-9048 10.1016/j.resp.2016.10.011 WOS:000392771800003 WOS000392771800003.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Respiratory Physiology & Neurobiology 0,682 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11-18 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129419038949376 |